Real-time PCR assay for rapid detection of epidemiologically and clinically significant Mycobacterium tuberculosis Beijing genotype.

Abstract : : Mycobacterium tuberculosis Beijing genotype strains are rapidly disseminating, frequently hypervirulent and multidrug resistant. Here, we describe a method of their rapid detection by real-time PCR targeting the specific IS6110 insertion in the dnaA-dnaN genome region. The method was evaluated with both geographically and genetically diverse collection representing Beijing genotype-endemic and epidemic areas in East Asia and former Soviet Union i.e., major foci of its global propagation, and with clinical specimens.
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Journal articles
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Submitted on : Friday, February 14, 2014 - 5:09:23 PM
Last modification on : Monday, October 8, 2018 - 5:44:06 PM

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Igor Mokrousov, Anna Vyazovaya, Viacheslav Zhuravlev, Tatiana Otten, Julie Millet, et al.. Real-time PCR assay for rapid detection of epidemiologically and clinically significant Mycobacterium tuberculosis Beijing genotype.. Journal of Clinical Microbiology, American Society for Microbiology, 2014, epub ahead of print. ⟨10.1128/JCM.03193-13⟩. ⟨pasteur-00947146⟩

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