Hospitalization risk of the 2009 H1N1 pandemic cases in Hong Kong.

Abstract : BACKGROUND: Reliable assessment for the severity of the 2009 H1N1 pandemic influenza is critical for evaluation of vaccination strategies for future pandemics. This study aims to estimate the age-specific hospitalization risks of the 2009 pandemic cases during the first wave in Hong Kong, by combining the findings from the serology and disease burden studies. METHODS: Excess hospitalization rates associated with the pandemic H1N1 were estimated from Poisson regression models fitted to weekly total numbers of non-accidental hospitalization from 2005 to 2010. Age-specific infection-hospitalization risks were calculated as excess hospitalization rates divided by the attack rates in the corresponding age group, which were estimated from serology studies previously conducted in Hong Kong. RESULTS: Excess hospitalization rate associated with pandemic H1N1 was highest in the 0-4 age group (881.3 per 100,000 population), followed by the 5-14, 60+, 15-29, 50-59, 30-39 and 40-49 age groups. The hospitalization risk of the infected cases (i.e. infection-hospitalization risk) was found highest in the 60+ age group and lowest in the 15-29 age group, with the estimates of 17.5% and 0.7%, respectively. CONCLUSIONS: People aged 60 or over had a relatively high infection-hospitalization risk during the first wave of the 2009 H1N1 pandemic, despite of a low attack rate in this age group. The findings support the policy of listing older people as the priority group for pandemic vaccination.
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Submitted on : Wednesday, March 12, 2014 - 3:34:42 PM
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Xi-Ling Wang, Chit-Ming Wong, Kwok-Hung Chan, King-Pan Chan, Pei-Hua Cao, et al.. Hospitalization risk of the 2009 H1N1 pandemic cases in Hong Kong.. BMC Infectious Diseases, BioMed Central, 2014, 14, pp.32. ⟨10.1186/1471-2334-14-32⟩. ⟨pasteur-00958480⟩

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