New approaches to Leishmania chemotherapy: pteridine reductase 1 (PTRI) as, 1997. ,
PTRI: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major, PNAS USA, issue.24, pp.91-11442, 1994. ,
Multiple drug resistance and conservative amplification of the H region in Leishmania major, J Biol Chem, vol.264, issue.25, pp.15094-15103, 1989. ,
A novel antifolate resistance gene on the amplified H circle of Leishmania, EMBO J, vol.11, pp.910-3601, 1992. ,
Isolation and characterization of a mutant dihydrofolate reductase?thymidylate synthase from methotrexate? resistant Leishmania cells, J Biol Chem, issue.14, pp.269-10590, 1994. ,
Biopterin conversion to reduced folates byLeishmania donovani promastigotes, Molecular and Biochemical Parasitology, vol.49, issue.1, pp.21-28, 1991. ,
DOI : 10.1016/0166-6851(91)90126-Q
Crystallization of recombinant Leishmania major pterdine reductase 1 (PTRI), Acta Cryst D Biol Crystallogr, pp.55-1608, 1999. ,
Leishmania major pteridine reductase 1 belongs to the short chain dehydrogenase family: Stereochemical and kinetic evidence, Biochemistry, issue.12, pp.37-4093, 1998. ,
The roles of pteridine reductese 1 (PTRI) and dihydrofolate reductase ? thymidylate synthase (DHFR-TS) in pteridine metabolism in the protozoan parasite Leishmania major, J Biol Chem, issue.21, pp.272-13883, 1997. ,
Drug resistance in leishmaniasis: its implication in systemic chemotherapy of cutaneous and mucocutaneous disease, Am J Trop Med Hyg, vol.47, issue.1, pp.117-126, 1992. ,
Pteridine salvage throughout the Leishmania infectious cycle: implications for antifolate chemotherapy, Molecular and Biochemical Parasitology, vol.113, issue.2, pp.199-213, 2001. ,
DOI : 10.1016/S0166-6851(01)00213-4
Biosynthesis and Metabolism of Tetrahydrobiopterin and Molybdopterin, Annual Review of Biochemistry, vol.54, issue.1, 1985. ,
DOI : 10.1146/annurev.bi.54.070185.003501
Molecular Cloning and Expression of Iranian Leishmania major Pteridine Reductase 1, Iranian J Parasitol, vol.3, issue.2, pp.1-9, 2008. ,
Protein expression, a practical approach, pp.169-200, 1999. ,
Molecular cloning . A laboratory manual, pp.4-14, 2001. ,
Overexpression in Escherichia coli and purification of pteridine reductase (PTR1) from a clinical isolate of Leishmania donovani, Protein Expression and Purification, vol.38, issue.2, pp.228-264, 2004. ,
DOI : 10.1016/j.pep.2004.08.015
Characterization of Leishmania infection in rodents from endemic areas of the Islamic Republic of Iran, East Mediterr Health J, vol.10, pp.4-5, 2004. ,
Application of direct agglutination test (DAT) for the diagnosis and seroepidemiological studies of visceral leishmaniasis in the Islamic Republic of Iran, Iranian J Parasitol, vol.1, issue.1, pp.15-25, 2006. ,
Biochemical and molecular mechanisms of drug resistance in parasites, Tropical Medicine and International Health, vol.244, issue.11, pp.874-876, 2001. ,
DOI : 10.1016/S0166-6851(97)00215-6
Drug resistance in Indian visceral leishmaniasis, Tropical Medicine and International Health, vol.793, issue.11, pp.849-855, 2001. ,
DOI : 10.1086/318122
Glucantime-resistant Leishmania tropica isolated from Iranian patients with cutaneous leishmaniasis are sensitive to alternative antileishmania drugs, Parasitology Research, vol.194, issue.5, pp.1319-1322, 2007. ,
DOI : 10.1007/s00436-007-0638-0
A randomized, placebo, controlled trial of a two-week regimen of aminacidine (paromomycin) ointment for treatment of cutaneous leishmaniasis in Iran, Am J Trop Med Hyg, issue.6, pp.53-648, 1995. ,
Treatment of cutaneous leishmaniasis with aminosidine (paromomaycin) ointement: double ? blind, randomized trial in the lslamic Republic of Iran, Bulletin WHO, issue.5, pp.81-353, 2003. ,
Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica., Proceedings of the National Academy of Sciences, vol.80, issue.8, pp.2132-2136, 1983. ,
DOI : 10.1073/pnas.80.8.2132
PTRI: A reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major, Proc Natl Acad Sci, issue.24, pp.91-11442, 1994. ,
The roles of pteridine reductese 1 and dihydrofolate reductase?thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major, J Biol Chem, issue.21, pp.272-13883, 1997. ,
Pteridine salvage throughout the Leishmania infectious cycle: implications for antifolate chemotherapy, Molecular and Biochemical Parasitology, vol.113, issue.2, pp.199-213, 2001. ,
DOI : 10.1016/S0166-6851(01)00213-4
Gene inhibition using antisense oligodeoxynucleotides, Nature, vol.372, issue.6504, pp.33-335, 2002. ,
DOI : 10.1038/372333a0
Role of Leishmania (Leishmania) chagasi amastigote cysteine protease in intracellular parasite survival: studies by gene disruption and antisense mRNA inhibition, BMC Molecular Biology, vol.6, issue.1, p.3, 2005. ,
DOI : 10.1186/1471-2199-6-3
An antisense plasmid targeting surviving expression induces apoptosis and sensitizes hepatocarcinoma cells to chemotherapy, J Huazhong Univ Sci Technology Med Sci, vol.23, issue.4, pp.387-391, 2003. ,
A Novel Class of Developmentally Regulated Noncoding RNAs in Leishmania, Eukaryotic Cell, vol.5, issue.12, pp.2033-2046, 2006. ,
DOI : 10.1128/EC.00147-06