S. G. Afonso, C. F. Polo, R. Enriquez-de-salamanca, and A. Batlle, Mechanistic studies on uroporphyrin I-induced photoinactivation of some heme-enzymes, The International Journal of Biochemistry & Cell Biology, vol.28, issue.4, 1996.
DOI : 10.1016/1357-2725(95)00159-X

S. Brisse, C. Barnabé, and M. Tibayrenc, Trypanosoma cruzi: How Many Relevant Phylogenetic Subdivisions are There?, Parasitology Today, vol.14, issue.5, pp.178-179, 1998.
DOI : 10.1016/S0169-4758(98)01225-3

O. Castellani, L. V. Ribeiro, and J. F. Fernandes, in Culture*, The Journal of Protozoology, vol.6, issue.3, pp.447-451, 1967.
DOI : 10.1111/j.1550-7408.1967.tb02024.x

H. Castro, C. Sousa, M. Santos, A. Cordeiro-da-silva, L. Flohe et al., Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum, Free Radical Biology and Medicine, vol.33, issue.11, pp.1552-1562, 2002.
DOI : 10.1016/S0891-5849(02)01089-4

P. Cuervo, J. B. De-jesus, L. Saboia-vahia, L. Mendonça-lima, G. B. Domont et al., Proteomic characterization of the released/secreted proteins of Leishmania (Viannia) braziliensis promastigotes, Journal of Proteomics, vol.73, issue.1, pp.79-92, 2009.
DOI : 10.1016/j.jprot.2009.08.006

E. Dumonteil, Vaccine development against Trypanosoma cruzi and Leishmania species in the post-genomic era, Infection, Genetics and Evolution, vol.9, issue.6, pp.1075-1082, 2009.
DOI : 10.1016/j.meegid.2009.02.009

J. A. Dvorak, J. C. Engel, R. D. Leapman, C. R. Swyt, and P. A. Pella, Trypanosoma cruzi: elemental composition heterogeneity of cloned stocks, Molecular and Biochemical Parasitology, vol.31, issue.1, pp.19-26, 1988.
DOI : 10.1016/0166-6851(88)90141-7

M. L. Díaz, A. Solari, and C. I. González, Differential expression of Trypanosoma cruzi I associated with clinical forms of Chagas disease: Overexpression of oxidative stress proteins in acute patient isolate, Journal of Proteomics, vol.74, issue.9, pp.1673-1682, 2011.
DOI : 10.1016/j.jprot.2011.05.001

E. Fakhry, Y. Ouellette, M. Papadopoulou, and B. , A proteomic approach to identify developmentally regulated proteins in Leishmania infantum, PROTEOMICS, vol.2, issue.8, pp.1007-1017, 2002.
DOI : 10.1002/1615-9861(200208)2:8<1007::AID-PROT1007>3.0.CO;2-G

J. C. Engel, P. S. Doyle, and J. A. Dvorak, Isolate-dependent differences in the oxidative metabolism of Trypanosoma cruzi epimastigotes, Molecular and Biochemical Parasitology, vol.39, issue.1, pp.69-76, 1990.
DOI : 10.1016/0166-6851(90)90009-B

J. K. Finzi, C. W. Chiavegatto, K. F. Corat, J. A. Lopez, O. G. Cabrera et al., Trypanosoma cruzi response to the oxidative stress generated by hydrogen peroxide, Molecular and Biochemical Parasitology, vol.133, issue.1, pp.37-43, 2004.
DOI : 10.1016/j.molbiopara.2003.08.011

L. Flohe, H. J. Hecht, and P. Steinert, Glutathione and trypanothione in parasitic hydroperoxide metabolism. Free Radic, Biol. Med, vol.27, pp.966-984, 1999.

A. Geiger, C. Hirtz, T. Bécue, E. Bellard, D. Centeno et al., Exocytosis and protein secretion in Trypanosoma, BMC Microbiology, vol.10, issue.1, p.20, 2010.
DOI : 10.1186/1471-2180-10-20

M. F. Gonçalves, E. S. Umezawa, A. M. Katzin, W. De-souza, M. J. Alves et al., Trypanosoma cruzi: Shedding of surface antigens as membrane vesicles, Experimental Parasitology, vol.72, issue.1, pp.43-53, 1991.
DOI : 10.1016/0014-4894(91)90119-H

F. Irigoín, L. Cibils, M. A. Comini, S. R. Wilkinson, L. Flohé et al., Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification, Free Radical Biology and Medicine, vol.45, issue.6, pp.733-742, 2008.
DOI : 10.1016/j.freeradbiomed.2008.05.028

F. Kierszenbaum, E. Knecht, D. B. Budzko, and M. C. Pizzimenti, Phagocytosis: a defense mechanism against infection with Trypanosoma cruzi, J. Immunol, vol.112, pp.1839-1844, 1974.

R. L. Krauth-siegel and M. A. Comini, Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1780, issue.11, pp.1236-1248, 2008.
DOI : 10.1016/j.bbagen.2008.03.006

S. Kumar and U. Bandyopadhyay, Free heme toxicity and its detoxification systems in human, Toxicology Letters, vol.157, issue.3, pp.175-188, 2005.
DOI : 10.1016/j.toxlet.2005.03.004

W. Nickel, Unconventional Secretory Routes: Direct Protein Export Across the Plasma Membrane of Mammalian Cells, Traffic, vol.166, issue.10, pp.607-614, 2005.
DOI : 10.1016/0968-0004(90)90186-F

W. Nickel and C. Rabouille, Mechanisms of regulated unconventional protein secretion, Nature Reviews Molecular Cell Biology, vol.133, issue.2, pp.148-155, 2009.
DOI : 10.1038/nrm2617

W. Nickel, Pathways of unconventional protein secretion, Current Opinion in Biotechnology, vol.21, issue.5, pp.621-626, 2010.
DOI : 10.1016/j.copbio.2010.06.004

F. B. Nogueira, M. A. Krieger, P. Nirdé, S. Goldenberg, A. J. Romanha et al., Increased expression of iron-containing superoxide dismutase-A (TcFeSOD-A) enzyme in Trypanosoma cruzi population with in vitro-induced resistance to benznidazole, Acta Tropica, vol.100, issue.1-2, pp.119-132, 2006.
DOI : 10.1016/j.actatropica.2006.10.004

J. Paba, J. M. Santana, A. R. Teixeira, W. Fontes, M. V. Sousa et al., Proteomic analysis of the human pathogenTrypanosoma cruzi, PROTEOMICS, vol.4, issue.4, pp.1052-1059, 2004.
DOI : 10.1002/pmic.200300637

M. C. Paes, D. Cosentino-gomes, C. F. De-souza, N. P. Nogueira, and J. R. Meyer-fernandes, The role of heme and reactive oxygen species in proliferation and survival of Trypanosoma cruzi, J. Parasitol. Res, p.174614, 2011.

P. Ede, F. Vitor, S. C. Ribeiro, L. H. Piñeyro, M. D. Robello et al., Role of Trypanosoma cruzi peroxiredoxins in mitochondrial bioenergetics, J. Bioenerg. Biomembr, vol.43, pp.419-424, 2011.

L. Piacenza, G. Peluffo, M. N. Alvarez, J. M. Kelly, S. R. Wilkinson et al., against macrophage- and endogenously-derived peroxynitrite, Biochemical Journal, vol.410, issue.2, pp.359-368, 2008.
DOI : 10.1042/BJ20071138

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441817

L. Piacenza, M. N. Alvarez, G. Peluffo, and R. Radi, Fighting the oxidative assault: the Trypanosoma cruzi journey to infection, Current Opinion in Microbiology, vol.12, issue.4, pp.415-421, 2009.
DOI : 10.1016/j.mib.2009.06.011

L. Piacenza, M. P. Zago, G. Peluffo, M. N. Alvarez, M. A. Basombrio et al., Enzymes of the antioxidant network as novel determiners of Trypanosoma cruzi virulence, International Journal for Parasitology, vol.39, issue.13, pp.1455-1464, 2009.
DOI : 10.1016/j.ijpara.2009.05.010

M. D. Piñeyro, A. Parodi-talice, T. Arcari, and C. Robello, Peroxiredoxins from Trypanosoma cruzi: Virulence factors and drug targets for treatment of Chagas disease?, Gene, vol.408, issue.1-2, pp.45-50, 2008.
DOI : 10.1016/j.gene.2007.10.014

M. D. Pineyro, T. Arcari, C. Robello, R. Radi, and M. Trujillo, Tryparedoxin peroxidases from Trypanosoma cruzi: High efficiency in the catalytic elimination of hydrogen peroxide and peroxynitrite, Archives of Biochemistry and Biophysics, vol.507, issue.2, pp.287-295, 2011.
DOI : 10.1016/j.abb.2010.12.014

URL : https://hal.archives-ouvertes.fr/pasteur-00685056

S. G. Rhee, K. S. Yang, S. W. Kang, H. A. Woo, and T. S. Chang, : Regulation of Peroxiredoxin, Catalase, and Glutathione Peroxidase via Post-translational Modification, Antioxidants & Redox Signaling, vol.7, issue.5-6, pp.619-626, 2005.
DOI : 10.1089/ars.2005.7.619

M. W. Robinson, A. T. Hutchinson, J. P. Dalton, and S. Donnelly, Peroxiredoxin: a central player in immune modulation, Parasite Immunology, vol.10, issue.9, pp.305-313, 2010.
DOI : 10.1111/j.1365-3024.2010.01201.x

Y. Tanaka, H. Tanowitz, and B. R. Bloom, Growth of Trypanosoma cruzi in a cloned macrophage cell line and in a variant defective in oxygen metabolism, Infect. Immun, vol.41, pp.1322-1331, 1983.

T. Torrecilhas, A. C. Tonelli, R. R. Pavanelli, W. R. Da-silva, J. S. Schumacher et al., Trypanosoma cruzi: parasite shed vesicles increase heart parasitism and generate an intense inflammatory response, Microbes and Infection, vol.11, issue.1, pp.29-39, 2009.
DOI : 10.1016/j.micinf.2008.10.003

S. R. Wilkinson, N. J. Temperton, A. Mondragon, and J. M. Kelly, Distinct Mitochondrial and Cytosolic Enzymes Mediate Trypanothione-dependent Peroxide Metabolism in Trypanosoma cruzi, Journal of Biological Chemistry, vol.275, issue.11, pp.8220-8225, 2000.
DOI : 10.1074/jbc.275.11.8220

S. R. Wilkinson, M. C. Taylor, S. Touitha, I. L. Mauricio, D. J. Meyer et al., TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum, Biochemical Journal, vol.364, issue.3, pp.787-794, 2002.
DOI : 10.1042/bj20020038

S. R. Wilkinson, D. J. Meyer, M. C. Taylor, E. V. Bromley, M. A. Miles et al., The Trypanosoma cruzi Enzyme TcGPXI Is a Glycosomal Peroxidase and Can Be Linked to Trypanothione Reduction by Glutathione or Tryparedoxin, Journal of Biological Chemistry, vol.277, issue.19, pp.17062-17071, 2002.
DOI : 10.1074/jbc.M111126200

S. R. Wilkinson and J. M. Kelly, The Role of Glutathione Peroxidases in Trypanosomatids, Biological Chemistry, vol.384, issue.4, pp.517-525, 2003.
DOI : 10.1515/BC.2003.060

S. R. Wilkinson, M. C. Taylor, D. Horn, J. M. Kelly, and I. Cheeseman, A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes, Proc. Natl. Acad. Sci. USA 105, pp.5022-5027, 2008.
DOI : 10.1073/pnas.0711014105