?. References, National Institutes of Health Consensus Development Conference. Management of hepatitis C, Hepatology J. B, vol.36, issue.1 S1e2522, 2002.

A. Minello, B. Verges, J. M. Brun, P. Gambert, P. Hillon et al., Hepatitis C virus?associated hypobetalipoproteinemia is correlated with plasma viral load, steatosis, and liver fibrosis 1150?54. (3) Negro, F. Abnormalities of lipid metabolism in hepatitis C virus infection Chazouille? res, O.; Poupon, R. Hepatitis C virus induced hypobetalipoproteinemia: a possible mechanism for steatosis in chronic hepatitis C, Am. J. Gastroenterol. Gut J. Hepatol. E. A. B, vol.98, issue.34, pp.428-462, 2001.

L. Magnolo, L. Cattin, S. Bertolini, S. Calandra, S. O. Olofsson et al., Molecular diagnosis of hypobetalipoproteinemia: an ENID review Intracellular assembly of VLDL: two major steps in separate cell compartments Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteins, Atherosclerosis Trends Cardiovasc. Med. J. Biol. Chem, vol.195, issue.277, pp.19-27, 2000.

B. Ricci, Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice, 1287?98. (9), 1999.

L. P. Aggerbeck, R. E. Gregg, D. A. Gordon, and J. Wetterau, Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinemia, Nature, vol.365, issue.10, pp.65-74, 1993.

H. Wang, A. L. Goldberg, H. N. Ginsberg, S. G. Young, S. T. Hubl et al., The degradation of apolipoprotein B100 is mediated by the ubiquitin proteasome pathway and involves heat shock protein 70 Familial hypobetalipoproteinemia caused by a mutation in the apolipoprotein B gene that results in a truncated species of apolipoprotein B (B-31). A unique mutation that helps to define the portion of the apolipoprotein B molecule required for the formation of buoyant, triglyceride-rich lipoproteins, Hepatitis C virus nonstructural proteins inhibit apolipoprotein B100 secretion, pp.933-975, 1990.

H. Huang, F. Sun, D. M. Owen, W. Li, Y. Chen et al., Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins, Proc. Natl, 2005.
DOI : 10.1073/pnas.0700760104

L. Amicone, M. Tripodi, D. L. Diamond, J. M. Jacobs, B. Paeper et al., Proteomic profiling of human liver biopsies: hepatitis C virus-induced fibrosis and mitochondrial dysfunction A proteomic approach identifies proteins in hepatocytes that bind nascent apolipoprotein B Apolipoprotein B binds ferritin by hemin-mediated binding: evidence of direct binding of apolipoprotein B and ferritin to hemin Ferritins can regulate the secretion of apolipoprotein B Role for NF-kappa B in the regulation of ferritin H by tumor necrosis factor-alpha Regulation of ferritin genes and protein Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus, 3505?16. (21) Ahn, pp.378-86, 1995.

Z. Zhao, K. Murthy, A. Habermann, H. G. Kra?-usslich, M. Mizokami et al., Production of infectious hepatitis C virus in tissue culture from a cloned viral genome Iron storage, lipid peroxidation and glutathione turnover in chronic anti-HCV positive hepatitis, Nat. Med. J. Hepatol. J. D, vol.11, issue.22, pp.791-797, 1995.

M. J. Pippard and H. A. Huebers, Plasma ferritin determination as a diagnostic tool, 657?63. (25) Nishina, 1986.

T. Gondo, M. Tabuchi, F. Kishi, K. Hino, P. Gastaminza et al., Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription, Gastroenterology, vol.134, pp.226-264, 2008.

F. Chisari, P. Arosio, R. Ingrassia, and P. Cavadini, Cellular determinants of hepatitis C virus assembly, maturation, degradation, and secretion Ferritins: a family of molecules for iron storage, antioxidation and more, J. Virol. Biochim. Biophys. Acta, vol.82, pp.2120-2129, 1790.

V. Pazienza, B. Pittet-cuenod, C. A. Meier, F. Negro, R. J. Fontana et al., Monocyte chemoattractant protein-1 secreted by adipose tissue induces direct lipid accumulation in hepatocytes Iron reduction before and during interferon therapy of chronic hepatitis C: results of a multicenter, randomized, controlled trial, Hepatology Hepatology, vol.48, pp.799-807, 2000.

E. C. Gabazza, Y. Adachi, Y. Kojima, N. Nakagawa, and S. Watanabe, Iron reduction therapy by phlebotomy reduces lipid peroxidation and oxidative stress in patients with chronic hepatitis C, 921?2. (31) Furutani, 2006.

I. Sakaida, K. Okita, and R. D. Delima, Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein, Gastroenterology, vol.130, issue.32, 2006.

D. Johnstone, C. E. Herbison, M. J. Firth, R. Leary, E. A. Milward et al., Hepatic iron loading in mice increases cholesterol biosynthesis, 462?71. (33) Nishina, 2010.

T. Gondo, M. Tabuchi, F. Kishi, and K. Hino, Hepatitis C virus protein and iron overload induce hepatic steatosis through the unfolded protein response in mice, Liver Int, vol.30, pp.683-92, 2010.