K. Labbe and M. Saleh, Cell death in the host response to infection, Cell Death and Differentiation, vol.8, issue.9, pp.1339-1349, 2008.
DOI : 10.1038/cdd.2008.91

V. Deretic and B. Levine, Autophagy, Immunity, and Microbial Adaptations, Cell Host & Microbe, vol.5, issue.6, pp.527-549, 2009.
DOI : 10.1016/j.chom.2009.05.016

URL : http://doi.org/10.1016/j.chom.2009.05.016

V. Mathan and M. Mathan, Intestinal Manifestations of Invasive Diarrheas and Their Diagnosis, Clinical Infectious Diseases, vol.13, issue.Supplement 4, pp.311-313, 1991.
DOI : 10.1093/clinids/13.Supplement_4.S311

P. Sansonetti, A. Ryter, P. Clerc, A. Maurelli, and J. Mounier, Multiplication of Shigella flexneri within HeLa cells: lysis of the phagocytic vacuole and plasmid-mediated contact hemolysis, Infect Immun, vol.51, pp.461-469, 1996.

C. Parsot, Shigella flexneri: Genetics of Entry and intercellular Dissemination in Epithelial Cells, Curr Top Microbiol Immunol, vol.192, pp.217-241, 1994.
DOI : 10.1007/978-3-642-78624-2_10

S. Girardin, I. Boneca, L. Carneiro, A. Antignac, M. Jehanno et al., Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan, Science, vol.300, issue.5625, pp.1584-1587, 2003.
DOI : 10.1126/science.1084677

T. Suzuki, L. Franchi, C. Toma, H. Ashida, M. Ogawa et al., Differential Regulation of Caspase-1 Activation, Pyroptosis, and Autophagy via Ipaf and ASC in Shigella-Infected Macrophages, PLoS Pathogens, vol.202, issue.8, p.111, 2007.
DOI : 0022-1007(2005)202[1235:IOCWCP]2.0.CO;2

H. Hilbi, Y. Chen, K. Thirumalai, and A. Zychlinsky, The interleukin 1beta-converting enzyme, caspase 1, is activated during Shigella flexneri-induced apoptosis in human monocytederived macrophages, Infect Immun, vol.65, pp.5165-5170, 1997.

J. Koterski, M. Nahvi, M. Venkatesan, and B. Haimovich, Virulent Shigella flexneri Causes Damage to Mitochondria and Triggers Necrosis in Infected Human Monocyte-Derived Macrophages, Infection and Immunity, vol.73, issue.1, pp.504-513, 2005.
DOI : 10.1128/IAI.73.1.504-513.2005

T. Nonaka, A. Kuwae, C. Sasakawa, and S. Imajoh-ohmi, YSH6000 induces two types of cell death, apoptosis and oncosis, in the differentiated human monoblastic cell line U937, FEMS Microbiology Letters, vol.174, issue.1, pp.89-95, 1999.
DOI : 10.1111/j.1574-6968.1999.tb13553.x

T. Suzuki, K. Nakanishi, H. Tsutsui, H. Iwai, S. Akira et al., A Novel Caspase-1/Toll-like Receptor 4-independent Pathway of Cell Death Induced by Cytosolic Shigella in Infected Macrophages, Journal of Biological Chemistry, vol.280, issue.14, pp.14042-14050, 2005.
DOI : 10.1074/jbc.M414671200

L. Carneiro, L. Travassos, F. Soares, I. Tattoli, J. Magalhaes et al., Shigella Induces Mitochondrial Dysfunction and Cell Death in Nonmyleoid Cells, Cell Host & Microbe, vol.5, issue.2, pp.123-136, 2009.
DOI : 10.1016/j.chom.2008.12.011

C. Faherty and A. Maurelli, Spa15 of Shigella flexneri Is Secreted through the Type III Secretion System and Prevents Staurosporine-Induced Apoptosis, Infection and Immunity, vol.77, issue.12, pp.5281-5290, 2009.
DOI : 10.1128/IAI.00800-09

I. Tattoli, L. Lembo-fazio, G. Nigro, L. Carneiro, E. Ferraro et al., Intracellular bacteriolysis triggers a massive apoptotic cell death in Shigella-infected epithelial cells, Microbes and Infection, vol.10, issue.10-11, pp.1114-1123, 2008.
DOI : 10.1016/j.micinf.2008.06.004

A. Cersini, A. Salvia, and M. Bernardini, Intracellular multiplication and virulence of Shigella flexneri auxotrophic mutants, Infect Immun, vol.66, pp.549-557, 1998.

N. Dupont, S. Lacas-gervais, J. Bertout, I. Paz, B. Freche et al., Shigella Phagocytic Vacuolar Membrane Remnants Participate in the Cellular Response to Pathogen Invasion and Are Regulated by Autophagy, Cell Host & Microbe, vol.6, issue.2, pp.137-149, 2009.
DOI : 10.1016/j.chom.2009.07.005

M. Gao, N. Guo, C. Huang, and L. Song, Diverse Roles of GADD45α in Stress Signaling, Current Protein & Peptide Science, vol.10, issue.4, pp.388-394, 2009.
DOI : 10.2174/138920309788922216

T. Tong, J. J. , J. S. Li, X. Fan, W. Song et al., Gadd45a Expression Induces Bim Dissociation from the Cytoskeleton and Translocation to Mitochondria, Molecular and Cellular Biology, vol.25, issue.11, pp.4488-4500, 2005.
DOI : 10.1128/MCB.25.11.4488-4500.2005

Y. Li, H. Qian, X. Li, H. Wang, Y. J. Liu et al., Adenoviral-mediated gene transfer of Gadd45a results in suppression by inducing apoptosis and cell cycle arrest in pancreatic cancer cell, The Journal of Gene Medicine, vol.255, issue.1, pp.3-13, 2009.
DOI : 10.1002/jgm.1270

L. Zerbini, Y. Wang, A. Czibere, R. Correa, J. Cho et al., NF-??B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45?? and ?? is essential for cancer cell survival, Proceedings of the National Academy of Sciences, vol.101, issue.37, pp.13618-13623, 2004.
DOI : 10.1073/pnas.0402069101

M. Martino, G. Rossi, I. Martini, I. Tattoli, D. Chiavolini et al., Mucosal Lymphoid Infiltrate Dominates Colonic Pathological Changes in Murine Experimental Shigellosis, The Journal of Infectious Diseases, vol.192, issue.1, pp.136-148, 2005.
DOI : 10.1086/430740

O. Reilly, M. Staversky, R. Watkins, R. Maniscalco, W. Keng et al., p53-independent induction of GADD45 and GADD153 in mouse lungs exposed to hyperoxia, Am J Physiol Lung Cell Mol Physiol, vol.278, pp.552-559, 2003.

T. Rudel, O. Kepp, and V. Kozjak-pavlovic, Interactions between bacterial pathogens and mitochondrial cell death pathways, Nature Reviews Microbiology, vol.8, issue.10, pp.693-705, 2010.
DOI : 10.1038/nrmicro2421

S. Srinivasula and J. Ashwell, IAPs: What's in a Name?, Molecular Cell, vol.30, issue.2, pp.123-135, 2008.
DOI : 10.1016/j.molcel.2008.03.008

J. Downward, PI 3-kinase, Akt and cell survival, Seminars in Cell & Developmental Biology, vol.15, issue.2, pp.177-182, 2004.
DOI : 10.1016/j.semcdb.2004.01.002

T. Pedron, C. Thibault, and P. Sansonetti, The Invasive Phenotype of Shigella flexneri Directs a Distinct Gene Expression Pattern in the Human Intestinal Epithelial Cell Line Caco-2, Journal of Biological Chemistry, vol.278, issue.36, pp.33878-33886, 2003.
DOI : 10.1074/jbc.M303749200

J. Chipuk, T. Moldoveanu, F. Llambi, M. Parsons, and D. Green, The BCL-2 Family Reunion, Molecular Cell, vol.37, issue.3, pp.299-310, 2010.
DOI : 10.1016/j.molcel.2010.01.025

A. Rasola, M. Sciacovelli, B. Pantic, and P. Bernardi, Signal transduction to the permeability transition pore, FEBS Letters, vol.304, issue.10, pp.1989-1996, 2010.
DOI : 10.1016/j.febslet.2010.02.022

D. Gramaglia, A. Gentile, M. Battaglia, L. Ranzato, V. Petronilli et al., Apoptosis to necrosis switching downstream of apoptosome formation requires inhibition of both glycolysis and oxidative phosphorylation in a BCL-XL- and PKB/AKT-independent fashion, Cell Death and Differentiation, vol.11, issue.3, pp.342-353, 2004.
DOI : 10.1038/sj.cdd.4401326

P. Nicotera and G. Melino, Regulation of the apoptosis???necrosis switch, Oncogene, vol.23, issue.16, pp.2757-2765, 2004.
DOI : 10.1038/sj.onc.1207559

S. Orrenius, B. Zhivotovsky, and P. Nicotera, Calcium: Regulation of cell death: the calcium???apoptosis link, Nature Reviews Molecular Cell Biology, vol.4, issue.7, pp.552-565, 2003.
DOI : 10.1038/nrm1150

A. Rasola and P. Bernardi, The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesis, Apoptosis, vol.32, issue.Suppl. 3, pp.815-833, 2007.
DOI : 10.1007/s10495-007-0723-y

R. Siafakas, A. Richardson, and D. , Growth arrest and DNA damage-45 alpha (GADD45??), The International Journal of Biochemistry & Cell Biology, vol.41, issue.5, pp.986-989, 2009.
DOI : 10.1016/j.biocel.2008.06.018

B. Hoffman and D. Liebermann, Gadd45 modulation of intrinsic and extrinsic stress responses in myeloid cells, Journal of Cellular Physiology, vol.18, issue.1, pp.26-31, 2009.
DOI : 10.1002/jcp.21582

Y. Hasegawa, J. Mans, S. Mao, M. Lopez, H. Baker et al., Gingival Epithelial Cell Transcriptional Responses to Commensal and Opportunistic Oral Microbial Species, Infection and Immunity, vol.75, issue.5, pp.2540-2547, 2007.
DOI : 10.1128/IAI.01957-06

C. Martinoli, A. Chiavelli, and M. Rescigno, Entry Route of Salmonella typhimurium Directs the Type of Induced Immune Response, Immunity, vol.27, issue.6, pp.975-984, 2007.
DOI : 10.1016/j.immuni.2007.10.011

A. Rasola and M. Geuna, A flow cytometry assay simultaneously detects independent apoptotic parameters, Cytometry, vol.10, issue.2, pp.151-157, 2001.
DOI : 10.1002/1097-0320(20011001)45:2<151::AID-CYTO1157>3.0.CO;2-I

K. Livak and T. Schmittgen, Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2???????CT Method, Methods, vol.25, issue.4, pp.402-408, 2001.
DOI : 10.1006/meth.2001.1262

A. Resendes, N. Majo, J. Segales, J. Espadamala, E. Mateu et al., Apoptosis in normal lymphoid organs from healthy normal, conventional pigs at different ages detected by TUNEL and cleaved caspase-3 immunohistochemistry in paraffin-embedded tissues, Veterinary Immunology and Immunopathology, vol.99, issue.3-4, pp.203-213, 2004.
DOI : 10.1016/j.vetimm.2004.02.001