Consanguinity, endogamy, and genetic disorders in Tunisia.

Nizar Ben Halim (1) , Nissaf Ben Alaya Bouafif (1) , Lilia Romdhane (1) , Rym Kefi Ben Atig (1) , Ibtissem Chouchane (2) , Yosra Bouyacoub (1) , Imen Arfa (1) , Wafa Cherif (1) , Sonia Nouira (1) , Faten Talmoudi (1) , Khaled Lasram (1) , Sana Hsouna (1) , Welid Ghazouani (1) , Hela Azaiez (1) , Leila El Matri (2) , Abdelmajid Abid (1, 3) , Neji Tebib (4) , Marie-Françoise Ben Dridi (4) , Salem Kachboura (5) , Ahlem Amouri (1) , Mourad Mokni (6) , Saida Ben Arab (7) , Koussay Dellagi (8) , Sonia Abdelhak (1)

1 Institut Pasteur de Tunis
2 Oculogenetics Research Unit
3 National Institute of Nutrition
4 Inherited Metabolic Diseases Unit, Pediatric Department
5 Research Unit UR 09/04, Cardiology Department
6 Research Unit on Hereditary Keratinization Disorders, Department of Dermatology
7 Unity of Genetic and Molecular Epidemiology, Faculty of Medicine
8 LVGM - Laboratoire d'Immunopathologie, Vaccinologie et Génétique Moléculaire

Consanguinity refers to marriages between individuals who share at least one common ancestor. In clinical genetics, a consanguineous marriage is defined as a union between two individuals who are related as second cousins or closer, with the inbreeding coefficient (F) equal or higher than 0.0156 (Bittles2001). However, reports on consanguinity rates may sometimes include marriages between third cousins or more distantly related individuals (Hamamy2011). It is estimate that more than 690 million people in the world are consan- guineous (Bittles and Black 2010 ). Middle East, Northern Africa, and South Asia are regions that have historically and culturally had a high rate of consanguineous unions (Al- Awadi et al. 1985; Al-Gazali et al.1997; Jaber et al.1997;Bittles et al.2002; Bener and Alali2006). Recent studieshave shown that 20 % to 50 % of marriages in Arab countries are between relatives (Tadmouri et al. 2009;Bittles2011; Hamamy et al.2011). The rate was 68 % inEgypt (Mokhtar and Abdel-Fattah2001), 51-58 % in Jordan

Domains: Life Sciences [q-bio]

Nizar Ben Halim, Nissaf Ben Alaya Bouafif, Lilia Romdhane, Rym Kefi Ben Atig, Ibtissem Chouchane, et al.. Consanguinity, endogamy, and genetic disorders in Tunisia.. Journal of Community Genetics, 2013, 4 (2), pp.273-84. ⟨10.1007/s12687-012-0128-7⟩. ⟨pasteur-00859212⟩