Death and the retrovirus.

Jean Pierre Vartanian (1) , Peter Sommer (1) , Simon Wain-Hobson (1)

1 Rétrovirologie Moléculaire

A flurry of new papers has shown that HIV reverse transcription is vulnerable to G-->A hypermutation. Apparently, cytidine bases in nascent DNA synthesis are lethally edited by the host cell molecule apolipoprotein B editing complex protein (APOBEC) 3G. This death mechanism is circumvented by the HIV viral infectivity factor protein, which prevents APOBEC3G from entering the virion.

Domaines: Virologie

Jean Pierre Vartanian, Peter Sommer, Simon Wain-Hobson. Death and the retrovirus.. Trends in Molecular Medicine, 2003, 9 (10), pp.409-13. ⟨10.1016/j.molmed.2003.08.008⟩. ⟨pasteur-00850260⟩