E. Who and . Committee, Control of the leishmaniasis, WHO Tech Rep Ser, vol.793, pp.1-158, 1990.

B. Ismail, R. Gradoni, L. Gramiccia, M. Bettini, S. et al., Epidemic cutaneous leishmaniasis in Tunisia: biochemical characterization of parasites, Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.80, issue.4, pp.669-70, 1986.
DOI : 10.1016/0035-9203(86)90175-6

B. Salah, A. Zakraoui, H. Zatour, and A. , A randomized placebocontrolled trial in Tunisia of treating cutaneous leishmaniasis with paramomycin ointment, Am J Trop Med Hyg, vol.53, pp.162-168, 1995.

P. Manson-bahr and . Diagnosis, The Leishmaniasis in biology and medicine, pp.703-732, 1987.

R. Alvarado, C. Enk, K. Jaber, L. Schur, and S. Frankenburg, Delayed-type hypersensitivity and lymphocyte proliferation in response to Leishmania major infection in a group of children in Jericho, Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.83, issue.2, pp.189-92, 1989.
DOI : 10.1016/0035-9203(89)90637-8

K. Weigle, L. Valderama, and A. Arias, Leishmanin skin test standardization and evaluation of safety, dose, storage, longevity of reaction, and sensitization, Am J Trop Med Hyg, vol.44, pp.260-71, 1991.

K. Weigle, L. Valderama, and A. Arias, Epidemiology of Cutaneous Leishmaniasis in Colombia: A Longitudinal Study of the Natural History, Prevalence, and Incidence of Infection and Clinical Manifestations, Journal of Infectious Diseases, vol.168, issue.3, pp.699-708, 1993.
DOI : 10.1093/infdis/168.3.699

S. Guirges, Natural and experimental re-infection of man with Oriental sore, Annals of Tropical Medicine & Parasitology, vol.29, issue.2, pp.197-205, 1971.
DOI : 10.1017/S0031182000002730

C. Davies, E. Llanos-cuentas, and S. Pyke, Cutaneous leishmaniasis in the Peruvian Andes: an epidemiological study of infection and immunity, Epidemiology and Infection, vol.168, issue.02, pp.297-318, 1995.
DOI : 10.1016/0035-9203(89)90496-3

S. Reiner and R. Locksley, The Regulation of Immunity to Leishmania Major, Annual Review of Immunology, vol.13, issue.1, pp.151-77, 1995.
DOI : 10.1146/annurev.iy.13.040195.001055

J. Passwell, R. Shor, H. Tran, J. Sholiam, and C. Jaffe, Antigen-stimulated lymphokines from patients with cutaneous leishmaniasis induce monocyte killing of Leishmania major cellular amastigotes, J Immunol, vol.139, pp.4208-4220, 1987.

H. Murray, B. Rubin, and C. Rothermel, Killing of intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocytes. Evidence that interferon-gamma is the activating lymphokine., Journal of Clinical Investigation, vol.72, issue.4, pp.1506-1518, 1983.
DOI : 10.1172/JCI111107

S. Reed and P. Scott, T-cell and cytokine responses in leishmaniasis, Current Opinion in Immunology, vol.5, issue.4, pp.524-555, 1993.
DOI : 10.1016/0952-7915(93)90033-O

E. Carvalho, W. Johnson, and E. Barreto, Cell mediated immunity in American cutaneous and mucosal leishmaniasis, J Immunol, vol.135, pp.4144-4152, 1985.

P. Melby, F. Neva, and D. Sacks, Profile of human T cell response to leishmanial antigens. Analysis by immunoblotting., Journal of Clinical Investigation, vol.83, issue.6, pp.1868-75, 1989.
DOI : 10.1172/JCI114093

C. Pirmez, C. Cooper, M. Paes-oliveira, A. Schubach, V. Torigian et al., Immunologic responsiveness in American cutaneous leishmaniasis lesions, J Immunol, vol.145, pp.3100-3104, 1990.

M. Kemp, A. Hey, and A. Kurtzhals, Dichotomy of the human T cell response to Leishmania antigens. I. Th1-like response to Leishmania major promastigote antigens in individuals recovered from cutaneous leishmaniasis, Clinical & Experimental Immunology, vol.96, issue.3, pp.410-415, 1994.
DOI : 10.1111/j.1365-2249.1994.tb06043.x

S. Rafati, S. Couty-jouve, and M. Alimhammadian, Biochemical analysis and immunogenicity of Leishmania major amastigote fractions in cutaneous leishmaniasis, Clinical & Experimental Immunology, vol.62, issue.2, pp.203-214, 1997.
DOI : 10.1111/j.1365-2249.1997.tb08318.x

J. Sokal, Measurement of Delayed Skin-Test Responses, New England Journal of Medicine, vol.293, issue.10, pp.501-503, 1975.
DOI : 10.1056/NEJM197509042931013

P. Scott, E. Pearce, P. Natovitz, and A. Sher, Vaccination against cutaneous leishmaniasis in murine model II. Immunological properties of protective and non protective subfractions of a soluble promastigotes extract, J Immunol, vol.139, pp.3118-3143, 1987.

R. Badaro, T. Jones, and R. Lorenço, A Prospective Study of Visceral Leishmaniasis in an Endemic Area of Brazil, Journal of Infectious Diseases, vol.154, issue.4, pp.639-688, 1986.
DOI : 10.1093/infdis/154.4.639

E. Zijlstra and A. El-hassen, Leishmanin and tuberculin sensitivity in leishmaniasis in the Sudan, with special reference to kala-azar, Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.87, issue.4, pp.425-432, 1993.
DOI : 10.1016/0035-9203(93)90024-K

P. Marty, A. Lelievre, J. Quaranta, A. Rahal, M. Gari-toussaint et al., Use of the leishmanin skin test and Western blot analysis for epidemiological studies in visceral leishmaniasis areas: experience in a highly endemic focus in Alpes-Maritimes (France), Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.88, issue.6, pp.658-667, 1994.
DOI : 10.1016/0035-9203(94)90214-3

A. Kadaro, H. Ghalib, and M. Ali, Prevalence of cutaneous leishmaniasis along the Nile river north of Khartoum (Sudan) in the aftermath of an epidemic in 1985, Am J Trop Med Hyg, vol.48, pp.44-49, 1993.

N. Jumaian, S. Kamhawi, M. Halalsheh, and S. Abdel-hafez, Short report: outbreak of cutaneous leishmaniasis in a non immune population of soldiers in Wadi Araba, Jordan, Am J Trop Med Hyg, vol.58, pp.160-162, 1998.

T. Mosmann and K. Moore, The role of IL-10 in crossregulation of TH1 and TH2 responses, Immunology Today, vol.12, issue.3, pp.49-54, 1991.
DOI : 10.1016/S0167-5699(05)80015-5

R. De-waal-malefyt, J. Abrams, B. Bennett, C. Figdor, and J. De-vries, Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes, Journal of Experimental Medicine, vol.174, issue.5, pp.1209-1229, 1991.
DOI : 10.1084/jem.174.5.1209

D. Fiorentino, A. Zlotnik, and P. Vieira, IL-10 acts on antigenpresenting cell to inhibit cytokine production by Th1 cells, J Immunol, vol.146, pp.3444-51, 1991.

D. Prete, G. , D. Carli, M. Almerigogna, F. Guidizi et al., Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production, J Immunol, vol.150, pp.353-60, 1993.

C. Karp, S. El-safi, and T. Wynn, In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma., Journal of Clinical Investigation, vol.91, issue.4, pp.1644-1652, 1993.
DOI : 10.1172/JCI116372

H. Ghalib, M. Pitivezam, and Y. Skeiky, Interleukin 10 production correlates with pathology in human Leishmania donovani infections., Journal of Clinical Investigation, vol.92, issue.1, pp.324-333, 1993.
DOI : 10.1172/JCI116570

P. Melby, F. Andrade-narvaez, B. Damell, G. Valencia-pacheco, V. Tryon et al., Increased expression of proinflammatory cytokines in chronic lesions of humans cutaneous leishmaniasis, Infect Immun, vol.62, pp.837-879, 1994.