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Journal articles
Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action.
Rossella Fioravanti
1
Ignacio Celestino
2
Roberta Costi
1, *
Giuliana Cuzzucoli Crucitti
1
Luca Pescatori
1
Leonardo Mattiello
3
Ettore Novellino
4
Paola Checconi
2
Anna Teresa Palamara
2
Lucia Nencioni
2
Roberto Di Santo
1
Rossella Fioravanti 1
Author
Ignacio Celestino 2
Author
Roberta Costi 1
Correspondent author
Giuliana Cuzzucoli Crucitti 1
Author
Luca Pescatori 1
Author
Leonardo Mattiello 3
Author
Ettore Novellino 4
Author
Paola Checconi 2
Author
1
Department of Medicinal Chemistry and Technologies (Piazzale Aldo Moro 5, I-00185, Rome - Italy)
- Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti (Université de Rome La Sapienza 5 Place Aldo Moro 00185 Rome - Italy)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
- Università degli Studi di Roma "La Sapienza" [Rome] (Piazzale Aldo Moro 5, 00185 Roma - Italy)
2
Department of Public Health and Infectious Diseases (Italy)
- Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti (Université de Rome La Sapienza 5 Place Aldo Moro 00185 Rome - Italy)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
- Università degli Studi di Roma "La Sapienza" [Rome] (Piazzale Aldo Moro 5, 00185 Roma - Italy)
3
Dipartimento di Dip. di Scienze di Base e Applicate per l'Ingegneria (Italy)
- Università degli Studi di Roma "La Sapienza" [Rome] (Piazzale Aldo Moro 5, 00185 Roma - Italy)
4
Department of Pharmacy Naples (University of Naples Federico II, via D. Montesano 49, I-80131 Naples - Italy)
- Université de Naples (France)
Abstract : A set of polyphenol compounds was synthesized and assayed for their ability in inhibiting influenza A virus replication. A sub-set of them showed low toxicity. The best compounds within this sub-set were 4 and 6g, which inhibited the viral replication in a dose-dependent manner. The antiviral activity of these molecules was demonstrated to be caused by their interference with intracellular pathways exploited for viral replication: (1) MAP kinases controlling nuclear-cytoplasmic traffic of viral ribonucleoprotein complex; (2) redox-sensitive pathways, involved in maturation of viral hemagglutinin protein.
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Journal articles
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https://hal-riip.archives-ouvertes.fr/pasteur-00968715
Contributor : Istituto Pasteur Fondazione Cenci Bolognetti <>
Submitted on : Tuesday, April 1, 2014 - 2:30:20 PM
Last modification on : Wednesday, October 28, 2020 - 3:20:08 PM
Long-term archiving on: : Monday, April 10, 2017 - 8:16:55 AM
Contributor : Istituto Pasteur Fondazione Cenci Bolognetti <>
Submitted on : Tuesday, April 1, 2014 - 2:30:20 PM
Last modification on : Wednesday, October 28, 2020 - 3:20:08 PM
Long-term archiving on: : Monday, April 10, 2017 - 8:16:55 AM
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Identifiers
- HAL Id : pasteur-00968715, version 1
- DOI : 10.1016/j.bmc.2012.05.062
- PUBMED : 22743086
Citation
Rossella Fioravanti, Ignacio Celestino, Roberta Costi, Giuliana Cuzzucoli Crucitti, Luca Pescatori, et al.. Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action.. Bioorganic and Medicinal Chemistry, Elsevier, 2012, 20 (16), pp.5046-52. ⟨10.1016/j.bmc.2012.05.062⟩. ⟨pasteur-00968715⟩
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