Venting-while-heating microwave-assisted synthesis of 3-arylthioindoles.

Giuseppe La Regina (1) , Valerio Gatti (1) , Valeria Famiglini (1) , Francesco Piscitelli (1) , Romano Silvestri (1)

1 Department of Medicinal Chemistry and Technologies

We report the first example of venting-while-heating microwave-assisted synthesis of a small library of 3-arylthioindoles. Compounds were prepared in excellent isolated yields (90-98%) within 4 min in a closed vessel by treating indoles with disulfides in the presence of sodium hydride in anhydrous N,N-dimethylformamide. The method was not affected by electron-donating and -withdrawing substituents both on 3-arylthio moiety and at 2- and 5-positions of the indole nucleus.

Domaines: Sciences pharmaceutiques

Giuseppe La Regina, Valerio Gatti, Valeria Famiglini, Francesco Piscitelli, Romano Silvestri. Venting-while-heating microwave-assisted synthesis of 3-arylthioindoles.. ACS Combinatorial Science, 2012, 14 (4), pp.258-62. ⟨10.1021/co200165j⟩. ⟨pasteur-00969577⟩