Metal-Based Compounds as Prospective Antileishmanial Agents: Inhibition of Trypanothione Reductase by Selected Gold Complexes. - RIIP - Réseau International des Instituts Pasteur Accéder directement au contenu
Article Dans Une Revue ChemMedChem Année : 2013

Metal-Based Compounds as Prospective Antileishmanial Agents: Inhibition of Trypanothione Reductase by Selected Gold Complexes.

Résumé

: Picking a fight with parasites! Trypanothione reductase (TR) is a validated drug target for the development of antileishmanial agents. A group of structurally diverse gold-containing compounds was evaluated in vitro for TR inhibition. A number of compounds exhibited potent activity and deserve further pharmacological evaluation.
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pasteur-01024027 , version 1 (15-07-2014)

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Gianni Colotti, Andrea Ilari, Annarita Fiorillo, Paola Baiocco, Maria Agostina Cinellu, et al.. Metal-Based Compounds as Prospective Antileishmanial Agents: Inhibition of Trypanothione Reductase by Selected Gold Complexes.. ChemMedChem, 2013, epub ahead of print. ⟨10.1002/cmdc.201300276⟩. ⟨pasteur-01024027⟩

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