J. Breman, M. Alilio, and A. Mills, Conquering the intolerable burden of malaria: what's new, what's needed: a summary, Am J Trop Med Hyg, vol.71, pp.1-15, 2004.

C. John, P. Bangirana, J. Byarugaba, R. Opoka, R. Idro et al., Cerebral Malaria in Children Is Associated With Long-term Cognitive Impairment, PEDIATRICS, vol.122, issue.1, pp.92-99, 2008.
DOI : 10.1542/peds.2007-3709

S. Mishra and C. Newton, Diagnosis and management of the neurological complications of falciparum malaria, Nature Reviews Neurology, vol.19, issue.4, pp.189-198, 2009.
DOI : 10.1038/nrneurol.2009.23

J. Lou, R. Lucas, and G. Grau, Pathogenesis of Cerebral Malaria: Recent Experimental Data and Possible Applications for Humans, Clinical Microbiology Reviews, vol.14, issue.4, pp.810-820, 2001.
DOI : 10.1128/CMR.14.4.810-820.2001

N. Hunt and G. Grau, Cytokines: accelerators and brakes in the pathogenesis of cerebral malaria, Trends in Immunology, vol.24, issue.9, pp.491-499, 2003.
DOI : 10.1016/S1471-4906(03)00229-1

H. Van-der-heyde, J. Nolan, V. Combes, I. Gramaglia, and G. Grau, A unified hypothesis for the genesis of cerebral malaria: sequestration, inflammation and hemostasis leading to microcirculatory dysfunction, Trends in Parasitology, vol.22, issue.11, pp.503-508, 2006.
DOI : 10.1016/j.pt.2006.09.002

D. Hansen, N. Bernard, C. Nie, and L. Schofield, NK Cells Stimulate Recruitment of CXCR3+ T Cells to the Brain during Plasmodium berghei-Mediated Cerebral Malaria, The Journal of Immunology, vol.178, issue.9, pp.5779-5788, 2007.
DOI : 10.4049/jimmunol.178.9.5779

L. Renia, S. Potter, M. Mauduit, D. Rosa, M. Kayibanda et al., Pathogenic T cells in cerebral malaria, International Journal for Parasitology, vol.36, issue.5, pp.547-554, 2006.
DOI : 10.1016/j.ijpara.2006.02.007

J. Nitcheu, O. Bonduelle, C. Combadiere, M. Tefit, D. Seilhean et al., Perforin-Dependent Brain-Infiltrating Cytotoxic CD8+ T Lymphocytes Mediate Experimental Cerebral Malaria Pathogenesis, The Journal of Immunology, vol.170, issue.4, pp.2221-2228, 2003.
DOI : 10.4049/jimmunol.170.4.2221

S. Mohanty, D. Patel, S. Pati, and S. Mishra, Adjuvant therapy in cerebral malaria, Indian J Med Res, vol.124, pp.245-260, 2006.

M. Terblanche, Y. Almog, R. Rosenson, T. Smith, and D. Hackam, Statins and sepsis: multiple modifications at multiple levels, The Lancet Infectious Diseases, vol.7, issue.5, pp.358-368, 2007.
DOI : 10.1016/S1473-3099(07)70111-1

O. Grip, S. Janciauskiene, and S. Lindgren, Pravastatin down-regulates inflammatory mediators in human monocytes in vitro, European Journal of Pharmacology, vol.410, issue.1, pp.83-92, 2000.
DOI : 10.1016/S0014-2999(00)00870-0

A. Blum and R. Shamburek, The pleiotropic effects of statins on endothelial function, vascular inflammation, immunomodulation and thrombogenesis, Atherosclerosis, vol.203, issue.2, pp.325-330, 2009.
DOI : 10.1016/j.atherosclerosis.2008.08.022

B. Kwak, F. Mulhaupt, S. Myit, and F. Mach, Statins as a newly recognized type of immunomodulator, Nat Med, vol.6, pp.1399-1402, 2000.

F. Mulhaupt, C. Matter, B. Kwak, G. Pelli, N. Veillard et al., Statins (HMG-CoA reductase inhibitors) reduce CD40 expression in human vascular cells, Cardiovascular Research, vol.59, issue.3, pp.755-766, 2003.
DOI : 10.1016/S0008-6363(03)00515-7

A. Wagner, M. Gebauer, B. Guldenzoph, and M. Hecker, 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase-Independent Inhibition of CD40 Expression by Atorvastatin in Human Endothelial Cells, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.22, issue.11, pp.1784-1789, 2002.
DOI : 10.1161/01.ATV.0000037098.20829.31

P. Raemer, K. Kohl, and C. Watzl, Statins inhibit NK‐cell cytotoxicity by interfering with LFA‐1‐mediated conjugate formation, European Journal of Immunology, vol.120, issue.6, pp.1456-1465, 2009.
DOI : 10.1002/eji.200838863

H. Ando, T. Takamura, T. Ota, Y. Nagai, and K. Kobayashi, Cerivastatin improves survival of mice with lipopolysaccharide-induced sepsis, J Pharmacol Exp Ther, vol.294, pp.1043-1046, 2000.

K. Huang, C. Chen, J. Chen, and W. Lin, HMG-CoA reductase inhibitors inhibit inducible nitric oxide synthase gene expression in macrophages, Journal of Biomedical Science, vol.126, issue.4, pp.396-405, 2003.
DOI : 10.1007/BF02256431

A. Giusti-paiva, M. Martinez, J. Felix, M. Da-rocha, E. Carnio et al., Simvastatin Decreases Nitric Oxide Overproduction and Reverts the Impaired Vascular Responsiveness Induced by Endotoxic Shock in Rats, Shock, vol.21, issue.3, pp.271-275, 2004.
DOI : 10.1097/10.shk.0000115756.74059.ce

L. Rasmussen, P. Hansen, M. Nabipour, P. Olesen, M. Kristiansen et al., Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cells, Biochemical Journal, vol.360, issue.2, pp.363-370, 2001.
DOI : 10.1042/bj3600363

A. Rezaie-majd, G. Prager, R. Bucek, G. Schernthaner, T. Maca et al., Simvastatin Reduces the Expression of Adhesion Molecules in Circulating Monocytes From Hypercholesterolemic Patients, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.23, issue.3, pp.397-403, 2003.
DOI : 10.1161/01.ATV.0000059384.34874.F0

Z. Taoufiq, P. Pino, N. Dilimabaka, N. Arrouss, I. Assi et al., Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage, Malaria Journal, vol.10, issue.1, p.52, 2011.
DOI : 10.1016/j.exppara.2010.01.005
URL : https://hal.archives-ouvertes.fr/inserm-00663669

M. Merx, E. Liehn, J. Graf, A. Van-de-sandt, M. Schaltenbrand et al., Statin Treatment After Onset of Sepsis in a Murine Model Improves Survival, Circulation, vol.112, issue.1, pp.117-124, 2005.
DOI : 10.1161/CIRCULATIONAHA.104.502195

P. Kopterides and M. Falagas, Statins for sepsis: a critical and updated review, Clinical Microbiology and Infection, vol.15, issue.4, pp.325-334, 2009.
DOI : 10.1111/j.1469-0691.2009.02750.x

M. Moonis, K. Kane, U. Schwiderski, B. Sandage, and M. Fisher, HMG-CoA Reductase Inhibitors Improve Acute Ischemic Stroke Outcome, Stroke, vol.36, issue.6, pp.1298-1300, 2005.
DOI : 10.1161/01.STR.0000165920.67784.58

I. Clark, L. Alleva, A. Mills, and W. Cowden, Pathogenesis of Malaria and Clinically Similar Conditions, Clinical Microbiology Reviews, vol.17, issue.3, pp.509-539, 2004.
DOI : 10.1128/CMR.17.3.509-539.2004

B. Pradines, M. Torrentino-madamet, A. Fontaine, M. Henry, E. Baret et al., Atorvastatin Is 10-Fold More Active In Vitro than Other Statins against Plasmodium falciparum, Antimicrobial Agents and Chemotherapy, vol.51, issue.7, pp.2654-2655, 2007.
DOI : 10.1128/AAC.01330-06

V. Parquet, S. Briolant, M. Torrentino-madamet, M. Henry, L. Almeras et al., Atorvastatin Is a Promising Partner for Antimalarial Drugs in Treatment of Plasmodium falciparum Malaria, Antimicrobial Agents and Chemotherapy, vol.53, issue.6, pp.2248-2252, 2009.
DOI : 10.1128/AAC.01462-08

R. Kobbe, N. Schreiber, M. J. Jacobs, and T. , Simvastatin Treatment Shows No Effect on the Incidence of Cerebral Malaria or Parasitemia during Experimental Malaria, Antimicrobial Agents and Chemotherapy, vol.52, issue.4, pp.1583-1584, 2008.
DOI : 10.1128/AAC.01428-07

N. Wurtz, S. Briolant, M. Gil, V. Parquet, M. Henry et al., Synergy of mefloquine activity with atorvastatin, but not chloroquine and monodesethylamodiaquine, and association with the pfmdr1 gene, Journal of Antimicrobial Chemotherapy, vol.65, issue.7, pp.1387-1394, 2010.
DOI : 10.1093/jac/dkq173

V. Parquet, M. Henry, N. Wurtz, J. Dormoi, S. Briolant et al., Atorvastatin as a potential anti-malarial drug: in vitro synergy in combinational therapy with quinine against Plasmodium falciparum, Malaria Journal, vol.9, issue.1, p.139, 2010.
DOI : 10.1186/1475-2875-9-139

H. Savini, J. Souraud, S. Briolant, E. Baret, R. Amalvict et al., Atorvastatin as a Potential Antimalarial Drug: In Vitro Synergy in Combinational Therapy with Dihydroartemisinin, Antimicrobial Agents and Chemotherapy, vol.54, issue.2, pp.966-967, 2010.
DOI : 10.1128/AAC.01006-09

V. Borek-dohalsky, J. Huclova, B. Barrett, B. Nemec, I. Ulc et al., Validated HPLC???MS???MS method for simultaneous determination of atorvastatin and 2-hydroxyatorvastatin in human plasma???pharmacokinetic study, Analytical and Bioanalytical Chemistry, vol.35, issue.2, pp.275-285, 2006.
DOI : 10.1007/s00216-006-0655-3

N. Delahaye, N. Coltel, D. Puthier, M. Barbier, P. Benech et al., Gene expression analysis reveals early changes in several molecular pathways in cerebral malaria-susceptible mice versus cerebral malaria-resistant mice, BMC Genomics, vol.8, issue.1, p.452, 2007.
DOI : 10.1186/1471-2164-8-452

P. Lackner, R. Beer, V. Heussler, G. Goebel, D. Rudzki et al., Behavioural and histopathological alterations in mice with cerebral malaria, Neuropathology and Applied Neurobiology, vol.50, issue.2, pp.177-188, 2006.
DOI : 10.1136/jnnp.69.4.433

A. Bienvenu and S. Picot, Statins Alone Are Ineffective in Cerebral Malaria but Potentiate Artesunate, Antimicrobial Agents and Chemotherapy, vol.52, issue.11, pp.4203-4204, 2008.
DOI : 10.1128/AAC.00513-08

A. Helmers, D. Gowda, K. Kain, and W. Liles, Statins Fail to Improve Outcome in Experimental Cerebral Malaria and Potentiate Toll-Like Receptor-Mediated Cytokine Production by Murine Macrophages, American Journal of Tropical Medicine and Hygiene, vol.81, issue.4, pp.631-637, 2009.
DOI : 10.4269/ajtmh.2009.09-0204

Y. Martins, L. Carvalho, and C. Daniel-ribeiro, Challenges in the Determination of Early Predictors of Cerebral Malaria: Lessons from the Human Disease and the Experimental Murine Models, Neuroimmunomodulation, vol.16, issue.2, pp.134-145, 2009.
DOI : 10.1159/000180268

L. Carvalho, H. Lenzi, M. Pelajo-machado, D. Oliveira, C. Daniel-ribeiro et al., Plasmodium berghei: Cerebral Malaria in CBA Mice Is Not Clearly Related to Plasma TNF Levels or Intensity of Histopathological Changes, Experimental Parasitology, vol.95, issue.1, pp.1-7, 2000.
DOI : 10.1006/expr.2000.4508

V. Jennings, A. Lal, and R. Hunter, Evidence for multiple pathologic and protective mechanisms of murine cerebral malaria, Infect Immun, vol.66, pp.5972-5979, 1998.

L. Wiese, J. Kurtzhals, and M. Penkowa, Neuronal apoptosis, metallothionein expression and proinflammatory responses during cerebral malaria in mice, Experimental Neurology, vol.200, issue.1, pp.216-226, 2006.
DOI : 10.1016/j.expneurol.2006.02.011

A. Dondorp, F. Nosten, P. Yi, D. Das, A. Phyo et al., Malaria, New England Journal of Medicine, vol.361, issue.5, pp.455-467, 2009.
DOI : 10.1056/NEJMoa0808859
URL : https://hal.archives-ouvertes.fr/hal-01199794