R. 1. Ohtsubo, K. Marth, and J. , Glycosylation in Cellular Mechanisms of Health and Disease, Cell, vol.126, issue.5, pp.855-867, 2006.
DOI : 10.1016/j.cell.2006.08.019

S. Baldus, K. Engelmann, and F. Hanisch, MUC1 and the MUCs: A Family of Human Mucins with Impact in Cancer Biology, Critical Reviews in Clinical Laboratory Sciences, vol.61, issue.1, pp.189-23110, 1080.
DOI : 10.1046/j.1365-2141.2003.04038.x

D. Kufe, Mucins in cancer: function, prognosis and therapy, Nature Reviews Cancer, vol.34, issue.12, pp.874-885, 2009.
DOI : 10.1038/nrc2761

S. Tsuboi, S. Hatakeyama, C. Ohyama, and M. Fukuda, Two opposing roles of O-glycans in tumor metastasis, Trends in Molecular Medicine, vol.18, issue.4, pp.224-232, 2012.
DOI : 10.1016/j.molmed.2012.02.001

G. Rabinovich, Y. Van-kooyk, and B. Cobb, Glycobiology of immune responses, Annals of the New York Academy of Sciences, vol.402, issue.1, 2012.
DOI : 10.1111/j.1749-6632.2012.06492.x

T. Hagen, K. Fritz, T. Tabak, and L. , All in the family: the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, Glycobiology, vol.13, issue.1, pp.1-16, 2003.
DOI : 10.1093/glycob/cwg007

I. Brockhausen, Mucin-type O-glycans in human colon and breast cancer: glycodynamics and functions, EMBO reports, vol.5, issue.6, pp.599-604, 2006.
DOI : 10.1139/o04-058

T. Ju and R. Cummings, A unique molecular chaperone Cosmc required for activity of the mammalian core 1 ??3-galactosyltransferase, Proceedings of the National Academy of Sciences, vol.99, issue.26, pp.16613-16618262438199, 2002.
DOI : 10.1073/pnas.262438199

R. Mi, L. Song, Y. Wang, X. Ding, J. Zeng et al., Epigenetic Silencing of the Chaperone Cosmc in Human Leukocytes Expressing Tn Antigen, Journal of Biological Chemistry, vol.287, issue.49, pp.41523-41533, 2012.
DOI : 10.1074/jbc.M112.371989

A. Schietinger, M. Philip, B. Yoshida, P. Azadi, H. Liu et al., A Mutant Chaperone Converts a Wild-Type Protein into a Tumor-Specific Antigen, Science, vol.314, issue.5797, pp.304-308, 2006.
DOI : 10.1126/science.1129200

T. Ju, G. Lanneau, T. Gautam, Y. Wang, B. Xia et al., Human Tumor Antigens Tn and Sialyl Tn Arise from Mutations in Cosmc, Cancer Research, vol.68, issue.6, pp.1636-1646, 2008.
DOI : 10.1158/0008-5472.CAN-07-2345

T. Freire, S. Bay, V. Mensdorff-pouilly, S. Osinaga, and E. , Molecular basis of incomplete O-glycan synthesis in breast cancer cells: putative role of MUC6 in Tn antigen expression, Cancer Res, vol.65, pp.7880-7887, 2005.
URL : https://hal.archives-ouvertes.fr/pasteur-00166792

G. Springer, T and Tn, general carcinoma autoantigens, Science, vol.224, issue.4654, pp.1198-1206, 1984.
DOI : 10.1126/science.6729450

Y. Cao, A. Merling, U. Karsten, S. Goletz, M. Punzel et al., Expression of CD175 (Tn), CD175s (sialosyl-Tn) and CD176 (Thomsen-Friedenreich antigen) on malignant human hematopoietic cells, International Journal of Cancer, vol.86, issue.1, pp.89-99, 2008.
DOI : 10.1002/ijc.23493

S. Itzkowitz, E. Bloom, T. Lau, and Y. Kim, Mucin associated Tn and sialosyl-Tn antigen expression in colorectal polyps., Gut, vol.33, issue.4, pp.518-523, 1992.
DOI : 10.1136/gut.33.4.518

A. Babino, P. Oppezzo, S. Bianco, E. Barrios, N. Berois et al., Tn antigen is a pre-cancerous biomarker in breast tissue and serum inn-nitrosomethylurea-induced rat mammary carcinogenesis, 6\753::AID-IJC1[3.0.CO, pp.753-7591097, 2000.
DOI : 10.1002/(SICI)1097-0215(20000615)86:6<753::AID-IJC1>3.0.CO;2-#

G. Springer, Immunoreactive T and Tn epitopes in cancer diagnosis, prognosis, and immunotherapy, Journal of Molecular Medicine, vol.75, issue.8, pp.594-602, 1997.
DOI : 10.1007/s001090050144

R. Lo-man, S. Vichier-guerre, R. Perraut, E. Dériaud, V. Huteau et al., A Fully Synthetic Therapeutic Vaccine Candidate Targeting Carcinoma-Associated Tn Carbohydrate Antigen Induces Tumor-Specific Antibodies in Nonhuman Primates, Cancer Research, vol.64, issue.14, pp.4987-4994, 2004.
DOI : 10.1158/0008-5472.CAN-04-0252

URL : https://hal.archives-ouvertes.fr/pasteur-00166848

M. Tarp and H. Clausen, Mucin-type O-glycosylation and its potential use in drug and vaccine development, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1780, issue.3, pp.546-563, 2008.
DOI : 10.1016/j.bbagen.2007.09.010

T. Ju, V. Otto, and R. Cummings, The Tn Antigen-Structural Simplicity and Biological Complexity, Angewandte Chemie International Edition, vol.88, issue.8, pp.1770-1791, 2011.
DOI : 10.1002/anie.201002313

J. Manimala, Z. Li, A. Jain, S. Vedbrat, and J. Gildersleeve, Carbohydrate Array Analysis of Anti-Tn Antibodies and Lectins Reveals Unexpected Specificities: Implications for Diagnostic and Vaccine Development, ChemBioChem, vol.203, issue.12, pp.2229-2241, 2005.
DOI : 10.1002/cbic.200500165

J. Huang, J. Byrd, B. Siddiki, M. Yuan, E. Lau et al., Monoclonal antibodies against partially deglycosylated colon cancer mucin that recognize Tn antigen, Dis Markers, vol.10, pp.81-94, 1992.

S. Itzkowitz, T. Kjeldsen, A. Friera, S. Hakomori, U. Yang et al., Expression of Tn, sialosyl Tn, and T antigens in human pancreas, Gastroenterology, vol.100, issue.6, pp.1691-1700, 1991.
DOI : 10.1016/0016-5085(91)90671-7

C. Ching, S. Holmes, G. Holmes, and R. Long, Blood-Group Sialyl-Tn Antigen Is More Specific than Tn as a Tumor Marker in the Pancreas, Pancreas, vol.9, issue.6, pp.698-702, 1994.
DOI : 10.1097/00006676-199411000-00004

Y. Cao, P. Stosiek, G. Springer, and K. U. , Thomsen-Friedenreich-related carbohydrate antigens in normal adult human tissues: a systematic and comparative study, Histochemistry and Cell Biology, vol.213, issue.Suppl 27, pp.197-207, 1996.
DOI : 10.1007/BF02484401

T. Kawaguchi, H. Takazawa, S. Imai, J. Morimoto, T. Watanabe et al., Expression of Vicia villosa agglutinin (VVA)-binding glycoprotein in primary breast cancer cells in relation to lymphatic metastasis: is atypical MUC1 bearing Tn antigen a receptor of VVA?, Breast Cancer Research and Treatment, vol.279, issue.suppl 1, pp.31-43, 2006.
DOI : 10.1007/s10549-005-9115-6

A. Medeiros, S. Bianchi, J. Calvete, H. Balter, S. Bay et al., Biochemical and functional characterization of the Tn-specific lectin from Salvia sclarea seeds, European Journal of Biochemistry, vol.272, issue.5, pp.1434-1440, 2000.
DOI : 10.1046/j.1432-1327.2000.01141.x

URL : https://hal.archives-ouvertes.fr/pasteur-00167049

E. Osinaga, S. Bay, D. Tello, A. Babino, O. Pritsch et al., Analysis of the fine specificity of Tn-binding proteins using synthetic glycopeptide epitopes and a biosensor based on surface plasmon resonance spectroscopy, FEBS Letters, vol.412, issue.1, pp.24-28, 2000.
DOI : 10.1016/S0014-5793(00)01248-5

URL : https://hal.archives-ouvertes.fr/pasteur-00166863

H. Nakada, M. Inoue, Y. Numata, N. Tanaka, I. Funakoshi et al., Epitopic structure of Tn glycophorin A for an anti-Tn antibody (MLS 128)., Proceedings of the National Academy of Sciences, vol.90, issue.6, pp.2495-2499, 1993.
DOI : 10.1073/pnas.90.6.2495

C. Reis, T. Sorensen, U. Mandel, L. David, E. Mirgorodskaya et al., Development and characterization of an antibody directed to an alpha- N-acetyl-D-galactosamine glycosylated MUC2 peptide, Glycoconjugate Journal, vol.15, issue.1, pp.51-62, 1998.
DOI : 10.1023/A:1006939432665

S. Bay, R. Lo-man, E. Osinaga, H. Nakada, C. Leclerc et al., Preparation of a multiple antigen glycopeptide (MAG) carrying the Tn antigen. A possible approach to a synthetic carbohydrate vaccine, The Journal of Peptide Research, vol.25, issue.6, pp.620-625, 1997.
DOI : 10.1111/j.1399-3011.1997.tb01171.x

URL : https://hal.archives-ouvertes.fr/pasteur-00166859

R. Lo-man, S. Bay, S. Vichier-guerre, E. Deriaud, D. Cantacuzene et al., A fully synthetic immunogen carrying a carcinoma-associated carbohydrate for active specific immunotherapy, Cancer Res, vol.59, pp.1520-1524, 1999.
URL : https://hal.archives-ouvertes.fr/pasteur-00166858

R. Lo-man, S. Vichier-guerre, S. Bay, E. Deriaud, D. Cantacuzene et al., Anti-Tumor Immunity Provided by a Synthetic Multiple Antigenic Glycopeptide Displaying a Tri-Tn Glycotope, The Journal of Immunology, vol.166, issue.4, pp.2849-2854, 2001.
DOI : 10.4049/jimmunol.166.4.2849

URL : https://hal.archives-ouvertes.fr/pasteur-00166855

G. Pancino, E. Osinaga, W. Vorauher, A. Kakouche, D. Mistro et al., Production of a Monoclonal Antibody as Immunohistochemical Marker on Paraffin Embedded Tissues Using a New Immunization Method, Hybridoma, vol.9, issue.4, pp.389-395, 1990.
DOI : 10.1089/hyb.1990.9.389

S. Vichier-guerre, R. Lo-man, S. Bay, E. Deriaud, H. Nakada et al., Short synthetic glycopeptides successfully induce antibody responses to carcinoma-associated Tn antigen, Journal of Peptide Research, vol.9, issue.2, 2000.
DOI : 10.1023/A:1006939432665

URL : https://hal.archives-ouvertes.fr/pasteur-00166856

J. Kononen, L. Bubendorf, A. Kallioniemi, M. Bärlund, P. Schraml et al., Tissue microarrays for high-throughput molecular profiling of tumor specimens, Nature Medicine, vol.54, issue.7, pp.844-84710, 1038.
DOI : 10.1023/A:1005769925670

R. Camp, L. Charette, and D. Rimm, Validation of Tissue Microarray Technology in Breast Carcinoma, Laboratory Investigation, vol.59, issue.12, pp.1943-1949, 2000.
DOI : 10.1093/jnci/92.11.937

Q. Li, M. Anver, D. Butcher, and J. Gildersleeve, Resolving conflicting data on expression of the Tn antigen and implications for clinical trials with cancer vaccines, Molecular Cancer Therapeutics, vol.8, issue.4, pp.971-979, 2009.
DOI : 10.1158/1535-7163.MCT-08-0934

M. Reddish, L. Jackson, R. Koganty, D. Qiu, W. Hong et al., Specificities of anti-sialyl-Tn and anti-Tn monoclonal antibodies generated using novel clustered synthetic glycopeptide epitopes, Glycoconjugate Journal, vol.14, issue.5, pp.549-560, 1997.
DOI : 10.1023/A:1018576224062

F. Corzana, J. Busto, G. Jiménez-osés, M. García-de-luis, J. Asensio et al., Serine versus Threonine Glycosylation:?? The Methyl Group Causes a Drastic Alteration on the Carbohydrate Orientation and on the Surrounding Water Shell, Journal of the American Chemical Society, vol.129, issue.30, pp.9458-9467, 1021.
DOI : 10.1021/ja072181b

F. Corzana, J. Busto, M. García-de-luis, J. Jiménez-barbero, A. Avenoza et al., The Nature and Sequence of the Amino Acid Aglycone Strongly Modulates the Conformation and Dynamics Effects of Tn Antigen's Clusters, Chemistry - A European Journal, vol.115, issue.15, pp.3863-3874, 2009.
DOI : 10.1002/chem.200801777

Y. Tachibana, G. Fletcher, N. Fujitani, S. Tsuda, K. Monde et al., Antifreeze Glycoproteins: Elucidation of the Structural Motifs That Are Essential for Antifreeze Activity, Angewandte Chemie International Edition, vol.43, issue.7, pp.856-862, 2004.
DOI : 10.1002/anie.200353110

O. Blixt, O. Lavrova, D. Mazurov, E. Cló, S. Kracun et al., Analysis of Tn antigenicity with a panel of new IgM and IgG1 monoclonal antibodies raised against leukemic cells, Glycobiology, vol.22, issue.4, pp.529-542, 2012.
DOI : 10.1093/glycob/cwr178

T. Christlet, T. Veluraja, and K. , Database Analysis of O-Glycosylation Sites in Proteins, Biophysical Journal, vol.80, issue.2, pp.952-960, 2001.
DOI : 10.1016/S0006-3495(01)76074-2

A. Elhammer, F. Kézdy, and A. Kurosaka, The acceptor specificity of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, Glycoconjugate Journal, vol.16, issue.2, pp.171-180, 1999.
DOI : 10.1023/A:1026465232149

V. Mensdorff-pouilly, S. Petrakou, E. Kenemans, P. Van-uffelen, K. Verstraeten et al., Reactivity of natural and induced human antibodies to MUC1 mucin with MUC1 peptides and N-acetylgalactosamine (GalNAc) peptides, 5\702:AID-IJC16[3.0.CO, pp.702-71210, 2000.

E. Smorodin, O. Kurtenkov, B. Sergeyev, K. Kodar, V. Chuzmarov et al., Postoperative change of anti-Thomsen-Friedenreich and Tn IgG level: The follow-up study of gastrointestinal cancer patients, World Journal of Gastroenterology, vol.14, issue.27, pp.4352-4358, 2008.
DOI : 10.3748/wjg.14.4352

O. Oyelaran, Q. Li, D. Farnsworth, and J. Gildersleeve, Microarrays with Varying Carbohydrate Density Reveal Distinct Subpopulations of Serum Antibodies, Journal of Proteome Research, vol.8, issue.7, pp.3529-3538, 2009.
DOI : 10.1021/pr9002245

S. Matsukita, M. Nomoto, S. Kitajima, S. Tanaka, M. Goto et al., Expression of mucins (MUC1, MUC2, MUC5AC and MUC6) in mucinous carcinoma of the breast: comparison with invasive ductal carcinoma, Histopathology, vol.43, issue.1, pp.26-36, 2003.
DOI : 10.1006/geno.1996.0637

M. Pereira, A. Dias, C. Reis, and F. Schmitt, Immunohistochemical study of the expression of MUC5AC and MUC6 in breast carcinomas and adjacent breast tissues, Journal of Clinical Pathology, vol.54, issue.3, pp.210-213, 2001.
DOI : 10.1136/jcp.54.3.210

N. Berois, M. Varangot, C. Sóñora, L. Zarantonelli, C. Pressa et al., Detection of bone marrow-disseminated breast cancer cells using an RT-PCR assay of MUC5B mRNA, International Journal of Cancer, vol.251, issue.4, pp.550-555, 2003.
DOI : 10.1002/ijc.10853

C. De-bolòs, M. Gumà, C. Barranco, M. Garrido, Y. Kim et al., MUC6 expression in breast tissues and cultured cells: Abnormal expression in tumors and regulation by steroid hormones, 2\193:AID-IJC4[3.0.CO, pp.193-199, 1998.
DOI : 10.1002/(SICI)1097-0215(19980717)77:2<193::AID-IJC4>3.0.CO;2-L

J. Byrd and R. Bresalier, Mucins and mucin binding proteins in colorectal cancer, Cancer and Metastasis Reviews, vol.23, issue.1/2, pp.77-99, 2004.
DOI : 10.1023/A:1025815113599

C. Welinder, B. Baldetorp, C. Borrebaeck, B. Fredlund, and B. Jansson, A new murine IgG1 anti-Tn monoclonal antibody with in vivo anti-tumor activity, Glycobiology, vol.21, issue.8, pp.1097-1107, 2011.
DOI : 10.1093/glycob/cwr048

H. Ando, T. Matsushita, M. Wakitani, T. Sato, S. Kodama-nishida et al., Mouse-Human Chimeric Anti-Tn IgG1 Induced Anti-tumor Activity against Jurkat Cells in Vitro and in Vivo, Biological & Pharmaceutical Bulletin, vol.31, issue.9, pp.1739-1744, 2008.
DOI : 10.1248/bpb.31.1739

P. Hubert, A. Heitzmann, S. Viel, A. Nicolas, X. Sastre-garau et al., Antibody-Dependent Cell Cytotoxicity Synapses Form in Mice during Tumor-Specific Antibody Immunotherapy, Cancer Research, vol.71, issue.15, pp.5134-5143, 2011.
DOI : 10.1158/0008-5472.CAN-10-4222

URL : https://hal.archives-ouvertes.fr/pasteur-00685062

K. Lavrsen, C. Madsen, M. Rasch, A. Woetmann, N. Odum et al., Aberrantly glycosylated MUC1 is expressed on the surface of breast cancer cells and a target for antibody-dependent cell-mediated cytotoxicity, Glycoconjugate Journal, vol.28, issue.28, pp.10-1007, 2012.
DOI : 10.1007/s10719-012-9437-7

C. Danussi, A. Coslovi, C. Campa, M. Mucignat, P. Spessotto et al., A newly generated functional antibody identifies Tn antigen as a novel determinant in the cancer cell-lymphatic endothelium interaction, Glycobiology, vol.19, issue.10, pp.1056-1067, 2009.
DOI : 10.1093/glycob/cwp085

N. Morita, Y. Yajima, H. Asanuma, H. Nakada, and Y. Fujita-yamaguchi, Inhibition of cancer cell growth by anti-Tn monoclonal antibody MLS128, Biosci Trends, vol.3, pp.32-37, 2009.