Cellular and humoral responses to Leishmania major virulence factors in healed cutaneous leishmaniasis and Mediterranean visceral leishmaniasis patients.

Inès Lakhal-Naouar (1) , Thouraya Boussoffara (1) , Amel Meddeb-Garnaoui (1) , Yosser Ben Achour-Chenik (1) , Hechmi Louzir (1, 2) , Mehdi Chenik (1)

1 LVGM - Laboratoire d'Immunopathologie, Vaccinologie et Génétique Moléculaire
2 Institut Pasteur de Tunis

Cellular and humoral immune responses of healed cutaneous leishmaniasis and Mediterranean visceral leishmaniasis patients were evaluated against results for Leishmania major virulence proteins L. major protein disulfide isomerase (LmPDI) and mitogen-activated protein kinase kinase (MAPKK). Only MAPKK induces significant peripheral blood mononuclear cell proliferation with gamma interferon production as well as antibody responses. Thus, MAPKK may be of interest in Leishmania vaccination and serodiagnosis.

Domaines: Sciences du Vivant [q-bio]

Inès Lakhal-Naouar, Thouraya Boussoffara, Amel Meddeb-Garnaoui, Yosser Ben Achour-Chenik, Hechmi Louzir, et al.. Cellular and humoral responses to Leishmania major virulence factors in healed cutaneous leishmaniasis and Mediterranean visceral leishmaniasis patients.. Clinical and Vaccine Immunology, 2009, 16 (6), pp.956-8. ⟨10.1128/CVI.00023-09⟩. ⟨pasteur-00859426⟩