The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: A NTM-NET collaborative study.

W. Hoefsloot , Jakko van Ingen (1) , Claire Andréjak , K. Angeby (2) , R. Bauriaud (3) , P. Bemer (4, 5) , N. Beylis , M. J. Boeree , J. Cacho , V. Chihota , E. Chimara , G. Churchyard , R. Cias , R. Dasa , C. L. Daley , P. N. R. Dekhuijzen , D. Domingo (6) , F. Drobniewski , J. Esteban (7) , M. Fauville-Dufaux (8) , D. B. Folkvardsen , N. Gibbons , E. Gómez-Mampaso , R. Gonzalez (9) , H. Hoffmann , P. R. Hsueh , A. Indra , T. Jagielski (10) , F. Jamieson , M. Jankovic , E. Jong , J. Keane , W. J. Koh , B. Lange , S. Leao , R. Macedo , T. Mannsåker , T. K. Marras , J. Maugein , H. J. Milburn , T. Mlinkó , N. Morcillo , K. Morimoto , D. Papaventsis , E. Palenque , M. Paez-Peña , C. Piersimoni , M. Polanová , N. Rastogi (11) , E. Richter , M. J. Ruiz-Serrano , A. Silva , M. P. da Silva , H. Simsek , D. van Soolingen , N. Szabó , R. Thomson , M T Tórtola Fernandez , E. Tortoli (12) , S. E. Totten , G. Tyrrell , T. Vasankari , M. Villar (13) , R. Walkiewicz , K. Winthrop , D. Wagner

1 Dept of Medical Microbiology
2 Departement of Clinical Microbiology
3 Laboratoire Central de Microbiologie
4 Service de Bactériologie-Hygiène
5 Department of Microbiology
6 Lab. Fisica Aplicada
7 Department of Clinical Microbiology
8 CNR - Centre national de Référence et Laboratoire Tuberculose et Mycobactéries = National Reference Centre of Tuberculosis and Mycobacteria [Brussels]
9 LPI - Laboratoire de Physiologie des Invertébrés
10 Department of Applied Microbiology [Warsaw]
11 Institut Pasteur de la Guadeloupe
12 Centro Regionale di Riferimento per i Micobatteri
13 General Directorate of Health

A significant knowledge gap exists concerning the geographical distribution of nontuberculous mycobacteria (NTM) isolation worldwide.To provide a snapshot of NTM species distribution, global partners in the NTM-NET framework (www.ntm-net.org), a branch of TBNET, provided identification results of the total number of patients in 2008 in whom NTM were isolated from pulmonary samples. From these data, we visualized the relative distribution of the different NTM found per continent and country.We received species identification data for 20182 patients, from 62 laboratories in 30 countries across six continents. Ninety-one different NTM species were isolated. Mycobacterium avium complex (MAC) bacteria predominated in most countries, followed by M. gordonae and M. xenopi. Important differences in geographical distribution of MAC species as well as M. xenopi, M. kansasii, and rapid growing mycobacteria were observed.This snapshot demonstrates that the species distribution among NTM isolates from pulmonary specimens in the year 2008 differed by continent and differs by countries within these continents. These differences in species distribution may partly determine the frequency and manifestations of pulmonary NTM disease in each geographical location.

Keywords: Mycobacterium; Nontuberculous mycobacteria; Atypical mycobacteria; Geographic diversity; Pulmonary infections; Respiratory infections; NTM; Worldwide distribution; Mycobacterium avium; Mycobacterium intracellulare; Mycobacterium gordonae; Mycobacterium xenopi; Mycobacterium kansasii; Mycobacterium abscessus; Mycobacterium fortuitum; Mycobacterium malmoense; Mycobacterium simiae; Mycobacterium scrofulaceum; Mycobacterium lentiflavum; Mycobacterium smegmatis; Mycobacterium interjectum; Mycobacterium bohemicum

Domains: Bacteriology

W. Hoefsloot, Jakko van Ingen, Claire Andréjak, K. Angeby, R. Bauriaud, et al.. The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: A NTM-NET collaborative study.. European Respiratory Journal, 2013, 42 (6), pp.1604-1613. ⟨10.1183/09031936.00149212⟩. ⟨pasteur-00870727⟩