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Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action.

Rossella Fioravanti 1 Ignacio Celestino 2 Roberta Costi 1, * Giuliana Cuzzucoli Crucitti 1 Luca Pescatori 1 Leonardo Mattiello 3 Ettore Novellino 4 Paola Checconi 2 Anna Teresa Palamara 2 Lucia Nencioni 2 Roberto Di Santo 1 
* Corresponding author
1 Department of Medicinal Chemistry and Technologies
2 Department of Public Health and Infectious Diseases
3 Dipartimento di Dip. di Scienze di Base e Applicate per l'Ingegneria
4 Department of Pharmacy Naples
Abstract : A set of polyphenol compounds was synthesized and assayed for their ability in inhibiting influenza A virus replication. A sub-set of them showed low toxicity. The best compounds within this sub-set were 4 and 6g, which inhibited the viral replication in a dose-dependent manner. The antiviral activity of these molecules was demonstrated to be caused by their interference with intracellular pathways exploited for viral replication: (1) MAP kinases controlling nuclear-cytoplasmic traffic of viral ribonucleoprotein complex; (2) redox-sensitive pathways, involved in maturation of viral hemagglutinin protein.
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Submitted on : Tuesday, April 1, 2014 - 2:30:20 PM
Last modification on : Wednesday, November 3, 2021 - 2:18:08 PM
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Rossella Fioravanti, Ignacio Celestino, Roberta Costi, Giuliana Cuzzucoli Crucitti, Luca Pescatori, et al.. Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action.. Bioorganic and Medicinal Chemistry, Elsevier, 2012, 20 (16), pp.5046-52. ⟨10.1016/j.bmc.2012.05.062⟩. ⟨pasteur-00968715⟩

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