R. F. Anders, P. E. Crewther, S. Edwards, M. Margetts, M. L. Matthew et al., Immunisation with recombinant AMA-1 protects mice against infection with Plasmodium chabaudi, Vaccine, vol.16, issue.2-3, pp.240-247, 1998.
DOI : 10.1016/S0264-410X(97)88331-4

N. M. Anstey, B. Russell, T. W. Yeo, and R. N. Price, The pathophysiology of vivax malaria, Trends in Parasitology, vol.25, issue.5, pp.220-227, 2009.
DOI : 10.1016/j.pt.2009.02.003

M. Arévalo-herrera, C. Chitnis, and S. Herrera, vaccine, Human Vaccines, vol.6, issue.1, pp.124-132, 2010.
DOI : 10.4161/hv.6.1.9931

S. Zakeri, Population genetic structure and polymorphism analysis of gene encoding apical membrane antigen-1 (AMA-1) of Iranian Plasmodium vivax wild isolates, Acta Tropica, vol.126, issue.3, pp.269-279, 2013.
DOI : 10.1016/j.actatropica.2013.02.017
URL : https://hal.archives-ouvertes.fr/pasteur-00826155

A. E. Arias and A. Corredor, Low response of Colombian strains of Plasmodium vivax to classical antimalarial therapy, Trop. Med. Parasitol, vol.40, pp.21-23, 1989.

J. K. Baird, Chloroquine Resistance in Plasmodium vivax, Antimicrobial Agents and Chemotherapy, vol.48, issue.11, pp.4075-4083, 2004.
DOI : 10.1128/AAC.48.11.4075-4083.2004

F. Balloux and N. Lugon-moulin, The estimation of population differentiation with microsatellite markers, Molecular Ecology, vol.16, issue.2, pp.155-165, 2002.
DOI : 10.1038/74238

L. H. Bannister, J. M. Hopkins, A. R. Dluzewski, G. Margos, I. T. Williams et al., Plasmodium falciparum apical membrane antigen 1 (PfAMA-1) is translocated within micronemes along subpellicular microtubules during merozoite development, Journal of Cell Science, vol.116, issue.18, pp.3825-3834, 2003.
DOI : 10.1242/jcs.00665

L. L. Bueno, F. P. Lobo, C. G. Morais, L. C. Mourão, R. A. De-Ávila et al., Identification of a Highly Antigenic Linear B Cell Epitope within Plasmodium vivax Apical Membrane Antigen 1 (AMA-1), PLoS ONE, vol.28, issue.6, 2011.
DOI : 10.1371/journal.pone.0021289.s001

Q. Cheng and A. Saul, Sequence analysis of the apical membrane antigen I (AMA-1) of plasmodium vivax, Molecular and Biochemical Parasitology, vol.65, issue.1, pp.183-187, 1994.
DOI : 10.1016/0166-6851(94)90127-9

M. L. Chesne-seck, J. C. Pizarro, B. Vulliez-le-normand, C. R. Collins, M. J. Blackman et al., Structural comparison of apical membrane antigen 1 orthologues and paralogues in apicomplexan parasites, Molecular and Biochemical Parasitology, vol.144, issue.1, pp.55-67, 2005.
DOI : 10.1016/j.molbiopara.2005.07.007

J. Y. Chung, E. H. Chun, J. H. Chun, and W. G. Kho, Analysis of the Plasmodium vivax apical membrane antigen-1 gene from re-emerging Korean isolates, Parasitology Research, vol.90, issue.4, pp.325-329, 2003.
DOI : 10.1007/s00436-002-0777-2

A. Cortés, M. Mellombo, I. Mueller, A. Benet, J. C. Reeder et al., Geographical Structure of Diversity and Differences between Symptomatic and Asymptomatic Infections for Plasmodium falciparum Vaccine Candidate AMA1, Infection and Immunity, vol.71, issue.3, pp.1416-1426, 2003.
DOI : 10.1128/IAI.71.3.1416-1426.2003

P. D. Crompton, S. K. Pierce, and L. H. Miller, Advances and challenges in malaria vaccine development, Journal of Clinical Investigation, vol.120, issue.12, pp.4168-4178, 2010.
DOI : 10.1172/JCI44423

L. Cui, A. A. Escalante, M. Imwong, and G. Snounou, The genetic diversity of Plasmodium vivax populations, Trends in Parasitology, vol.19, issue.5, pp.220-226, 2003.
DOI : 10.1016/S1471-4922(03)00085-0

W. C. De-souza-neiras, L. M. De-melo, and R. L. Machado, The genetic diversity of Plasmodium vivax: a review, Mem??rias do Instituto Oswaldo Cruz, vol.102, issue.3, pp.245-254, 2007.
DOI : 10.1590/S0074-02762007000300002

J. A. Deans, T. Alderson, A. W. Thomas, G. H. Mitchell, E. S. Lennox et al., Rat monoclonal antibodies which inhibit the in vitro multiplication of Plasmodium knowlesi, Clin. Exp. Immunol, vol.49, pp.297-309, 1982.

S. Dias, M. Somarathna, A. Manamperi, A. A. Escalante, A. M. Gunasekera et al., Evaluation of the genetic diversity of domain II of Plasmodium vivax Apical Membrane Antigen 1 (PvAMA-1) and the ensuing strain-specific immune responses in patients from Sri Lanka, Vaccine, vol.29, issue.43, pp.7491-7504, 2011.
DOI : 10.1016/j.vaccine.2011.07.029

S. Dutta, P. Malhotra, and V. S. Chauhan, Sequence analysis of apical membrane antigen 1 (AMA-1) of Plasmodium cynomolgi bastianelli, Molecular and Biochemical Parasitology, vol.73, issue.1-2, pp.267-270, 1995.
DOI : 10.1016/0166-6851(95)00112-E

S. Dutta, J. D. Haynes, J. K. Moch, A. Barbosa, and D. E. Lanar, Invasion-inhibitory antibodies inhibit proteolytic processing of apical membrane antigen 1 of Plasmodium falciparum merozoites, Proceedings of the National Academy of Sciences, vol.100, issue.21, pp.12295-12300, 2003.
DOI : 10.1073/pnas.2032858100

R. Egea, S. Casillas, and A. Barbadilla, Standard and generalized McDonald-Kreitman test: a website to detect selection by comparing different classes of DNA sites, Nucleic Acids Research, vol.36, issue.Web Server, pp.157-162, 2008.
DOI : 10.1093/nar/gkn337

M. Figtree, C. J. Pasay, R. Slade, Q. Cheng, N. Cloonan et al., Plasmodium vivax synonymous substitution frequencies, evolution and population structure deduced from diversity in AMA 1 and MSP 1 genes, Molecular and Biochemical Parasitology, vol.108, issue.1, pp.53-66, 2000.
DOI : 10.1016/S0166-6851(00)00204-8

Y. X. Fu and W. H. Li, Statistical tests of neutrality of mutations, Genetics, vol.133, pp.693-709, 1993.

M. R. Galinski and J. W. Barnwell, Plasmodium vivax: Merozoites, invasion of reticulocytes and considerations for malaria vaccine development, Parasitology Today, vol.12, issue.1, pp.20-29, 1996.
DOI : 10.1016/0169-4758(96)80641-7

S. Garg, M. T. Alam, M. K. Das, V. Dev, A. Kumar et al., Sequence diversity and natural selection at domain I of the apical membrane antigen 1 among Indian Plasmodium falciparum populations, Malaria Journal, vol.6, issue.1, p.154, 2007.
DOI : 10.1186/1475-2875-6-154

P. Grynberg, C. J. Fontes, A. L. Hughes, and E. M. Braga, Polymorphism at the apical membrane antigen 1 locus reflects the world population history of Plasmodium vivax, BMC Evolutionary Biology, vol.8, issue.1, p.123, 2008.
DOI : 10.1186/1471-2148-8-123

C. A. Guerra, R. W. Snow, and S. I. Hay, Mapping the global extent of malaria in 2005, Trends in Parasitology, vol.22, issue.8, pp.353-358, 2005.
DOI : 10.1016/j.pt.2006.06.006

A. M. Gunasekera, T. Wickramarachchi, D. E. Neafsey, I. Ganguli, L. Perera et al., Genetic Diversity and Selection at the Plasmodium vivax Apical Membrane Antigen-1 (PvAMA-1) Locus in a Sri Lankan Population, Molecular Biology and Evolution, vol.24, issue.4, pp.939-947, 2007.
DOI : 10.1093/molbev/msm013

E. T. Han, J. H. Park, E. H. Shin, M. H. Choi, M. D. Oh et al., Apical membrane antigen-1 (AMA-1) gene sequences of re-emerging Plasmodium vivax in South Korea, The Korean Journal of Parasitology, vol.40, issue.3, pp.157-162, 2002.
DOI : 10.3347/kjp.2002.40.3.157

S. I. Hay, C. A. Guerra, A. J. Tatem, A. M. Noor, and R. W. Snow, The global distribution and population at risk of malaria: past, present, and future, The Lancet Infectious Diseases, vol.4, issue.6, pp.327-336, 2004.
DOI : 10.1016/S1473-3099(04)01043-6

A. B. Hehl, C. Lekutis, M. E. Grigg, P. J. Bradley, J. F. Dubremetz et al., Toxoplasma gondii Homologue of Plasmodium Apical Membrane Antigen 1 Is Involved in Invasion of Host Cells, Infection and Immunity, vol.68, issue.12, pp.7078-7086, 2000.
DOI : 10.1128/IAI.68.12.7078-7086.2000

A. N. Hodder, P. E. Crewther, M. L. Matthew, G. E. Reid, R. L. Moritz et al., The disulfide bond structure of Plasmodium apical membrane antigen-1, J. Biol. Chem, vol.271, pp.29446-29452, 1996.

A. A. Holder, Preventing merozoite invasion of erythrocytes Malaria Vaccine Development: A Multi-Immune Approach, pp.77-104, 1994.

S. A. Howell, C. Withers-martinez, C. H. Kocken, A. W. Thomas, and M. J. Blackman, Proteolytic Processing and Primary Structure of Plasmodium falciparum Apical Membrane Antigen-1, Journal of Biological Chemistry, vol.276, issue.33, pp.31311-31320, 2001.
DOI : 10.1074/jbc.M103076200

S. A. Howell, I. Well, S. L. Fleck, C. Kettleborough, C. R. Collins et al., A Single Malaria Merozoite Serine Protease Mediates Shedding of Multiple Surface Proteins by Juxtamembrane Cleavage, Journal of Biological Chemistry, vol.278, issue.26, pp.23890-23898, 2003.
DOI : 10.1074/jbc.M302160200

C. H. Kocken, C. Withers-martinez, M. A. Dubbeld, A. Van-der-wel, F. Hackett et al., High-Level Expression of the Malaria Blood-Stage Vaccine Candidate Plasmodium falciparum Apical Membrane Antigen 1 and Induction of Antibodies That Inhibit Erythrocyte Invasion, Infection and Immunity, vol.70, issue.8, pp.4471-4476, 2002.
DOI : 10.1128/IAI.70.8.4471-4476.2002

F. Li, A. Dluzewski, A. M. Coley, A. Thomas, L. Tilley et al., Phage-displayed Peptides Bind to the Malarial Protein Apical Membrane Antigen-1 and Inhibit the Merozoite Invasion of Host Erythrocytes, Journal of Biological Chemistry, vol.277, issue.52, pp.50303-50310, 2002.
DOI : 10.1074/jbc.M207985200

P. Librado and J. Rozas, DnaSP v5: a software for comprehensive analysis of DNA polymorphism data, Bioinformatics, vol.25, issue.11, pp.1451-1452, 2009.
DOI : 10.1093/bioinformatics/btp187

C. List, W. Qi, E. Maag, B. Gottstein, N. Müller et al., Serodiagnosis of Echinococcus spp. Infection: Explorative Selection of Diagnostic Antigens by Peptide Microarray, PLoS Neglected Tropical Diseases, vol.131, issue.8, p.771, 2010.
DOI : 10.1371/journal.pntd.0000771.s003

V. M. Marshall, M. G. Peterson, A. M. Lew, and D. J. Kemp, Structure of the apical membrane antigen I (AMA-1) of Plasmodium chabaudi, Molecular and Biochemical Parasitology, vol.37, issue.2, pp.281-283, 1989.
DOI : 10.1016/0166-6851(89)90160-6

J. H. Mcdonald and M. Kreitman, Adaptive protein evolution at the Adh locus in Drosophila, Nature, vol.351, issue.6328, pp.652-654, 1991.
DOI : 10.1038/351652a0

K. Mendis, B. J. Sina, P. Marchesini, and R. Carter, The neglected burden of Plasmodium vivax malaria, Am. J. Trop. Med. Hyg, vol.64, pp.97-106, 2001.

G. H. Mitchell, A. W. Thomas, G. Margos, A. R. Dluzewski, and L. H. Bannister, Apical Membrane Antigen 1, a Major Malaria Vaccine Candidate, Mediates the Close Attachment of Invasive Merozoites to Host Red Blood Cells, Infection and Immunity, vol.72, issue.1, pp.154-158, 2004.
DOI : 10.1128/IAI.72.1.154-158.2004

S. U. Moon, B. K. Na, J. M. Kang, J. Y. Kim, S. H. Cho et al., Genetic polymorphism and effect of natural selection at domain I of apical membrane antigen-1 (AMA-1) in Plasmodium vivax isolates from Myanmar, Acta Tropica, vol.114, issue.2, pp.71-75, 2010.
DOI : 10.1016/j.actatropica.2010.01.006

B. C. Múfalo, F. Gentil, D. Y. Bargieri, F. T. Costa, M. M. Rodrigues et al., Plasmodium vivax apical membrane antigen-1: comparative recognition of different domains by antibodies induced during natural human infection, Microbes and Infection, vol.10, issue.12-13, pp.1266-1273, 2008.
DOI : 10.1016/j.micinf.2008.07.023

D. L. Narum and A. W. Thomas, Differential localization of full-length and processed forms of PF83/AMA-1 an apical membrane antigen of Plasmodium falciparum merozoites, Molecular and Biochemical Parasitology, vol.67, issue.1, pp.59-68, 1994.
DOI : 10.1016/0166-6851(94)90096-5

R. L. Ord, A. Tami, and C. J. Sutherland, ama1 Genes of Sympatric Plasmodium vivax and P. falciparum from Venezuela Differ Significantly in Genetic Diversity and Recombination Frequency, PLoS ONE, vol.286, issue.10, 2008.
DOI : 10.1371/journal.pone.0003366.t005

M. G. Peterson, V. M. Marshall, J. A. Smythe, P. E. Crewther, A. Lew et al., Integral membrane protein located in the apical complex of Plasmodium falciparum., Molecular and Cellular Biology, vol.9, issue.7, pp.3151-3154, 1989.
DOI : 10.1128/MCB.9.7.3151

J. C. Pizarro, B. Vulliez-le-normand, M. L. Chesne-seck, C. R. Collins, C. Withers-martinez et al., Crystal Structure of the Malaria Vaccine Candidate Apical Membrane Antigen 1, Crystal structure of the malaria vaccine candidate apical membrane antigen 1, pp.408-411, 2005.
DOI : 10.1126/science.1107449

S. D. Polley, T. Mwangi, C. H. Kocken, A. W. Thomas, S. Dutta et al., Human antibodies to recombinant protein constructs of Plasmodium falciparum Apical Membrane Antigen 1 (AMA1) and their associations with protection from malaria, Vaccine, vol.23, issue.5, pp.718-728, 2004.
DOI : 10.1016/j.vaccine.2004.05.031

R. N. Price, E. Tjitra, C. A. Guerra, S. Yeung, N. J. White et al., Vivax malaria: neglected and not benign, Am. J. Trop. Med. Hyg, vol.77, pp.79-87, 2007.

R. N. Price, N. M. Douglas, and N. M. Anstey, New developments in Plasmodium vivax malaria: severe disease and the rise of chloroquine resistance, Current Opinion in Infectious Diseases, vol.22, issue.5, pp.430-435, 2009.
DOI : 10.1097/QCO.0b013e32832f14c1

C. Putaporntip, S. Jongwutiwes, P. Grynberg, L. Cui, and A. L. Hughes, Nucleotide sequence polymorphism at the apical membrane antigen-1 locus reveals population history of Plasmodium vivax in Thailand, Infection, Genetics and Evolution, vol.9, issue.6, pp.1295-1300, 2009.
DOI : 10.1016/j.meegid.2009.07.005

V. Rajesh, M. Elamaran, S. Vidya, M. Gowrishankar, D. Kochar et al., Plasmodium vivax: Genetic diversity of the apical membrane antigen-1 (AMA-1) in isolates from India, Experimental Parasitology, vol.116, issue.3, pp.252-256, 2007.
DOI : 10.1016/j.exppara.2007.01.006

E. J. Remarque, B. W. Faber, C. H. Kocken, and A. W. Thomas, Apical membrane antigen 1: a malaria vaccine candidate in review, Trends in Parasitology, vol.24, issue.2, pp.74-84, 2008.
DOI : 10.1016/j.pt.2007.12.002

T. L. Richie and A. Saul, Progress and challenges for malaria vaccines, Nature, vol.415, issue.6872, pp.694-701, 2002.
DOI : 10.1038/415694a

E. M. Riley, G. E. Wagner, M. F. Ofori, J. G. Wheeler, B. D. Akanmori et al., Lack of Association between Maternal Antibody and Protection of African Infants from Malaria Infection, Infection and Immunity, vol.68, issue.10, pp.5856-5863, 2000.
DOI : 10.1128/IAI.68.10.5856-5863.2000

M. H. Rodrigues, K. M. Rodrigues, T. R. Oliveira, A. N. Comodo, M. M. Rodrigues et al., Antibody response of naturally infected individuals to recombinant Plasmodium vivax apical membrane antigen-1, International Journal for Parasitology, vol.35, issue.2, pp.185-192, 2005.
DOI : 10.1016/j.ijpara.2004.11.003

S. J. Rogerson and R. Carter, Severe Vivax Malaria: Newly Recognised or Rediscovered?, PLoS Medicine, vol.37, issue.6, p.136, 2008.
DOI : 0020-7519(2007)037[1551:POECIV]2.0.CO;2
URL : http://doi.org/10.1371/journal.pmed.0050136

J. Rozas, J. C. Sanchezdelbarrio, X. Messeguer, and R. Rozas, DnaSP, DNA polymorphism analyses by the coalescent and other methods, Bioinformatics, vol.19, issue.18, pp.2496-2497, 2003.
DOI : 10.1093/bioinformatics/btg359

S. Saha and G. P. Raghava, Prediction of continuous B-cell epitopes in an antigen using recurrent neural network, Proteins: Structure, Function, and Bioinformatics, vol.326, issue.1, pp.40-48, 2006.
DOI : 10.1002/prot.21078

S. Sharma and S. Pathak, Malaria vaccine: a current perspective, J. Vector. Borne. Dis, vol.45, pp.1-20, 2008.

O. Silvie, J. F. Franetich, S. Charrin, M. S. Mueller, A. Siau et al., A Role for Apical Membrane Antigen 1 during Invasion of Hepatocytes by Plasmodium falciparum Sporozoites, Journal of Biological Chemistry, vol.279, issue.10, pp.9490-9496, 2004.
DOI : 10.1074/jbc.M311331200

G. Snounou, S. Viriyakosol, X. P. Zhu, W. Jarra, L. Pinheiro et al., High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction, Molecular and Biochemical Parasitology, vol.61, issue.2, pp.315-320, 1993.
DOI : 10.1016/0166-6851(93)90077-B

A. W. Stowers, M. C. Kennedy, B. P. Keegan, A. Saul, C. A. Long et al., Vaccination of monkeys with recombinant Plasmodium falciparum apical membrane antigen 1confers protection against blood-stage malaria, Infect. Immun, vol.12, pp.6961-6967, 2002.

F. Tajima, Statistical method for testing the neutral mutation hypothesis by DNA polymorphism, Genetics, vol.123, pp.585-595, 1989.

L. K. Tan, S. Yacoub, S. Scott, S. Bhagani, and M. Jacobs, Acute lung injury and other serious complications of Plasmodium vivax malaria, The Lancet Infectious Diseases, vol.8, issue.7, pp.449-454, 2008.
DOI : 10.1016/S1473-3099(08)70153-1

G. A. Targett and B. M. Greenwood, Malaria vaccines and their potential role in the elimination of malaria, Malaria Journal, vol.7, issue.Suppl 1, p.10, 2008.
DOI : 10.1186/1475-2875-7-S1-S10

F. Tediosi, N. Maire, M. Penny, A. Studer, and T. A. Smith, Simulation of the cost-effectiveness of malaria vaccines, Malaria Journal, vol.8, issue.1, p.127, 2009.
DOI : 10.1186/1475-2875-8-127

A. Thakur, M. T. Alam, H. Bora, P. Kaur, and Y. D. Sharma, Plasmodium vivax: Sequence polymorphism and effect of natural selection at apical membrane antigen 1 (PvAMA1) among Indian population, Gene, vol.419, issue.1-2, pp.35-42, 2008.
DOI : 10.1016/j.gene.2008.04.012

A. W. Thomas, J. A. Deans, G. H. Mitchell, T. Alderson, and S. Cohen, The Fab fragments of monoclonal IgG to a merozoite surface antigen inhibit Plasmodium knowlesi invasion of erythrocytes, Molecular and Biochemical Parasitology, vol.13, issue.2, pp.187-199, 1984.
DOI : 10.1016/0166-6851(84)90112-9

A. W. Thomas, J. F. Trape, C. Rogier, A. Goncalves, V. E. Rosario et al., High prevalence of natural antibodies against Plasmodium falciparum 83-kilodalton apical membrane antigen (PF83/AMA-1) as detected by capture-enzyme-linked immunosorbent assay using full-length baculovirus recombinant PF83/AMA-1. Am, J. Trop. Med. Hyg, vol.51, pp.730-740, 1994.

E. Tjitra, N. M. Anstey, P. Sugiarto, N. Warikar, E. Kenangalem et al., Multidrug-Resistant Plasmodium vivax Associated with Severe and Fatal Malaria: A Prospective Study in Papua, Indonesia, PLoS Medicine, vol.181, issue.6, p.128, 2008.
DOI : 10.1371/journal.pmed.0050128.t003

T. Triglia, J. Healer, S. R. Caruana, A. N. Hodder, R. F. Anders et al., Apical membrane antigen 1 plays a central role in erythrocyte invasion by Plasmodium species, Molecular Microbiology, vol.91, issue.4, pp.706-718, 2000.
DOI : 10.1073/pnas.93.3.1130

V. Udhayakumar, S. Kariuki, M. Kolczack, M. Girma, J. M. Roberts et al., Longitudinal study of natural immune responses to the Plasmodium falciparum apical membrane antigen (AMA-1) in a holoendemic region of malaria in western Kenya: Asembo Bay Cohort Project VIII. Am, J. Trop. Med. Hyg, vol.65, pp.100-107, 2001.

A. P. Waters, A. W. Thomas, J. A. Deans, G. H. Mitchell, D. E. Hudson et al., A merozoite receptor protein from Plasmodium knowlesi is highly conserved and distributed throughout Plasmodium, J. Biol. Chem, vol.265, pp.17974-17979, 1990.

Z. R. Yang, R. Thomson, P. Mcneil, and R. M. Esnouf, RONN: the bio-basis function neural network technique applied to the detection of natively disordered regions in proteins, Bioinformatics, vol.21, issue.16, pp.3369-3376, 2005.
DOI : 10.1093/bioinformatics/bti534

S. Zakeri, A. A. Mehrizi, N. D. Djadid, and G. Snounou, Circumsporozoite protein gene diversity among temperate and tropical Plasmodium vivax isolates from Iran, Tropical Medicine and International Health, vol.74, issue.3, pp.729-737, 2006.
DOI : 10.1016/0166-6851(93)90077-B

S. Zakeri, A. A. Mehrizi, S. Noorizadeh, N. D. Djadid, and G. Snounou, Population structure analysis of Iranian Plasmodium vivax in areas with different malaria endemicity, Am. J. Trop. Med. Hyg, vol.74, pp.394-400, 2006.

S. Zakeri, H. Barjesteh, and N. D. Djadid, Merozoite surface protein-3a is a reliable marker for population genetic analysis of Plasmodium vivax, Malar. J, vol.3, issue.5, p.53, 2006.