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The emm-cluster typing system for group A Streptococcus identifies epidemiologic similarities across the Pacific region.

Abstract : BACKGROUND: Group A Streptococcus (GAS) related disease is responsible for high mortality and morbidity in the Pacific region. The high diversity of circulating strains in this region has hindered vaccine development due to apparently low vaccine coverage of type-specific vaccines. METHOD: Prospective passive surveillance of all GAS isolates in New Caledonia was undertaken in 2012 using emm-typing and emm-cluster typing. Molecular data were compared with the results from a prior study undertaken in the same country and with data from two other pacific countries: Fiji and Australia. RESULTS: A high incidence of invasive infection was demonstrated at 43 cases per 100,000 inhabitants (95% confidence interval 35 - 52). 318 GAS isolates belonging to 47 different emm-types were collected. In Noumea, only 30% of the isolates recovered in 2012 belonged to an emm-type that was present in the same city in 2006 whereas 69% of the isolates collected in 2012 belonged to an emm-cluster present in 2006. When comparing New Caledonian, Australian and Fijian data, very few common emm-types were found but 79 - 86% of the isolates from each country belonged to an emm-cluster present in all three countries. A vaccine that could protect against the 10 most frequent emm-clusters in the Pacific region would potentially provide coverage ranging from 83 to 92%. CONCLUSIONS: This study confirms the high disease burden of GAS infection in New Caledonia and supports the added value of the emm-cluster typing system to analyze GAS epidemiology and to help inform global GAS vaccine formulation.
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https://hal-riip.archives-ouvertes.fr/pasteur-01017695
Contributor : Myrielle Dupont-Rouzeyrol <>
Submitted on : Thursday, July 3, 2014 - 3:08:13 AM
Last modification on : Thursday, June 4, 2020 - 10:24:05 AM

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Noémie Baroux, Eric d'Ortenzio, Nathalie Amédéo, Ciara Baker, Barakat Ali Alsuwayyid, et al.. The emm-cluster typing system for group A Streptococcus identifies epidemiologic similarities across the Pacific region.. Clinical Infectious Diseases, Oxford University Press (OUP), 2014, pp.e1-e9. ⟨10.1093/cid/ciu490⟩. ⟨pasteur-01017695⟩

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