D. Bredt, Endogenous nitric oxide synthesis: Biological functions and pathophysiology, Free Radical Research, vol.100, issue.6, pp.577-96, 1999.
DOI : 10.1016/S0092-8674(00)80513-9

C. Nathan, Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling, Journal of Clinical Investigation, vol.111, issue.6, pp.769-78, 2003.
DOI : 10.1172/JCI200318174

J. Parkinson, B. Mitrovic, and J. Merrill, The role of nitric oxide in multiple sclerosis, Journal of Molecular Medicine, vol.75, issue.3, pp.174-86, 1997.
DOI : 10.1007/s001090050102

T. Touil, M. Deloire-grassin, and C. Vital, In vivo damage of CNS myelin and axons induced by peroxynitrite, Neuroreport, vol.12, issue.16, pp.3637-3681, 2001.
DOI : 10.1097/00001756-200111160-00052

M. Micking, J. Willenberg, D. Weidemann, and M. , Elevated secretion of reactive nitrogen and oxygen intermediates by inflammatory leukocytes in hyperacute experimental autoimmune encephalomyelitis: enhancement by the soluble products of encephalitogenic T cells, Journal of Experimental Medicine, vol.176, issue.1, pp.303-310, 1992.
DOI : 10.1084/jem.176.1.303

R. Gonsette, Neurodegeneration in multiple sclerosis: The role of oxidative stress and excitotoxicity, Journal of the Neurological Sciences, vol.274, issue.1-2, pp.48-53, 2008.
DOI : 10.1016/j.jns.2008.06.029

J. Encinas, L. Manganas, and G. Enikolopov, Nitric oxide and multiple sclerosis, Current Neurology and Neuroscience Reports, vol.24, issue.3, pp.530-532, 2002.
DOI : 10.1007/s11910-005-0051-y

K. Smith and H. Lassmann, The role of nitric oxide in multiple sclerosis, The Lancet Neurology, vol.1, issue.4, pp.232-273, 2002.
DOI : 10.1016/S1474-4422(02)00102-3

A. Cross, P. Manning, and R. Keeling, Peroxynitrite formation within the central nervous system in active multiple sclerosis, Journal of Neuroimmunology, vol.88, issue.1-2, pp.45-56, 1998.
DOI : 10.1016/S0165-5728(98)00078-2

J. Liu, M. Zhao, and C. Brosnan, Expression of Inducible Nitric Oxide Synthase and Nitrotyrosine in Multiple Sclerosis Lesions, The American Journal of Pathology, vol.158, issue.6, pp.2057-66, 2001.
DOI : 10.1016/S0002-9440(10)64677-9

E. Oleszak, E. Zaczynska, and M. Bhattacharjee, Inducible nitric oxide synthase and nitrotyrosine are found in monocytes/macrophages and/or astrocytes in acute, but not in chronic, multiple sclerosis, Clin Diagn Lab Immunol, vol.5, pp.438-483, 1998.

D. Groot, C. Ruuls, S. Theeuwes, and J. , Immunocytochemical Characterization of the Expression of Inducible and Constitutive Isoforms of Nitric Oxide Synthase in Demyelinating Multiple Sclerosis Lesions, Journal of Neuropathology and Experimental Neurology, vol.56, issue.1, pp.10-20, 1997.
DOI : 10.1097/00005072-199701000-00002

K. Hill, L. Zollinger, and H. Watt, Inducible nitric oxide synthase in chronic active multiple sclerosis plaques: distribution, cellular expression and association with myelin damage, Journal of Neuroimmunology, vol.151, issue.1-2, pp.171-180, 2004.
DOI : 10.1016/j.jneuroim.2004.02.005

D. Hooper, O. Bagasra, and J. Marini, Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: Implications for the treatment of multiple sclerosis, Proceedings of the National Academy of Sciences, vol.94, issue.6, pp.2528-2561, 1997.
DOI : 10.1073/pnas.94.6.2528

G. Acar, F. Idiman, and E. Idiman, Nitric oxide as an activity marker in multiple sclerosis, Journal of Neurology, vol.250, issue.5, pp.588-92, 2003.
DOI : 10.1007/s00415-003-1041-0

A. Danilov, M. Andersson, and N. Bavand, Nitric oxide metabolite determinations reveal continuous inflammation in multiple sclerosis, Journal of Neuroimmunology, vol.136, issue.1-2, pp.112-120, 2003.
DOI : 10.1016/S0165-5728(02)00464-2

A. Svenningsson, A. Petersson, and O. Andersen, Nitric oxide metabolites in CSF of patients with MS are related to clinical disease course, Neurology, vol.53, issue.8, pp.1880-1882, 1999.
DOI : 10.1212/WNL.53.8.1880

T. Yamashita, Y. Ando, and K. Obayashi, Changes in nitrite and nitrate (NO2???/NO3???) levels in cerebrospinal fluid of patients with multiple sclerosis, Journal of the Neurological Sciences, vol.153, issue.1, pp.32-36, 1997.
DOI : 10.1016/S0022-510X(97)00183-4

G. Giovannoni, S. Heales, and N. Silver, Raised serum nitrate and nitrite levels in patients with multiple sclerosis, Journal of the Neurological Sciences, vol.145, issue.1, pp.77-81, 1997.
DOI : 10.1016/S0022-510X(96)00246-8

B. Nazliel, D. Taskiran, and C. Irkec, Serum nitric oxide metabolites in patients with multiple sclerosis, Journal of Clinical Neuroscience, vol.9, issue.5, pp.530-532, 2002.
DOI : 10.1054/jocn.2001.1077

F. De-bustos, J. Navarro, and C. De-andres, Cerebrospinal Fluid Nitrate Levels in Patients with Multiple Sclerosis, European Neurology, vol.41, issue.1, pp.44-51, 1999.
DOI : 10.1159/000007997

J. Peltola, M. Ukkonen, and E. Moilanen, Increased nitric oxide products in CSF in primary progressive MS may reflect brain atrophy, Neurology, vol.57, issue.5, pp.895-901, 2001.
DOI : 10.1212/WNL.57.5.895

A. Amirzargar, J. Mytilineos, and S. Scherer, Anilysis Of HLA , DRB1,DRB2,DRB3, DQB1 AND DQA1 frequencies and haplotypes in 43 Iranian multiple sclerosis patients. 19th World Congress of Neurology, Free Paper Abstracts, J Neurol Sci, pp.285-286, 2009.

H. Kalanie, Y. Kholghie, and G. Shamsai, Opticospinal multiple sclerosis in Iran, Journal of the Neurological Sciences, vol.276, issue.1-2, pp.130-132, 2009.
DOI : 10.1016/j.jns.2008.09.038

H. Kalanie, K. Gharagozli, and A. Kalanie, Multiple sclerosis: report on 200 cases from Iran, Multiple Sclerosis Journal, vol.40, issue.1, pp.36-44, 2003.
DOI : 10.1212/WNL.33.11.1444

M. Etemadifar, A. Maghzi, and S. Sadrearhami, Late onset multiple sclerosis in Isfahan, Iran, J Neurol Sci World Congress of Neurology, 2009.

A. Al-araji and A. Mohammed, Multiple sclerosis in Iraq: Does it have the same features encountered in Western countries?, Journal of the Neurological Sciences, vol.234, issue.1-2, pp.67-71, 2005.
DOI : 10.1016/j.jns.2005.03.033

J. Kurtzke, Epidemiologic evidence for multiple sclerosis as an infection., Clinical Microbiology Reviews, vol.6, issue.4, pp.382-427, 1993.
DOI : 10.1128/CMR.6.4.382

M. Sahraian, S. Khorramnia, and Z. Moinfar, FP24-TU-01 Multiple sclerosis in Iran, demographic study of 8000 patients and changes over time, Journal of the Neurological Sciences, vol.285, 2009.
DOI : 10.1016/S0022-510X(09)70390-9

W. Mcdonald, A. Compston, and G. Edan, Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis, Annals of Neurology, vol.70, issue.1, pp.121-128, 2001.
DOI : 10.1002/ana.1032

J. Hevel and M. Marietta, [25] Nitric-oxide synthase assays, Meth Enzymol, vol.233, pp.250-258, 1994.
DOI : 10.1016/S0076-6879(94)33028-X

. Mccarthy, The ???gender gap??? in autoimmune disease, The Lancet, vol.356, issue.9235, p.1088, 2000.
DOI : 10.1016/S0140-6736(05)74535-9

G. Giovannoni, Cerebrospinal fluid and serum nitric oxide metabolites in patients with multiple sclerosis, Multiple Sclerosis Journal, vol.43, issue.1, pp.27-30, 1998.
DOI : 10.1002/ana.410130302