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Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients.

Meriem Ben-Ali 1 Mohamed-Ridha Barbouche 1 Soufia Bousnina 2 Abdellatif Chabbou 2 Koussay Dellagi 1
1 LVGM - Laboratoire d'Immunopathologie, Vaccinologie et Génétique Moléculaire
2 Service de Pneumo-phtysiologie
Abstract : Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacteria. Herein, we report that the frequency of a human TLR2 Arg677Trp polymorphism (C2029T nucleotide substitution) in tuberculosis patients in Tunisia is significantly higher than in healthy controls (P < 0.0001). This finding suggests that this polymorphism could be a risk factor for tuberculosis.
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https://hal-riip.archives-ouvertes.fr/pasteur-00875161
Contributor : Institut Pasteur Tunis <>
Submitted on : Monday, October 21, 2013 - 12:19:10 PM
Last modification on : Monday, October 8, 2018 - 5:44:07 PM

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Meriem Ben-Ali, Mohamed-Ridha Barbouche, Soufia Bousnina, Abdellatif Chabbou, Koussay Dellagi. Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients.. Clinical and Diagnostic Laboratory Immunology, American Society for Microbiology, 2004, 11 (3), pp.625-6. ⟨10.1128/CDLI.11.3.625-626.2004⟩. ⟨pasteur-00875161⟩

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