Skip to Main content Skip to Navigation
Journal articles

Death and the retrovirus.

Abstract : A flurry of new papers has shown that HIV reverse transcription is vulnerable to G-->A hypermutation. Apparently, cytidine bases in nascent DNA synthesis are lethally edited by the host cell molecule apolipoprotein B editing complex protein (APOBEC) 3G. This death mechanism is circumvented by the HIV viral infectivity factor protein, which prevents APOBEC3G from entering the virion.
Document type :
Journal articles
Complete list of metadata

Cited literature [47 references]  Display  Hide  Download

https://hal-riip.archives-ouvertes.fr/pasteur-00850260
Contributor : Peter Sommer Connect in order to contact the contributor
Submitted on : Tuesday, August 6, 2013 - 5:51:49 AM
Last modification on : Thursday, January 13, 2022 - 6:32:02 PM
Long-term archiving on: : Wednesday, April 5, 2017 - 7:28:31 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Jean Pierre Vartanian, Peter Sommer, Simon Wain-Hobson. Death and the retrovirus.. Trends in Molecular Medicine, Elsevier, 2003, 9 (10), pp.409-13. ⟨10.1016/j.molmed.2003.08.008⟩. ⟨pasteur-00850260⟩

Share

Metrics

Les métriques sont temporairement indisponibles