R. Velasco, A. Zharkikh, and J. Affourtit, The genome of the domesticated apple (Malus ?? domestica Borkh.), Nature Genetics, vol.1, issue.10, pp.833-839, 2010.
DOI : 10.1086/319501

S. Reagan-shaw, D. Eggert, H. Mukhtar, and N. Ahmad, Antiproliferative Effects of Apple Peel Extract Against Cancer Cells, Nutrition and Cancer, vol.78, issue.4, pp.517-524, 2010.
DOI : 10.1016/j.talanta.2004.07.051

C. Gerhauser, Cancer Chemopreventive Potential of Apples, Apple Juice, and Apple Components, Planta Medica, vol.74, issue.13, pp.1608-1624, 2008.
DOI : 10.1055/s-0028-1088300

J. H. Boyerandr and . Liu, Applephytochemicalsandtheirhealth benefits, Nutrition Journal, vol.3, issue.1, pp.1-45, 2004.

T. K. Mcghie, S. Hudault, R. C. Lunken, and J. T. Christeller, Apple Peels, from Seven Cultivars, Have Lipase-Inhibitory Activity and Contain Numerous Ursenoic Acids As Identified by LC-ESI-QTOF-HRMS, Journal of Agricultural and Food Chemistry, vol.60, issue.1, pp.482-491, 2012.
DOI : 10.1021/jf203970j

U. Vrhovsek, A. Rigo, D. Tonon, and F. Mattivi, Quantitation of Polyphenols in Different Apple Varieties, Journal of Agricultural and Food Chemistry, vol.52, issue.21, pp.6532-6538, 2004.
DOI : 10.1021/jf049317z

P. Vanzani, M. Rossetto, and A. Rigo, Major Phytochemicals in Apple Cultivars:?? Contribution to Peroxyl Radical Trapping Efficiency, Journal of Agricultural and Food Chemistry, vol.53, issue.9, pp.3377-3382, 2005.
DOI : 10.1021/jf040482o

R. H. Liu and J. Sun, Antiproliferative Activity of Apples Is Not Due to Phenolic-Induced Hydrogen Peroxide Formation, Journal of Agricultural and Food Chemistry, vol.51, issue.6, pp.1718-1723, 2003.
DOI : 10.1021/jf026162r

M. Waldecker, T. Kautenburger, and H. Daumann, Histone-deacetylase inhibition and butyrate formation: Fecal slurry incubations with apple pectin and apple juice extracts, Nutrition, vol.24, issue.4, pp.366-374, 2008.
DOI : 10.1016/j.nut.2007.12.013

M. G. Mirisola and V. D. Longo, Conserved role of Ras-GEFs in promoting aging: from yeast to mice, Aging, vol.3, issue.4, pp.340-343, 2011.
DOI : 10.18632/aging.100320

D. Carmona-gutierrez, T. Eisenberg, S. Büttner, C. Meisinger, G. Kroemer et al., Apoptosis in yeast: triggers, pathways, subroutines, Cell Death and Differentiation, vol.6, issue.5, pp.763-773, 2010.
DOI : 10.1038/cdd.2008.150

A. Cassidy-stone, J. E. Chipuk, and E. Ingerman, Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization, Developmental Cell, vol.14, issue.2, pp.193-204, 2008.
DOI : 10.1016/j.devcel.2007.11.019

V. Palermo, C. Falcone, M. Calvani, and C. Mazzoni, Acetyl-l-carnitine protects yeast cells from apoptosis and aging and inhibits mitochondrial fission, Aging Cell, vol.13, issue.4, pp.570-579, 2010.
DOI : 10.1111/j.1474-9726.2010.00587.x

C. Mazzoni and C. Falcone, Isolation and study of KILSM4, a Kluyveromyces lactis gene homologous to the essential gene LSM4 of Saccharomyces cerevisiae, pp.1249-1256, 2001.

C. Mazzoni, P. Mancini, F. Madeo, V. Palermo, and C. Falcone, A mutant in the essential gene shows phenotypic markers of apoptosis, FEMS Yeast Research, vol.4, issue.1, pp.29-35, 2003.
DOI : 10.1016/S1567-1356(03)00151-X

C. Mazzoni, E. Herker, and V. Palermo, Yeast caspase 1 links messenger RNA stability to apoptosis in yeast, EMBO reports, vol.15, issue.11, pp.1076-1081, 1995.
DOI : 10.1126/science.283.5407.1493

A. E. Mayes, L. Verdone, P. Legrain, and J. D. Beggs, Characterization of Sm-like proteins in yeast and their association with U6 snRNA, The EMBO Journal, vol.18, issue.15, pp.4321-4331, 1999.
DOI : 10.1093/emboj/18.15.4321

C. Mazzoni, P. Mancini, and L. Verdone, A Truncated Form of KlLsm4p and the Absence of Factors Involved in mRNA Decapping Trigger Apoptosis in Yeast, Molecular Biology of the Cell, vol.14, issue.2, pp.721-729, 2003.
DOI : 10.1091/mbc.E02-05-0258

F. Chinnici, A. Bendini, A. Gaiani, and C. Riponi, Radical Scavenging Activities of Peels and Pulps from cv. Golden Delicious Apples as Related to Their Phenolic Composition, Journal of Agricultural and Food Chemistry, vol.52, issue.15, pp.4684-4689, 2004.
DOI : 10.1021/jf049770a

P. Franceschi, Y. Dong, K. Strupat, U. Vrhovsek, and F. Mattivi, Combining intensity correlation analysis and MALDI imaging to study the distribution of flavonols and dihydrochalcones in Golden Delicious apples, Journal of Experimental Botany, vol.63, issue.3, pp.1123-1133, 2012.
DOI : 10.1093/jxb/err327

G. , L. Regina, T. Sarkar, and R. Bai, New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies, Journal of Medicinal Chemistry, vol.52, issue.23, pp.7512-7527, 2009.

V. Palermo, L. Pieri, R. Silvestri, G. L. Regina, C. Falcone et al., Drug-induced inhibition of tubulin polymerization induces mitochondrion-mediated apoptosis in yeast, Cell Cycle, vol.10, issue.18, pp.3208-3209, 2011.
DOI : 10.4161/cc.10.18.16514

C. Mazzoni and C. Falcone, mRNA stability and control of cell proliferation: Figure 1, Biochemical Society Transactions, vol.73, issue.5, pp.1461-1465, 2011.
DOI : 10.1038/219588a0

C. Mazzoni and C. Falcone, Caspase-dependent apoptosis in yeast, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1783, issue.7, pp.1320-1327, 2008.
DOI : 10.1016/j.bbamcr.2008.02.015

V. Palermo, C. Falcone, and C. Mazzoni, Apoptosis and aging in mitochondrial morphology mutants ofS. cerevisiae, Folia Microbiologica, vol.5, issue.5, pp.479-483, 2007.
DOI : 10.1007/BF02932107

F. Madeo, E. Fröhlich, and M. Ligr, Oxygen Stress: A Regulator of Apoptosis in Yeast, The Journal of Cell Biology, vol.122, issue.4, pp.757-767, 1999.
DOI : 10.1016/S1097-2765(00)80034-9

A. Rigo, F. Vianello, and G. Clementi, Contribution of Proanthocyanidins to the Peroxy Radical Scavenging Capacity of Some Italian Red Wines, Journal of Agricultural and Food Chemistry, vol.48, issue.6, 1996.
DOI : 10.1021/jf991203d