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Journal articles
Shedding of genes that interfere with the pathogenic lifestyle: the Shigella model.
Abstract : Pathoadaptive mutations are evolutionary events leading to the silencing of specific anti-virulence loci. This reshapes the core genome of a novel pathogen, adapts it to the host and boosts its harmful potential. A paradigmatic case is the emergence of Shigella, the causative agent of bacillary dysentery, from its innocuous Escherichia coli ancestor. Here we summarize current views on how pathoadaptation has allowed Shigella to progressively increase its virulence. In this context, modification of the polyamine pattern emerges as a crucial step towards full expression of the virulence program in Shigella.
Cited literature [56 references]
https://hal-riip.archives-ouvertes.fr/pasteur-00947763
Contributor : Istituto Pasteur Fondazione Cenci Bolognetti Connect in order to contact the contributor
Submitted on : Monday, February 17, 2014 - 1:33:19 PM
Last modification on : Wednesday, November 3, 2021 - 2:18:08 PM
Contributor : Istituto Pasteur Fondazione Cenci Bolognetti Connect in order to contact the contributor
Submitted on : Monday, February 17, 2014 - 1:33:19 PM
Last modification on : Wednesday, November 3, 2021 - 2:18:08 PM