NKG2D and DNAM-1 activating receptors and their ligands in NK-T cell interactions: role in the NK cell-mediated negative regulation of T cell responses.

Abstract : The negative regulation of adaptive immunity is relevant to maintain lymphocyte homeostasis. Several studies on natural killer (NK) cells have shown a previously unappreciated immunomodulatory role, as they can negatively regulate T cell-mediated immune responses by direct killing and by secretion of inhibitory cytokines. The molecular mechanisms of T cell suppression by NK cells, however, remained elusive. Only in the last few years has it become evident that, upon activation, human T cells express MICA-B, ULBP1-3, and PVR, ligands of the activating receptors NKG2D and DNAM-1, respectively. Their expression renders T cells targets of NK cell lysis, representing a new mechanism taking part to the negative regulation of T cell responses. Studies on the expression of NKG2D and DNAM-1 ligands on T cells have also contributed in understanding that the activation of ATM (ataxia-telangiectasia, mutated)/ATR (ATM/Rad3-related) kinases and the DNA damage response is a common pathway regulating the expression of activating ligands in different types of cells and under different conditions. The functional consequences of NKG2D and DNAM-1 ligand expression on activated T cells are discussed in the context of physiologic and pathologic processes such as infections, autoimmunity, and graft versus host disease.
Document type :
Journal articles
Complete list of metadatas

Cited literature [67 references]  Display  Hide  Download

https://hal-riip.archives-ouvertes.fr/pasteur-00966878
Contributor : Istituto Pasteur Fondazione Cenci Bolognetti <>
Submitted on : Thursday, March 27, 2014 - 3:01:52 PM
Last modification on : Tuesday, August 13, 2019 - 11:00:19 AM
Long-term archiving on : Monday, April 10, 2017 - 4:25:37 AM

File

Zingonietal2012.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Alessandra Zingoni, Michele Ardolino, Angela Santoni, Cristina Cerboni. NKG2D and DNAM-1 activating receptors and their ligands in NK-T cell interactions: role in the NK cell-mediated negative regulation of T cell responses.. Frontiers in Immunology, Frontiers, 2012, 3, pp.408. ⟨10.3389/fimmu.2012.00408⟩. ⟨pasteur-00966878⟩

Share

Metrics

Record views

222

Files downloads

240