Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients.

Meriem Ben-Ali (1) , Mohamed-Ridha Barbouche (1) , Soufia Bousnina (2) , Abdellatif Chabbou (2) , Koussay Dellagi (1)

1 LVGM - Laboratoire d'Immunopathologie, Vaccinologie et Génétique Moléculaire
2 Service de Pneumo-phtysiologie

Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacteria. Herein, we report that the frequency of a human TLR2 Arg677Trp polymorphism (C2029T nucleotide substitution) in tuberculosis patients in Tunisia is significantly higher than in healthy controls (P < 0.0001). This finding suggests that this polymorphism could be a risk factor for tuberculosis.

Domaines: Sciences du Vivant [q-bio]

Meriem Ben-Ali, Mohamed-Ridha Barbouche, Soufia Bousnina, Abdellatif Chabbou, Koussay Dellagi. Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients.. Clinical and Diagnostic Laboratory Immunology, 2004, 11 (3), pp.625-6. ⟨10.1128/CDLI.11.3.625-626.2004⟩. ⟨pasteur-00875161⟩