Occupational exposure to asbestos and lung cancer in men: evidence from a population-based case-control study in eight Canadian provinces. - Archive ouverte HAL Access content directly
Journal Articles BMC Cancer Year : 2012

Occupational exposure to asbestos and lung cancer in men: evidence from a population-based case-control study in eight Canadian provinces.

(1, 2, 3) , (4) , (2, 3, 5, 6) , (7)
1
2
3
4
5
6
7

Abstract

BACKGROUND: Asbestos is classified as a human carcinogen, and studies have consistently demonstrated that workplace exposure to it increases the risk of developing lung cancer. Few studies have evaluated risks in population-based settings where there is a greater variety in the types of occupations, and exposures. METHODS: This was a population based case-control study with 1,681 incident cases of lung cancer, and 2,053 controls recruited from 8 Canadian provinces between 1994 and 1997. Self-reported questionnaires were used to elicit a lifetime occupational history, including general tasks, and information for other risk factors. Occupational hygienists, who were blinded to case-control status, assigned asbestos exposures to each job on the basis of (i) concentration (low, medium, high), (ii) frequency (<5%, 5-30%, and >30% of the time in a normal work week), and (iii) reliability (possible, probable, definite). Logistic regression was used to estimate odds ratios (ORs) and their corresponding 95% confidence intervals (CI). RESULTS: Those occupationally exposed to (i) low, and (ii) medium or high concentrations of asbestos had ORs for lung cancer of 1.17 (95% CI=0.92 - 1.50) and 2.16 (95% CI=1.21-3.88), respectively, relative to those who were unexposed. Medium or high exposure to asbestos roughly doubled the risk for lung cancer across all three smoking pack-year categories. The joint relationship between smoking and asbestos was consistent with a multiplicative risk model. CONCLUSIONS: Our findings provide further evidence that exposure to asbestos has contributed to an increased risk of lung cancer in Canadian workplaces, and suggests that nearly 3% of lung cancers among Canadian men are caused by occupational exposure to asbestos.
Fichier principal
Vignette du fichier
Parent_M.-E._23234401.pdf (199.51 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

pasteur-01007618 , version 1 (16-06-2014)

Identifiers

Cite

Paul J Villeneuve, Marie-Élise Parent, Shelley A Harris, Kenneth C Johnson. Occupational exposure to asbestos and lung cancer in men: evidence from a population-based case-control study in eight Canadian provinces.. BMC Cancer, 2012, 12, pp.595. ⟨10.1186/1471-2407-12-595⟩. ⟨pasteur-01007618⟩

Collections

RIIP INRS-IAF
144 View
297 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More