Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, EpiSciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Novel approaches to study the involvement of α7-nAChR in human diseases.

Abstract : The alpha7 nicotinic acetylcholine receptor (α7 nAChR) is widely distributed in the human brain and has been implicated in a number of human central nervous system (CNS) diseases, including Alzheimer's and Parkinson's disease, schizophrenia and autism. Recently, new roles for α7 nAChRs in lung cancer and heart disease have been elucidated. Despite the importance of this receptor in human pathology, many technical difficulties are still encountered when investigating the role of α7 nAChRs. Electrophysiological analysis of the receptor upon heterologous expression or in human tissues was limited by the fast desensitization of α7-mediated nicotinic currents and by tissue availability. In addition, animal models for the human diseases related to α7 nAChRs have long been unavailable. The recent development of new imaging and analysis approaches such as PET and receptor microtransplantation have rendered the study of α7 nAChRs increasingly feasible, paving new roads to the design of therapeutic drugs. This review summarizes the current knowledge and recent findings obtained by these novel approaches.
Document type :
Journal articles
Complete list of metadata
Contributor : Istituto Pasteur Fondazione Cenci Bolognetti Connect in order to contact the contributor
Submitted on : Thursday, March 20, 2014 - 12:08:18 PM
Last modification on : Wednesday, November 3, 2021 - 2:18:08 PM


  • HAL Id : pasteur-00961610, version 1
  • PUBMED : 22300023



Eleonora Palma, Luca Conti, Cristina Roseti, Cristina Limatola. Novel approaches to study the involvement of α7-nAChR in human diseases.. Current Drug Targets, Bentham Science Publishers, 2012, 13 (5), pp.579-86. ⟨pasteur-00961610⟩



Record views