Dampening Host Sensing and Avoiding Recognition in Pseudomonas aeruginosa Pneumonia.

Cristina Cigana (1) , Nicola Ivan Lorè (1) , Maria Lina Bernardini (2, 3) , Alessandra Bragonzi (1)

1 Infections and Cystic Fibrosis Unit, Division of Immunology, Transplantation and Infectious Diseases
2 Dipartimento di Biologia Cellulare e dello Sviluppo
3 Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti

Pseudomonas aeruginosa is an opportunistic pathogen and causes a wide range of acute and chronic infections. P. aeruginosa infections are kept in check by an effective immune surveillance in the healthy host, while any imbalance or defect in the normal immune response can manifest in disease. Invasive acute infection in the immunocompromised patients is mediated by potent extracellular and cell bound bacterial virulence factors. Life-threatening chronic infection in cystic fibrosis patients is maintained by pathogenic variants that contribute to evade detection and clearance by the immune system. Here, we reviewed the molecular basis of receptor-mediated recognition of P. aeruginosa and their role in initiating inflammation and the colonization. In addition, the consequence of the P. aeruginosa genetic adaptation for the antibacterial defence and the maintaining of chronic infection are discussed.

Domains: Life Sciences [q-bio]; Microbiology and Parasitology

Cristina Cigana, Nicola Ivan Lorè, Maria Lina Bernardini, Alessandra Bragonzi. Dampening Host Sensing and Avoiding Recognition in Pseudomonas aeruginosa Pneumonia.. Journal of Biomedicine and Biotechnology, 2011, 2011, pp.852513. ⟨10.1155/2011/852513⟩. ⟨pasteur-00975374⟩