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A distinctive role for galectin-7 in cancer ?

Abstract : The galectins are a family of evolutionay-conserved carbohydrate-binding proteins. They are distributed widely in all living organisms and have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis. Several members of the galectin family have also been shown to be involved in cancer progression and metastasis. In the case of galectin-7, several studies have reported alterations in its expression pattern during cancer progression. In a variety of tumors, its expression can range from being completely down-regulated to highly up-regulated. Accordingly, its precise role in this field is still debated. The evidence shows that galectin-7 may promote or inhibit cancer development. In this article, we review the data concerning expression and roles of galectin-7 in cancer and propose a comprehensive view of its contribution during cancer progression.
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Submitted on : Wednesday, June 18, 2014 - 3:53:21 PM
Last modification on : Monday, October 8, 2018 - 5:44:05 PM

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Yves St-Pierre, Carole G Campion, Andree-Anne Grosset. A distinctive role for galectin-7 in cancer ?. Frontiers in Bioscience, Frontiers in Bioscience, 2012, 17, pp.438-50. ⟨10.2741/3937⟩. ⟨pasteur-01009758⟩

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