A. Sanchez and I. Fabregat, Growth factor- and cytokine-driven pathways governing liver stemness and differentiation, World Journal of Gastroenterology, vol.16, issue.41, pp.5148-5161, 2010.
DOI : 10.3748/wjg.v16.i41.5148

L. Santangelo, A. Marchetti, C. Cicchini, A. Conigliaro, B. Conti et al., The stable repression of mesenchymal program is required for hepatocyte identity: A novel role for hepatocyte nuclear factor 4??, Hepatology, vol.51, issue.6, pp.2063-2074, 2011.
DOI : 10.1002/hep.24280

URL : https://hal.archives-ouvertes.fr/pasteur-00980177

T. Graf and M. Stadtfeld, Heterogeneity of Embryonic and Adult Stem Cells, Cell Stem Cell, vol.3, issue.5, pp.480-483, 2008.
DOI : 10.1016/j.stem.2008.10.007

M. Colletti, C. Cicchini, A. Conigliaro, L. Santangelo, T. Alonzi et al., Convergence of Wnt Signaling on the HNF4??-Driven Transcription in Controlling Liver Zonation, Gastroenterology, vol.137, issue.2, pp.660-672, 2009.
DOI : 10.1053/j.gastro.2009.05.038

C. Cicchini, D. Filippini, S. Coen, A. Marchetti, C. Cavallari et al., Snail controls differentiation of hepatocytes by repressing HNF4?? expression, Journal of Cellular Physiology, vol.98, issue.1, pp.230-238, 2006.
DOI : 10.1002/jcp.20730

S. Mani, W. Guo, M. Liao, E. Eaton, A. Ayyanan et al., The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells, Cell, vol.133, issue.4, pp.704-715, 2008.
DOI : 10.1016/j.cell.2008.03.027

J. Polo and K. Hochedlinger, When Fibroblasts MET iPSCs, Cell Stem Cell, vol.7, issue.1, pp.5-6, 2010.
DOI : 10.1016/j.stem.2010.05.018

R. Li, J. Liang, S. Ni, T. Zhou, X. Qing et al., A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts, Cell Stem Cell, vol.7, issue.1, pp.51-63, 2010.
DOI : 10.1016/j.stem.2010.04.014

U. Wellner, J. Schubert, U. Burk, O. Schmalhofer, F. Zhu et al., The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs, Nature Cell Biology, vol.5, issue.12, pp.1487-1495, 2009.
DOI : 10.1016/S1567-133X(03)00147-9

G. Eades, Y. Yao, M. Yang, Y. Zhang, S. Chumsri et al., miR-200a Regulates SIRT1 Expression and Epithelial to Mesenchymal Transition (EMT)-like Transformation in Mammary Epithelial Cells, Journal of Biological Chemistry, vol.286, issue.29, pp.25992-26002, 2011.
DOI : 10.1074/jbc.M111.229401

C. Tarantino, G. Paolella, L. Cozzuto, G. Minopoli, L. Pastore et al., miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells, The FASEB Journal, vol.24, issue.9, pp.3255-3263, 2010.
DOI : 10.1096/fj.09-152207

F. Spagnoli, C. Cicchini, M. Tripodi, and M. Weiss, Inhibition of MMH (Met murine hepatocyte) cell differentiation by TGF(beta) is abrogated by pre-treatment with the heritable differentiation effector FGF1, J Cell Sci, vol.113, pp.3639-3647, 2000.

G. Hayhurst, Y. Lee, G. Lambert, J. Ward, and F. Gonzalez, Hepatocyte Nuclear Factor 4?? (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis, Molecular and Cellular Biology, vol.21, issue.4, pp.1393-1403, 2001.
DOI : 10.1128/MCB.21.4.1393-1403.2001

M. Nagaki and H. Moriwaki, Transcription factor HNF and hepatocyte differentiation, Hepatology Research, vol.44, issue.10, pp.961-969, 2008.
DOI : 10.1111/j.1872-034X.2008.00367.x

V. Stanulovic, I. Kyrmizi, M. Kruithof-de-julio, M. Hoogenkamp, J. Vermeulen et al., Hepatic HNF4?? deficiency induces periportal expression of glutamine synthetase and other pericentral enzymes, Hepatology, vol.158, issue.12B, pp.433-444, 2007.
DOI : 10.1002/hep.21456

S. Takagi, M. Nakajima, K. Kida, Y. Yamaura, T. Fukami et al., MicroRNAs Regulate Human Hepatocyte Nuclear Factor 4??, Modulating the Expression of Metabolic Enzymes and Cell Cycle, Journal of Biological Chemistry, vol.285, issue.7, pp.4415-4422, 2010.
DOI : 10.1074/jbc.M109.085431

J. Gill, E. Langer, R. Lindsley, M. Cai, T. Murphy et al., Snail and the microRNA-200 Family Act in Opposition to Regulate Epithelial-to-Mesenchymal Transition and Germ Layer Fate Restriction in Differentiating ESCs, STEM CELLS, vol.29, issue.5, pp.764-776, 2011.
DOI : 10.1002/stem.628

M. Battle, G. Konopka, F. Parviz, A. Gaggl, C. Yang et al., Hepatocyte nuclear factor 4?? orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver, Proceedings of the National Academy of Sciences, vol.103, issue.22, pp.8419-8424, 2006.
DOI : 10.1073/pnas.0600246103

N. Lazarevich, O. Cheremnova, E. Varga, D. Ovchinnikov, E. Kudrjavtseva et al., Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors, Hepatology, vol.968, issue.4, pp.1038-1047, 2004.
DOI : 10.1002/hep.20155

S. Park, A. Gaur, E. Lengyel, and M. Peter, The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2, Genes & Development, vol.22, issue.7, pp.894-907, 2008.
DOI : 10.1101/gad.1640608

M. Korpal, E. Lee, G. Hu, and Y. Kang, The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional Repressors ZEB1 and ZEB2, Journal of Biological Chemistry, vol.283, issue.22, pp.14910-14914, 2008.
DOI : 10.1074/jbc.C800074200

L. He, X. He, L. Lim, E. De-stanchina, Z. Xuan et al., A microRNA component of the p53 tumour suppressor network, Nature, vol.296, issue.7148, pp.1130-1134, 2007.
DOI : 10.1038/nature05939

T. Chang, E. Wentzel, O. Kent, K. Ramachandran, M. Mullendore et al., Transactivation of miR-34a by p53 Broadly??Influences Gene Expression and??Promotes??Apoptosis, Molecular Cell, vol.26, issue.5, pp.745-752, 2007.
DOI : 10.1016/j.molcel.2007.05.010

M. Yamakuchi, M. Ferlito, and C. Lowenstein, miR-34a repression of SIRT1 regulates apoptosis, Proceedings of the National Academy of Sciences, vol.105, issue.36, pp.13421-13426, 2008.
DOI : 10.1073/pnas.0801613105

D. Odom, N. Zizlsperger, D. Gordon, G. Bell, N. Rinaldi et al., Control of Pancreas and Liver Gene Expression by HNF Transcription Factors, Science, vol.303, issue.5662, pp.1378-1381, 2004.
DOI : 10.1126/science.1089769

E. Bolotin, H. Liao, T. Ta, C. Yang, W. Hwang-verslues et al., Integrated approach for the identification of human hepatocyte nuclear factor 4?? target genes using protein binding microarrays, Hepatology, vol.4, issue.9, pp.642-653, 2010.
DOI : 10.1002/hep.23357

Z. Li, Y. Xi, W. Zhu, C. Zeng, Z. Zhang et al., Positive regulation of hepatic miR-122 expression by HNF4??, Journal of Hepatology, vol.55, issue.3, pp.602-611, 2011.
DOI : 10.1016/j.jhep.2010.12.023

H. Xu, J. He, Z. Xiao, Q. Zhang, Y. Chen et al., Liver-enriched transcription factors regulate MicroRNA-122 that targets CUTL1 during liver development, Hepatology, vol.49, issue.4, pp.1431-1442, 2010.
DOI : 10.1002/hep.23818

D. Kosman, Y. Ip, M. Levine, and K. Arora, Establishment of the mesoderm-neuroectoderm boundary in the Drosophila embryo, Science, vol.254, issue.5028, pp.118-122, 1991.
DOI : 10.1126/science.1925551

H. Kataoka, T. Murayama, M. Yokode, S. Mori, H. Sano et al., A novel Snail-related transcription factor Smuc regulates basic helix-loop-helix transcription factor activities via specific E-box motifs, Nucleic Acids Research, vol.28, issue.2, pp.626-633, 2000.
DOI : 10.1093/nar/28.2.626

A. Conigliaro, M. Colletti, C. Cicchini, M. Guerra, R. Manfredini et al., Isolation and characterization of a murine resident liver stem cell, Cell Death and Differentiation, vol.36, issue.1, pp.123-133, 2008.
DOI : 10.1083/jcb.90.2.339

G. Martello, A. Rosato, F. Ferrari, A. Manfrin, M. Cordenonsi et al., A MicroRNA Targeting Dicer for Metastasis Control, Cell, vol.141, issue.7, pp.1195-1207, 2010.
DOI : 10.1016/j.cell.2010.05.017

U. Burk, J. Schubert, U. Wellner, O. Schmalhofer, E. Vincan et al., A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells, EMBO reports, vol.61, issue.6, pp.582-589, 2008.
DOI : 10.1016/j.cell.2004.06.006