Skip to Main content Skip to Navigation
Journal articles

A first assessment of Mycobacterium tuberculosis genetic diversity and drug-resistance patterns in twelve Caribbean territories.

Abstract : With the exception of some French-speaking islands, data on tuberculosis (TB) in the Caribbean are scarce. In this study, we report a first assessment of genetic diversity of a convenience sample of Mycobacterium tuberculosis strains received from twelve Caribbean territories by spoligotyping and describe their drug-resistance patterns. Of the 480 isolates, 40 (8.3%) isolates showed resistance to at least one anti-TB drug. The proportion of drug-resistant strains was significantly higher in The Bahamas (21.4%; P = 0.02), and Guyana (27.5%; P < 0.0001), while it was significantly lower in Jamaica (2.4%; P = 0.03) than in other countries of the present study. Regarding genetic diversity, 104 distinct spoligotype patterns were observed: 49 corresponded to clustered strains (2 to 93 strains per cluster), while 55 remained unclustered among which 16 patterns were not reported previously. Combining the study results with regional data retrieved from the international SITVIT2 database underlined a connection between frequency of certain M. tuberculosis phylogenetic lineages and the language spoken, suggesting historical (colonial) and ongoing links (trade, tourism, and migratory flows) with European countries with which they shared a common past.
Document type :
Journal articles
Complete list of metadatas

Cited literature [26 references]  Display  Hide  Download

https://hal-riip.archives-ouvertes.fr/pasteur-01011078
Contributor : Nalin Rastogi <>
Submitted on : Sunday, June 22, 2014 - 10:53:01 PM
Last modification on : Friday, May 29, 2020 - 7:42:02 PM
Long-term archiving on: : Tuesday, April 11, 2017 - 8:07:11 AM

File

2014_BMRI718496_Caribbean.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Julie Millet, Shirematee Baboolal, Elisabeth Streit, Patrick E Akpaka, Nalin Rastogi. A first assessment of Mycobacterium tuberculosis genetic diversity and drug-resistance patterns in twelve Caribbean territories.. BioMed Research International , Hindawi Publishing Corporation, 2014, 2014, Article ID 718496, 11 p. ⟨10.1155/2014/718496⟩. ⟨pasteur-01011078⟩

Share

Metrics

Record views

141

Files downloads

217