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Journal articles
Consanguinity, endogamy, and genetic disorders in Tunisia.
Nizar Ben Halim
1, *
Nissaf Ben Alaya Bouafif
1
Lilia Romdhane
1
Rym Kefi Ben Atig
1
Ibtissem Chouchane
2
Yosra Bouyacoub
1
Imen Arfa
1
Wafa Cherif
1
Sonia Nouira
1
Faten Talmoudi
1
Khaled Lasram
1
Sana Hsouna
1
Welid Ghazouani
1
Hela Azaiez
1
Leila El Matri
2
Abdelmajid Abid
1, 3
Neji Tebib
4
Marie-Françoise Ben Dridi
4
Salem Kachboura
5
Ahlem Amouri
1
Mourad Mokni
6
Saida Ben Arab
7
Koussay Dellagi
8
Sonia Abdelhak
1, *
*
Corresponding author
Nizar Ben Halim 1
Correspondent author
Nissaf Ben Alaya Bouafif 1
Author
Lilia Romdhane 1
Author
Rym Kefi Ben Atig 1
Author
Neji Tebib 4
Author
Marie-Françoise Ben Dridi 4
Author
Salem Kachboura 5
Author
Ahlem Amouri 1
Author
Mourad Mokni 6
Author
Saida Ben Arab 7
Author
Koussay Dellagi 8
Author
Sonia Abdelhak 1
Correspondent author
1
Institut Pasteur de Tunis (13, place Pasteur, BP 74, 1002 Tunis Belvédère - Tunisia)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
2
Oculogenetics Research Unit (Boulevard 9 Avril, Bab Saadoun, 1006, Tunis - Tunisia)
- Hedi Rais Institute of Ophthalmology (France)
3
National Institute of Nutrition (Rue Djebel Lakhdar, Bab Saadoun, 1007, Tunis - Tunisia)
- National Institute of Nutrition (France)
4
Inherited Metabolic Diseases Unit, Pediatric Department (Eljabbari, 1007, Tunis - Tunisia)
- Hôpital La Rabta [Tunis] (La Rabta Jebbari 1007 Tunis - Tunisia)
5
Research Unit UR 09/04, Cardiology Department (Rue Abderrahmen Mami, 2080, Ariana - Tunisia)
- Abderahman Mami Hospital (France)
6
Research Unit on Hereditary Keratinization Disorders, Department of Dermatology (Eljabbari, 1007, Tunis - Tunisia)
- Hôpital La Rabta [Tunis] (La Rabta Jebbari 1007 Tunis - Tunisia)
7
Unity of Genetic and Molecular Epidemiology, Faculty of Medicine (15 Rue Djebel Akhdhar, Bab Saâdoun, 1007, Tunis, Tunisia - Tunisia)
- Faculty of Medicine of Tunis (France)
8
LVGM - Laboratoire d'Immunopathologie, Vaccinologie et Génétique Moléculaire (Tunis - Tunisia)
- Institut Pasteur de Tunis (13, place Pasteur, BP 74, 1002 Tunis Belvédère - Tunisia)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
Abstract : Consanguinity refers to marriages between individuals who share at least one common ancestor. In clinical genetics, a consanguineous marriage is defined as a union between two individuals who are related as second cousins or closer, with the inbreeding coefficient (F) equal or higher than 0.0156 (Bittles2001). However, reports on consanguinity rates may sometimes include marriages between third cousins or more distantly related individuals (Hamamy2011). It is estimate that more than 690 million people in the world are consan- guineous (Bittles and Black 2010 ). Middle East, Northern Africa, and South Asia are regions that have historically and culturally had a high rate of consanguineous unions (Al- Awadi et al. 1985; Al-Gazali et al.1997; Jaber et al.1997;Bittles et al.2002; Bener and Alali2006). Recent studieshave shown that 20 % to 50 % of marriages in Arab countries are between relatives (Tadmouri et al. 2009;Bittles2011; Hamamy et al.2011). The rate was 68 % inEgypt (Mokhtar and Abdel-Fattah2001), 51-58 % in Jordan
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https://hal-riip.archives-ouvertes.fr/pasteur-00859212
Contributor : Institut Pasteur Tunis Connect in order to contact the contributor
Submitted on : Friday, September 6, 2013 - 4:26:42 PM
Last modification on : Monday, September 2, 2019 - 11:02:04 AM
Long-term archiving on: : Thursday, April 6, 2017 - 4:20:15 PM
Contributor : Institut Pasteur Tunis Connect in order to contact the contributor
Submitted on : Friday, September 6, 2013 - 4:26:42 PM
Last modification on : Monday, September 2, 2019 - 11:02:04 AM
Long-term archiving on: : Thursday, April 6, 2017 - 4:20:15 PM
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- HAL Id : pasteur-00859212, version 1
- DOI : 10.1007/s12687-012-0128-7
- PUBMED : 23208456
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Nizar Ben Halim, Nissaf Ben Alaya Bouafif, Lilia Romdhane, Rym Kefi Ben Atig, Ibtissem Chouchane, et al.. Consanguinity, endogamy, and genetic disorders in Tunisia.. Journal of Community Genetics, Springer, 2013, 4 (2), pp.273-84. ⟨10.1007/s12687-012-0128-7⟩. ⟨pasteur-00859212⟩
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