I. Crispe, The Liver as a Lymphoid Organ, Annual Review of Immunology, vol.27, issue.1, pp.147-63, 2009.
DOI : 10.1146/annurev.immunol.021908.132629

G. Tiegs and A. Lohse, Immune tolerance: What is unique about the liver, Journal of Autoimmunity, vol.34, issue.1, pp.1-6, 2010.
DOI : 10.1016/j.jaut.2009.08.008

A. Thomson and P. Knolle, Antigen-presenting cell function in the tolerogenic liver environment, Nature Reviews Immunology, vol.25, issue.11, pp.753-66, 2010.
DOI : 10.1038/nri2858

E. Krawitt, Autoimmune Hepatitis, New England Journal of Medicine, vol.354, issue.1, pp.54-66, 2006.
DOI : 10.1056/NEJMra050408

D. Bowen, M. Zen, L. Holz, T. Davis, G. Mccaughan et al., The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity, Journal of Clinical Investigation, vol.114, issue.5, pp.701-713, 2004.
DOI : 10.1172/JCI21593DS1

A. Teufel, P. Galle, and S. Kanzler, Update on autoimmune hepatitis, World Journal of Gastroenterology, vol.15, issue.9, pp.1035-1076, 2009.
DOI : 10.3748/wjg.15.1035

D. Vergani and G. Mieli-vergani, Aetiopathogenesis of autoimmune hepatitis, World Journal of Gastroenterology, vol.14, issue.21, pp.3306-3318, 2008.
DOI : 10.3748/wjg.14.3306

U. Walter and P. Santamaria, CD8+ T cells in autoimmunity, Current Opinion in Immunology, vol.17, issue.6, pp.624-655, 2005.
DOI : 10.1016/j.coi.2005.09.014

A. Bendelac, C. Carnaud, C. Boitard, and J. Bach, Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells, Journal of Experimental Medicine, vol.166, issue.4, pp.823-855, 1987.
DOI : 10.1084/jem.166.4.823

T. Dilorenzo and D. Serreze, The good turned ugly: immunopathogenic basis for diabetogenic CD8+ T cells in NOD mice, Immunological Reviews, vol.52, issue.1, pp.250-63, 2005.
DOI : 10.1016/S0168-8227(00)00225-4

M. Longhi, M. Hussain, D. Bogdanos, A. Quaglia, G. Mieli-vergani et al., Cytochrome P450IID6-specific CD8 T cell immune responses mirror disease activity in autoimmune hepatitis type 2, Hepatology, vol.46, issue.2, pp.472-84, 2007.
DOI : 10.1002/hep.21658

J. Russell, G. Morrissette, M. Weidner, C. Vyas, D. Aleman-hoey et al., T Cells Triggered by High Affinity Peptide Antigens, The Journal of Experimental Medicine, vol.4, issue.6, pp.1147-57, 1998.
DOI : 10.1038/ng1195-294

A. Tanaka, S. Iwabuchi, M. Takatori, A. Ohno, H. Yamada et al., Clonotypic analysis of T cells in patients with autoimmune and viral hepatitis, Hepatology, vol.25, issue.5, pp.1070-1076, 1997.
DOI : 10.1002/hep.510250504

H. Dong, G. Zhu, K. Tamada, D. Flies, J. Van-deursen et al., B7-H1 Determines Accumulation and Deletion of Intrahepatic CD8+ T Lymphocytes, Immunity, vol.20, issue.3, pp.327-363, 2004.
DOI : 10.1016/S1074-7613(04)00050-0

J. Lohr, B. Knoechel, and A. Abbas, Regulatory T cells in the periphery, Immunological Reviews, vol.171, issue.1, pp.149-62, 2006.
DOI : 10.1016/j.immuni.2004.07.009

M. Hardtke-wolenski and E. Jaeckel, Mouse Models for Experimental Autoimmune Hepatitis: Limits and Chances, Digestive Diseases, vol.28, issue.1, pp.70-79, 2010.
DOI : 10.1159/000282067

P. Bertolino, A. Schrage, D. Bowen, K. Klugewitz, S. Ghani et al., T cells is predominantly ICAM-1/LFA-1 dependent in mice, Hepatology, vol.11, issue.5, pp.1063-71, 2005.
DOI : 10.1002/hep.20885

J. Buxbaum, P. Qian, P. Allen, and M. Peters, Hepatitis resulting from liver-specific expression and recognition of self-antigen, Journal of Autoimmunity, vol.31, issue.3, pp.208-223, 2008.
DOI : 10.1016/j.jaut.2008.04.015

P. Bertolino, M. Trescol-biemont, and C. Rabourdin-combe, Hepatocytes induce functional activation of naive CD8+ T lymphocytes but fail to promote survival, European Journal of Immunology, vol.34, issue.1, pp.221-257, 1998.
DOI : 10.1002/(SICI)1521-4141(199801)28:01<221::AID-IMMU221>3.0.CO;2-F

C. Ohlen, M. Kalos, L. Cheng, A. Shur, D. Hong et al., CD8(þ) T cell tolerance to a tumor-associated antigen is maintained at the level of expansion rather than effector function, J Exp Med, vol.195, 2002.

D. Voehringer, C. Blaser, A. Grawitz, F. Chisari, K. Buerki et al., Break of T Cell Ignorance to a Viral Antigen in the Liver Induces Hepatitis, The Journal of Immunology, vol.165, issue.5, pp.2415-2437, 2000.
DOI : 10.4049/jimmunol.165.5.2415

M. Zierden, E. Kuhnen, M. Odenthal, and H. Dienes, Effects and Regulation of Autoreactive CD8+ T Cells in a Transgenic Mouse Model of Autoimmune Hepatitis, Gastroenterology, vol.139, issue.3, pp.975-86, 2010.
DOI : 10.1053/j.gastro.2010.05.075

H. Lewicki, A. Tishon, P. Borrow, C. Evans, J. Gairin et al., CTL Escape Viral Variants, Virology, vol.210, issue.1, pp.29-40, 1995.
DOI : 10.1006/viro.1995.1314

URL : http://doi.org/10.1006/viro.1995.1426

F. Baker, M. Lee, Y. Chien, and M. Davis, Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice, Proceedings of the National Academy of Sciences, vol.99, issue.14, pp.9374-9383, 2002.
DOI : 10.1073/pnas.142284899

V. Kouskoff, K. Signorelli, C. Benoist, and D. Mathis, Cassette vectors directing expression of T cell receptor genes in transgenic mice, Journal of Immunological Methods, vol.180, issue.2, pp.273-80, 1995.
DOI : 10.1016/0022-1759(95)00002-R

I. Djilali-saiah, P. Lapierre, S. Vittozi, and F. Alvarez, DNA Vaccination Breaks Tolerance for a Neo-Self Antigen in Liver: A Transgenic Murine Model of Autoimmune Hepatitis, The Journal of Immunology, vol.169, issue.9, pp.4889-96, 2002.
DOI : 10.4049/jimmunol.169.9.4889

P. Lacasse, J. Denis, R. Lapointe, D. Leclerc, and A. Lamarre, Novel Plant Virus-Based Vaccine Induces Protective Cytotoxic T-Lymphocyte-Mediated Antiviral Immunity through Dendritic Cell Maturation, Journal of Virology, vol.82, issue.2, pp.785-94, 2008.
DOI : 10.1128/JVI.01811-07

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2224570

P. Lapierre, K. Beland, I. Djilali-saiah, and F. Alvarez, Type 2 autoimmune hepatitis murine model: The influence of genetic background in disease development, Journal of Autoimmunity, vol.26, issue.2, pp.82-91, 2006.
DOI : 10.1016/j.jaut.2005.11.001

M. Betts, J. Brenchley, D. Price, D. Rosa, S. Douek et al., Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation, Journal of Immunological Methods, vol.281, issue.1-2, pp.65-78, 2003.
DOI : 10.1016/S0022-1759(03)00265-5

L. Walker and A. Abbas, THE ENEMY WITHIN: KEEPING SELF-REACTIVE T CELLS AT BAY IN THE PERIPHERY, Nature Reviews Immunology, vol.166, issue.1, pp.11-20, 2002.
DOI : 10.1084/JEM.194.4.427

B. Han, P. Serra, J. Yamanouchi, A. Amrani, J. Elliott et al., Developmental control of CD8+ T cell???avidity maturation in autoimmune diabetes, Journal of Clinical Investigation, vol.115, issue.7, pp.1879-87, 2005.
DOI : 10.1172/JCI24219

A. Perchellet, I. Stromnes, J. Pang, and J. Goverman, CD8+ T cells maintain tolerance to myelin basic protein by 'epitope theft', Nature Immunology, vol.170, issue.6, pp.606-620, 2004.
DOI : 10.1016/0022-1759(95)00124-S

I. Crispe, Hepatic T cells and liver tolerance, Nature Reviews Immunology, vol.3, issue.1, pp.51-62, 2003.
DOI : 10.1038/nri981

F. Miyagawa, J. Gutermuth, H. Zhang, and S. Katz, The use of mouse models to better understand mechanisms of autoimmunity and tolerance, Journal of Autoimmunity, vol.35, issue.3, pp.192-200, 2010.
DOI : 10.1016/j.jaut.2010.06.007

Y. Oo, C. Weston, P. Lalor, S. Curbishley, D. Withers et al., Distinct Roles for CCR4 and CXCR3 in the Recruitment and Positioning of Regulatory T Cells in the Inflamed Human Liver, The Journal of Immunology, vol.184, issue.6, pp.2886-98, 2010.
DOI : 10.4049/jimmunol.0901216

C. Haluszczak, A. Akue, S. Hamilton, L. Johnson, L. Pujanauski et al., T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion, The Journal of Experimental Medicine, vol.6, issue.2, pp.435-483, 2009.
DOI : 10.1084/jem.20070176

L. Holz, V. Benseler, D. Bowen, P. Bouillet, A. Strasser et al., Intrahepatic Murine CD8 T-Cell Activation Associates With a Distinct Phenotype Leading to Bim-Dependent Death, Gastroenterology, vol.135, issue.3, pp.989-97, 2008.
DOI : 10.1053/j.gastro.2008.05.078

V. Benseler, A. Warren, M. Vo, L. Holz, S. Tay et al., Hepatocyte entry leads to degradation of autoreactive CD8 T cells, Proceedings of the National Academy of Sciences, vol.108, issue.40, pp.16735-16775, 2011.
DOI : 10.1073/pnas.1112251108

D. Vergani, F. Alvarez, F. Bianchi, E. Cancado, I. Mackay et al., Liver autoimmune serology: a consensus statement from the committee for autoimmune serology of the International Autoimmune Hepatitis Group, Journal of Hepatology, vol.41, issue.4, pp.677-83, 2004.
DOI : 10.1016/j.jhep.2004.08.002

S. Vitozzi, P. Lapierre, I. Djilali-saiah, and F. Alvarez, Autoantibody detection in type 2 autoimmune hepatitis using a chimera recombinant protein, Journal of Immunological Methods, vol.262, issue.1-2, pp.103-113, 2002.
DOI : 10.1016/S0022-1759(02)00016-9

P. Bertolino, G. Mccaughan, and D. Bowen, Role of primary intrahepatic T-cell activation in the 'liver tolerance effect', Immunology and Cell Biology, vol.64, issue.1, pp.84-92, 2002.
DOI : 10.1016/S0168-8278(00)00020-9