Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E. - RIIP - Réseau International des Instituts Pasteur Accéder directement au contenu
Article Dans Une Revue Nature Immunology Année : 2012

Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E.

Résumé

Type I interferon is an integral component of the antiviral response, and its production is tightly controlled at the levels of transcription and translation. The eukaryotic translation-initiation factor eIF4E is a rate-limiting factor whose activity is regulated by phosphorylation of Ser209. Here we found that mice and fibroblasts in which eIF4E cannot be phosphorylated were less susceptible to virus infection. More production of type I interferon, resulting from less translation of Nfkbia mRNA (which encodes the inhibitor IκBα), largely explained this phenotype. The lower abundance of IκBα resulted in enhanced activity of the transcription factor NF-κB, which promoted the production of interferon-β (IFN-β). Thus, regulated phosphorylation of eIF4E has a key role in antiviral host defense by selectively controlling the translation of an mRNA that encodes a critical suppressor of the innate antiviral response.
Fichier sous embargo
Fichier sous embargo
Date de visibilité indéterminée
Loading...

Dates et versions

pasteur-01002317 , version 1 (05-06-2014)

Identifiants

Citer

Barbara Herdy, Maritza Jaramillo, Yuri V Svitkin, Amy B Rosenfeld, Mariko Kobayashi, et al.. Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E.. Nature Immunology, 2012, 13 (6), pp.543-50. ⟨10.1038/ni.2291⟩. ⟨pasteur-01002317⟩

Collections

RIIP INRS-IAF
218 Consultations
2 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More