Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action. - Archive ouverte HAL Access content directly
Journal Articles Bioorganic and Medicinal Chemistry Year : 2012

Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action.

(1) , (2) , (1) , (1) , (1) , (3) , (4) , (2) , (2) , (2) , (1)
1
2
3
4

Abstract

A set of polyphenol compounds was synthesized and assayed for their ability in inhibiting influenza A virus replication. A sub-set of them showed low toxicity. The best compounds within this sub-set were 4 and 6g, which inhibited the viral replication in a dose-dependent manner. The antiviral activity of these molecules was demonstrated to be caused by their interference with intracellular pathways exploited for viral replication: (1) MAP kinases controlling nuclear-cytoplasmic traffic of viral ribonucleoprotein complex; (2) redox-sensitive pathways, involved in maturation of viral hemagglutinin protein.
Embargoed file
Embargoed file
Ne sera jamais visible
Loading...

Dates and versions

pasteur-00968715 , version 1 (01-04-2014)

Identifiers

Cite

Rossella Fioravanti, Ignacio Celestino, Roberta Costi, Giuliana Cuzzucoli Crucitti, Luca Pescatori, et al.. Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action.. Bioorganic and Medicinal Chemistry, 2012, 20 (16), pp.5046-52. ⟨10.1016/j.bmc.2012.05.062⟩. ⟨pasteur-00968715⟩

Collections

RIIP RIIP_FCB
48 View
1 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More