Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, EpiSciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Terminin: a protein complex that mediates epigenetic maintenance of Drosophila telomeres.

Abstract : In most organisms, telomeres are extended by telomerase and contain GC-rich repeats. Drosophila telomeres are elongated by occasional transposition of specialized retroelements rather than telomerase activity, and are assembled independently of the sequence of the DNA termini. Recent work has shown that Drosophila telomeres are capped by a complex, we call terminin, which includes HOAP, HipHop, Moi and Ver; these are fast-evolving proteins that prevent telomere fusion, directly interact with each other, and appear to localize and function only at telomeres. With the possible exception of Ver that contains an OB fold domain structurally similar to the Stn1 OB fold, none of the terminin proteins is evolutionarily conserved outside the Drosophila species. Human telomeres are protected by the shelterin complex, which comprises six proteins that bind chromosome ends in a sequence-dependent manner. Shelterin subunits are not fast-evolving proteins and are not conserved in flies, but localize and function only at telomeres like the terminin components. Based on these findings, we propose that concomitant with telomerase loss Drosophila rapidly evolved terminin to bind chromosome ends in a sequence-independent fashion, and that terminin is functionally analogous to shelterin.
Complete list of metadata

Cited literature [77 references]  Display  Hide  Download
Contributor : Istituto Pasteur Fondazione Cenci Bolognetti Connect in order to contact the contributor
Submitted on : Friday, April 11, 2014 - 3:21:59 PM
Last modification on : Thursday, January 6, 2022 - 5:30:02 PM
Long-term archiving on: : Monday, April 10, 2017 - 12:06:54 PM


Files produced by the author(s)




Grazia D Raffa, Laura Ciapponi, Giovanni Cenci, Maurizio Gatti. Terminin: a protein complex that mediates epigenetic maintenance of Drosophila telomeres.. Nucleus, European Nuclear Society, 2011, 2 (5), pp.383-91. ⟨10.4161/nucl.2.5.17873⟩. ⟨pasteur-00977757⟩



Record views


Files downloads