Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action.

Rossella Fioravanti (1) , Ignacio Celestino (2) , Roberta Costi (1) , Giuliana Cuzzucoli Crucitti (1) , Luca Pescatori (1) , Leonardo Mattiello (3) , Ettore Novellino (4) , Paola Checconi (2) , Anna Teresa Palamara (2) , Lucia Nencioni (2) , Roberto Di Santo (1)

1 Department of Medicinal Chemistry and Technologies
2 Department of Public Health and Infectious Diseases
3 Dipartimento di Dip. di Scienze di Base e Applicate per l'Ingegneria
4 Department of Pharmacy Naples

A set of polyphenol compounds was synthesized and assayed for their ability in inhibiting influenza A virus replication. A sub-set of them showed low toxicity. The best compounds within this sub-set were 4 and 6g, which inhibited the viral replication in a dose-dependent manner. The antiviral activity of these molecules was demonstrated to be caused by their interference with intracellular pathways exploited for viral replication: (1) MAP kinases controlling nuclear-cytoplasmic traffic of viral ribonucleoprotein complex; (2) redox-sensitive pathways, involved in maturation of viral hemagglutinin protein.

Domains: Pharmaceutical sciences

Rossella Fioravanti, Ignacio Celestino, Roberta Costi, Giuliana Cuzzucoli Crucitti, Luca Pescatori, et al.. Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action.. Bioorganic and Medicinal Chemistry, 2012, 20 (16), pp.5046-52. ⟨10.1016/j.bmc.2012.05.062⟩. ⟨pasteur-00968715⟩