M. D. Cooper and M. N. Alder, The Evolution of Adaptive Immune Systems, Cell, vol.124, issue.4, pp.815-822, 2006.
DOI : 10.1016/j.cell.2006.02.001

J. Stavnezer, J. E. Guikema, and C. E. Schrader, Mechanism and Regulation of Class Switch Recombination, Annual Review of Immunology, vol.26, issue.1, pp.261-292, 2008.
DOI : 10.1146/annurev.immunol.26.021607.090248

Z. Xu, H. Zan, E. J. Pone, T. Mai, and P. Casali, Immunoglobulin classswitch DNA recombination: induction, targeting and beyond, Nat. Rev
DOI : 10.1038/nri3216

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545482

M. Muramatsu, K. Kinoshita, S. Fagarasan, S. Yamada, Y. Shinkai et al., Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme, Cell, vol.102, issue.5, pp.553-563, 2000.
DOI : 10.1016/S0092-8674(00)00078-7

M. B. Litinskiy, B. Nardelli, D. M. Hilbert, B. He, A. A. Schäffersch¨schäffer et al., DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL, Nature Immunology, vol.3, issue.9, pp.822-829, 2002.
DOI : 10.1038/ni829

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621779

P. Schneider, The role of APRIL and BAFF in lymphocyte activation, Current Opinion in Immunology, vol.17, issue.3, pp.282-289, 2005.
DOI : 10.1016/j.coi.2005.04.005

E. Castigli, S. A. Wilson, A. Elkhal, E. Ozcan, L. Garibyan et al., Transmembrane activator and calcium modulator and cyclophilin ligand interactor enhances CD40-driven plasma cell differentiation, Journal of Allergy and Clinical Immunology, vol.120, issue.4
DOI : 10.1016/j.jaci.2007.06.012

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2121612

E. Ozcan, I. Rauter, L. Garibyan, S. R. Dillon, and R. S. Geha, Toll-like receptor 9, transmembrane activator and calcium-modulating cyclophilin ligand interactor, and CD40 synergize in causing B-cell activation, Journal of Allergy and Clinical Immunology, vol.128, issue.3, pp.601-609, 2011.
DOI : 10.1016/j.jaci.2011.04.052

S. Fagarasan and T. Honjo, T-Independent Immune Response: New Aspects of B Cell Biology, Science, vol.290, issue.5489, pp.89-92, 2000.
DOI : 10.1126/science.290.5489.89

B. He, W. Xu, P. A. Santini, A. D. Polydorides, A. Chiu et al., Intestinal Bacteria Trigger T Cell-Independent Immunoglobulin A2 Class Switching by Inducing Epithelial-Cell Secretion of the Cytokine APRIL, Immunity, vol.26, issue.6, pp.812-826, 2007.
DOI : 10.1016/j.immuni.2007.04.014

N. 11-katsenelson, S. Kanswal, M. Puig, H. Mostowski, D. Verthelyi et al., Synthetic CpG oligodeoxynucleotides augment BAFF- and APRIL-mediated immunoglobulin secretion, European Journal of Immunology, vol.25, issue.7, pp.1785-1795, 2007.
DOI : 10.1002/eji.200636800

B. He, R. Santamaria, W. Xu, M. Cols, K. Chen et al., The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88, Nature Immunology, vol.181, issue.9, pp.836-845, 2010.
DOI : 10.1084/jem.20030701

E. Castigli, S. A. Wilson, L. Garibyan, R. Rachid, F. Bonilla et al., TACI is mutant in common variable immunodeficiency and IgA deficiency, Nature Genetics, vol.169, issue.8, pp.829-834, 2005.
DOI : 10.1038/ng1601

U. Salzer, H. M. Chapel, A. D. Webster, Q. Pan-hammarstrom, A. Schmitt-graeff et al., Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans, Nature Genetics, vol.53, issue.8, pp.820-828, 2005.
DOI : 10.1038/ng1600

C. Cunningham-rundles and C. Bodian, Common Variable Immunodeficiency: Clinical and Immunological Features of 248 Patients, Clinical Immunology, vol.92, issue.1, pp.34-48, 1999.
DOI : 10.1006/clim.1999.4725

C. Wehr, H. H. Peter, and K. Warnatz, Response: Improving classification in CVID, Blood, vol.112, issue.2, pp.446-447, 2008.
DOI : 10.1182/blood-2008-05-149997

M. B. Almejun, E. Sajaroff, M. Galicchio, M. Oleastro, A. Bernasconi et al., Immunological Characteristics and Two Novel Mutations in TACI in a Cohort of 28 Pediatric Patients with Common Variable Immunodeficiency, Journal of Clinical Immunology, vol.121, issue.1, pp.89-97, 2012.
DOI : 10.1007/s10875-011-9613-8

K. H. Hammarströmhammarstr¨hammarström and L. , Alternative end joining during switch recombination in patients with Ataxia-Telangiectasia, Eur. J. Immunol, vol.32, pp.1300-1308, 2002.

C. 19-bossen and P. Schneider, BAFF, APRIL and their receptors: Structure, function and signaling, Seminars in Immunology, vol.18, issue.5, pp.263-275, 2006.
DOI : 10.1016/j.smim.2006.04.006

C. Cunningham-rundles, L. Radigan, A. K. Knight, L. Zhang, L. Bauer et al., TLR9 Activation Is Defective in Common Variable Immune Deficiency, The Journal of Immunology, vol.176, issue.3, pp.1978-1987, 2006.
DOI : 10.4049/jimmunol.176.3.1978

J. J. Lee, I. Rauter, L. Garibyan, E. Ozcan, T. Sannikova et al., The murine equivalent of the A181E TACI mutation associated with common variable immunodeficiency severely impairs B-cell function, Blood, vol.114, issue.11, pp.2254-2262, 2009.
DOI : 10.1182/blood-2008-11-189720

U. Siebenlist, K. Brown, C. , and E. , Control of lymphocyte development by nuclear factor-??B, Nature Reviews Immunology, vol.11, issue.6, pp.435-445, 2005.
DOI : 10.1084/jem.20020062

F. Dedeoglu, B. Horwitz, J. Chaudhuri, F. W. Alt, and R. S. Geha, Induction of activation-induced cytidine deaminase gene expression by IL-4

A. J. Fried, I. Rauter, S. R. Dillon, H. Jabara, and R. S. Geha, Functional analysis of transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) mutations associated with common variable immunodeficiency, Journal of Allergy and Clinical Immunology, vol.128, issue.1, pp.226-228, 2011.
DOI : 10.1016/j.jaci.2011.01.048

C. L. Ku, H. Von-bernuth, C. Picard, S. Y. Zhang, H. H. Chang et al., Selective predisposition to bacterial infections in IRAK-4???deficient children: IRAK-4???dependent TLRs are otherwise redundant in protective immunity, The Journal of Experimental Medicine, vol.104, issue.10, pp.2407-2422, 2007.
DOI : 10.1084/jem.20060085

URL : https://hal.archives-ouvertes.fr/hal-00297302

C. Vinuesa, M. A. Linterman, C. C. Goodnow, and K. L. Randall, T cells and follicular dendritic cells in germinal center B-cell formation and selection, Immunological Reviews, vol.446, issue.1, pp.72-89, 2010.
DOI : 10.1111/j.1600-065X.2010.00937.x

C. Bossen, T. G. Cachero, A. Tardivel, K. Ingold, L. Willen et al., TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts, Blood, vol.111, issue.3, pp.1004-1012, 2008.
DOI : 10.1182/blood-2007-09-110874

X. Z. 29-xia, J. Treanor, G. Senaldi, S. D. Khare, T. Boone et al., Taci Is a Traf-Interacting Receptor for Tall-1, a Tumor Necrosis Factor Family Member Involved in B Cell Regulation, The Journal of Experimental Medicine, vol.65, issue.1, pp.137-143, 2000.
DOI : 10.1038/35010115

H. Ye and H. Wu, Thermodynamic characterization of the interaction between TRAF2 and tumor necrosis factor receptor peptides by isothermal titration calorimetry, Proc. Natl. Acad. Sci, pp.8961-8966, 2000.
DOI : 10.1073/pnas.160241997

V. Baud, Z. G. Liu, B. Bennett, N. Suzuki, Y. Xia et al., Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain, Genes & Development, vol.13, issue.10, pp.1297-1308, 1999.
DOI : 10.1101/gad.13.10.1297

U. Salzer, C. Bacchelli, S. Buckridge, Q. Pan-hammarströmhammarstr¨hammarström, S. Jennings et al., Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes, Blood, vol.113, issue.9, pp.1967-1976, 2009.
DOI : 10.1182/blood-2008-02-141937

A. Magerus-chatinet, B. Neven, M. C. Stolzenberg, C. Daussy, P. Arkwright et al., Onset of autoimmune lymphoproliferative syndrome (ALPS) in humans as a consequence of genetic defect accumulation, Journal of Clinical Investigation, vol.121, issue.1, pp.106-112, 2011.
DOI : 10.1172/JCI43752DS1

Q. 34-pan-hammarströmhammarstr¨hammarström, S. Dai, Y. Zhao, . Dijk-hard, R. A. Gatti et al., ATM Is Not Required in Somatic Hypermutation of VH, but Is Involved in the Introduction of Mutations in the Switch ?? Region, The Journal of Immunology, vol.170, issue.7, pp.3707-3716, 2003.
DOI : 10.4049/jimmunol.170.7.3707

W. Xu, P. A. Santini, A. J. Matthews, A. Chiu, A. Plebani et al., Viral Double-Stranded RNA Triggers Ig Class Switching by Activating Upper Respiratory Mucosa B Cells through an Innate TLR3 Pathway Involving BAFF, The Journal of Immunology, vol.181, issue.1, pp.276-287, 2008.
DOI : 10.4049/jimmunol.181.1.276

J. Mohammadi, C. Liu, A. Aghamohammadi, A. Bergbreiter, L. Du et al., Novel Mutations in TACI (TNFRSF13B) Causing Common Variable Immunodeficiency, Journal of Clinical Immunology, vol.154, issue.1, pp.777-785, 2009.
DOI : 10.1007/s10875-009-9317-5