N. Borley and M. R. Feneley, Prostate cancer: diagnosis and staging, Asian Journal of Andrology, vol.11, issue.1, pp.74-80, 2009.
DOI : 10.1038/aja.2008.19

N. N. Tadros and M. Garzotto, Androgen deprivation therapy for prostate cancer: not so simple, Asian Journal of Andrology, vol.13, issue.2, pp.187-188, 2011.
DOI : 10.1038/aja.2010.174

L. Boccon-gibod, E. Van-der-meulen, and B. E. Persson, An update on the use of gonadotropin-releasing hormone antagonists in prostate cancer, Therapeutic Advances in Urology, vol.54, issue.3, pp.127-140, 2011.
DOI : 10.1177/1756287211414457

S. Oudard, Progress in emerging therapies for advanced prostate cancer, Cancer Treatment Reviews, vol.39, issue.3, pp.275-289, 2013.
DOI : 10.1016/j.ctrv.2012.09.005

D. L. Hess, C. C. Nelson, and A. M. Matsumoto, Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: Therapeutic implications for castration-resistant prostate cancer, Cancer Res, vol.67, pp.5033-5041, 2007.

P. Saraon, K. Jarvi, and E. P. Diamandis, Molecular Alterations during Progression of Prostate Cancer to Androgen Independence, Clinical Chemistry, vol.57, issue.10, pp.1366-1375, 2011.
DOI : 10.1373/clinchem.2011.165977

K. E. Knudsen and H. Scher, Starving the Addiction: New Opportunities for Durable Suppression of AR Signaling in Prostate Cancer, Clinical Cancer Research, vol.15, issue.15, pp.4792-4798, 2009.
DOI : 10.1158/1078-0432.CCR-08-2660

H. Miyake, C. Nelson, P. S. Rennie, and M. E. Gleave, Overexpression of Insulin-Like Growth Factor Binding Protein-5 Helps Accelerate Progression to Androgen-Independence in the Human Prostate LNCaP Tumor Model through Activation of Phosphatidylinositol 3'-Kinase Pathway, Endocrinology, vol.141, issue.6, pp.2257-2265, 2000.
DOI : 10.1210/en.141.6.2257

P. Rocchi, A. So, S. Kojima, M. Signaevsky, E. Beraldi et al., Heat Shock Protein 27 Increases after Androgen Ablation and Plays a Cytoprotective Role in Hormone-Refractory Prostate Cancer, Cancer Research, vol.64, issue.18, pp.6595-6602, 2004.
DOI : 10.1158/0008-5472.CAN-03-3998

B. Levine and D. J. Klionsky, Development by Self-Digestion, Developmental Cell, vol.6, issue.4, pp.463-477, 2004.
DOI : 10.1016/S1534-5807(04)00099-1

D. Glick, S. Barth, and K. F. Macleod, Autophagy: cellular and molecular mechanisms, The Journal of Pathology, vol.21, issue.1, pp.3-12, 2010.
DOI : 10.1002/path.2697

T. Shintani and D. J. Klionsky, Autophagy in Health and Disease: A Double-Edged Sword, Science, vol.306, issue.5698, pp.990-995, 2004.
DOI : 10.1126/science.1099993

C. Horbinski, C. Mojesky, and N. Kyprianou, Live Free or Die, The American Journal of Pathology, vol.177, issue.3, pp.1044-1052, 2010.
DOI : 10.2353/ajpath.2010.091270

E. A. Corcelle, P. Puustinen, and M. Jaattela, Apoptosis and autophagy: Targeting autophagy signalling in cancer cells -???trick or treats????, FEBS Journal, vol.5, issue.2 Pt 1, pp.6084-6096, 2009.
DOI : 10.1111/j.1742-4658.2009.07332.x

M. M. Hippert, P. S. O-'toole, and A. Thorburn, Autophagy in cancer: Good, bad, or both? Cancer Res, pp.9349-9351, 2006.

Y. Kondo, T. Kanzawa, R. Sawaya, and S. Kondo, The role of autophagy in cancer development and response to therapy, Nature Reviews Cancer, vol.335, issue.4, pp.726-734, 2005.
DOI : 10.1016/0014-4800(90)90061-H

S. Arico, A. Petiot, C. Bauvy, P. F. Dubbelhuis, A. J. Meijer et al., The Tumor Suppressor PTEN Positively Regulates Macroautophagy by Inhibiting the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway, Journal of Biological Chemistry, vol.276, issue.38, pp.35243-35246, 2001.
DOI : 10.1074/jbc.C100319200

S. Pattingre, A. Tassa, X. Qu, R. Garuti, X. H. Liang et al., Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy, Cell, vol.122, issue.6, pp.927-939, 2005.
DOI : 10.1016/j.cell.2005.07.002

L. Li, G. Ishdorj, and S. B. Gibson, Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment, Free Radical Biology and Medicine, vol.53, issue.7, pp.1399-1410, 2012.
DOI : 10.1016/j.freeradbiomed.2012.07.011

A. L. Edinger and C. B. Thompson, Defective autophagy leads to cancer, Cancer Cell, vol.4, issue.6, pp.422-424, 2003.
DOI : 10.1016/S1535-6108(03)00306-4

V. M. Aita, X. H. Liang, V. V. Murty, D. L. Pincus, W. Yu et al., Cloning and Genomic Organization of Beclin 1, a Candidate Tumor Suppressor Gene on Chromosome 17q21, Genomics, vol.59, issue.1, pp.59-65, 1999.
DOI : 10.1006/geno.1999.5851

X. Qu, J. Yu, G. Bhagat, N. Furuya, H. Hibshoosh et al., Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene, Journal of Clinical Investigation, vol.112, issue.12, pp.1809-1820, 2003.
DOI : 10.1172/JCI20039DS1

K. N. Dalby, I. Tekedereli, G. Lopez-berestein, and B. Ozpolat, Targeting the pro-death and pro-survival functions of autophagy as novel therapeutic strategies in cancer, Autophagy, vol.6, issue.3, pp.322-329, 2010.
DOI : 10.4161/auto.6.3.11625

H. J. Kung, Targeting Tyrosine Kinases and Autophagy in Prostate Cancer, Hormones and Cancer, vol.119, issue.5, pp.38-46, 2011.
DOI : 10.1007/s12672-010-0053-3

Z. Guo, B. Dai, T. Jiang, K. Xu, Y. Xie et al., Regulation of androgen receptor activity by tyrosine phosphorylation, Cancer Cell, vol.10, issue.4, pp.309-319, 2006.
DOI : 10.1016/j.ccr.2006.08.021

S. H. Lo and C. P. Evans, Autophagy blockade sensitizes prostate cancer cells towards Src family kinase inhibitors, Genes Cancer, vol.1, pp.40-49, 2010.

M. L. Bristol, S. M. Emery, P. Maycotte, A. Thorburn, S. Chakradeo et al., Autophagy Inhibition for Chemosensitization and Radiosensitization in Cancer: Do the Preclinical Data Support This Therapeutic Strategy?, Journal of Pharmacology and Experimental Therapeutics, vol.344, issue.3, pp.544-552, 2013.
DOI : 10.1124/jpet.112.199802

M. Kumano, J. Furukawa, M. Shiota, A. Zardan, F. Zhang et al., Cotargeting Stress-Activated Hsp27 and Autophagy as a Combinatorial Strategy to Amplify Endoplasmic Reticular Stress in Prostate Cancer, Molecular Cancer Therapeutics, vol.11, issue.8, pp.1661-1671, 2012.
DOI : 10.1158/1535-7163.MCT-12-0072

F. Lamoureux, C. Thomas, C. Crafter, M. Kumano, F. Zhang et al., Blocked Autophagy Using Lysosomotropic Agents Sensitizes Resistant Prostate Tumor Cells to the Novel Akt Inhibitor AZD5363, Clinical Cancer Research, vol.19, issue.4, pp.833-844
DOI : 10.1158/1078-0432.CCR-12-3114

L. Yu, V. Tumati, S. F. Tseng, F. M. Hsu, D. N. Kim et al., DAB2IP Regulates Autophagy in Prostate Cancer in Response to Combined Treatment of Radiation and a DNA-PKcs Inhibitor, Neoplasia, vol.14, issue.12, pp.1203-1212, 2012.
DOI : 10.1593/neo.121310

R. J. Chen, C. M. Hung, Y. L. Chen, M. D. Wu, G. F. Yuan et al., Monascuspiloin Induces Apoptosis and Autophagic Cell Death in Human Prostate Cancer Cells via the Akt and AMPK Signaling Pathways, Journal of Agricultural and Food Chemistry, vol.60, issue.29, pp.7185-7193
DOI : 10.1021/jf3016927

S. Tai, Y. Sun, N. Liu, B. Ding, E. Hsia et al., Combination of Rad001 (Everolimus) and Propachlor Synergistically Induces Apoptosis through Enhanced Autophagy in Prostate Cancer Cells, Molecular Cancer Therapeutics, vol.11, issue.6, pp.1320-1331, 2012.
DOI : 10.1158/1535-7163.MCT-11-0954

Z. He, L. S. Mangala, C. A. Theriot, L. H. Rohde, H. Wu et al., Cell Killing and Radiosensitizing Effects of Atorvastatin in PC3 Prostate Cancer Cells, Journal of Radiation Research, vol.53, issue.2, pp.225-233, 2012.
DOI : 10.1269/jrr.11114

R. K. Jain, N. Safabakhsh, A. Sckell, Y. Chen, P. Jiang et al., Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: Role of vascular endothelial growth factor, Proc. Natl. Acad. Sci, pp.10820-10825, 1998.
DOI : 10.1073/pnas.95.18.10820

R. R. Chhipa, Y. Wu, and C. Ip, AMPK-mediated autophagy is a survival mechanism in androgen-dependent prostate cancer cells subjected to androgen deprivation and hypoxia, Cellular Signalling, vol.23, issue.9, pp.1466-1472, 2011.
DOI : 10.1016/j.cellsig.2011.04.008

R. R. Kaini and C. A. Hu, Synergistic killing effect of chloroquine and androgen deprivation in LNCaP cells, Biochemical and Biophysical Research Communications, vol.425, issue.2, pp.150-156, 2012.
DOI : 10.1016/j.bbrc.2012.07.054

R. R. Chhipa, Y. Wu, J. L. Mohler, and C. Ip, Survival advantage of AMPK activation to androgen-independent prostate cancer cells during energy stress, Cellular Signalling, vol.22, issue.10, pp.1554-1561, 2010.
DOI : 10.1016/j.cellsig.2010.05.024

A. J. Meijer and P. Codogno, AMP-Activated Protein Kinase and Autophagy, Autophagy, vol.3, issue.3, pp.238-240, 2007.
DOI : 10.4161/auto.3710

URL : https://hal.archives-ouvertes.fr/inserm-00175293

H. U. Park, S. Suy, M. Danner, V. Dailey, Y. Zhang et al., AMP-activated protein kinase promotes human prostate cancer cell growth and survival, Molecular Cancer Therapeutics, vol.8, issue.4, pp.733-741, 2009.
DOI : 10.1158/1535-7163.MCT-08-0631

P. V. Schoenlein, S. Periyasamy-thandavan, J. S. Samaddar, W. H. Jackson, and J. Barrett, Autophagy facilitates the progression of ER??-positive breast cancer cells to antiestrogen resistance, Autophagy, vol.5, issue.3, pp.400-403, 2009.
DOI : 10.4161/auto.5.3.7784

H. L. Bennett, J. Stockley, J. T. Fleming, R. Mandal, J. O-'prey et al., Does androgen-ablation therapy (AAT) associated autophagy have a pro-survival effect in LNCaP human prostate cancer cells? BJU Int, pp.672-682, 2012.

C. A. Homewood, D. C. Warhurst, W. Peters, and V. C. Baggaley, Lysosomes, pH and the Anti-malarial Action of Chloroquine, Nature, vol.3, issue.5332, pp.50-52, 1972.
DOI : 10.1038/235050a0

J. Sotelo, E. Briceno, and M. A. Lopez-gonzalez, Adding Chloroquine to Conventional Treatment for Glioblastoma Multiforme, Annals of Internal Medicine, vol.144, issue.5, pp.337-343, 2006.
DOI : 10.7326/0003-4819-144-5-200603070-00008

H. Cheong, C. Lu, T. Lindsten, and C. B. Thompson, Therapeutic targets in cancer cell metabolism and autophagy, Nature Biotechnology, vol.5, issue.7, pp.671-678, 2012.
DOI : 10.1038/nbt.2285

D. G. Tang and A. Porter, Target to apoptosis: A hopeful weapon for prostate cancer, The Prostate, vol.224, issue.4, pp.284-293, 1997.
DOI : 10.1002/(SICI)1097-0045(19970901)32:4<284::AID-PROS9>3.0.CO;2-J

V. Hesry, C. Piquet-pellorce, M. Travert, L. Donaghy, B. Jegou et al., Sensitivity of prostate cells to TRAIL-induced apoptosis increases with tumor progression: DR5 and caspase 8 are key players, Prostate, vol.66, pp.987-995, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00684995

Y. Nakajima, A. M. Dellipizzi, C. Mallouh, and N. R. Ferreri, TNF-mediated cytotoxicity and resistance in human prostate cancer cell lines, The Prostate, vol.58, issue.5, pp.296-302, 1996.
DOI : 10.1002/(SICI)1097-0045(199611)29:5<296::AID-PROS4>3.0.CO;2-8

D. 'arcangelo, D. Giampietri, C. Facchiano, F. Facchiano, and A. , BAMM: a preliminary Bibliometric Analysis on Melanoma Manuscripts, Pigment Cell & Melanoma Research, vol.20, issue.3, pp.415-417, 2013.
DOI : 10.1111/pcmr.12079

C. Giampietri, S. Petrungaro, A. Facchiano, A. Filippini, and E. Ziparo, Therapeutic implications of autophagy modulation in prostate cancer, Journal of Endocrinological Investigation, vol.109, issue.10, p.945, 2012.
DOI : 10.1007/BF03346738

C. Giampietri, S. Petrungaro, F. Padula, A. D-'alessio, E. S. Marini et al., Autophagy modulators sensitize prostate epithelial cancer cell lines to TNF-alpha-dependent apoptosis, Apoptosis, vol.3, issue.11, pp.1210-1222, 2012.
DOI : 10.1007/s10495-012-0752-z

URL : https://hal.archives-ouvertes.fr/pasteur-00966430

W. He, Q. Wang, J. Xu, X. Xu, M. T. Padilla et al., Attenuation of TNFSF10/TRAIL-induced apoptosis by an autophagic survival pathway involving TRAF2- and RIPK1/RIP1-mediated MAPK8/JNK activation, Autophagy, vol.15, issue.12, pp.1811-1821, 2012.
DOI : 10.1016/S1074-7613(00)80194-6

K. Zhu, K. Dunner, . Jr, and D. J. Mcconkey, Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells, Oncogene, vol.3, issue.3, pp.451-462, 2010.
DOI : 10.1158/0008-5472.CAN-08-4103

J. Y. Lee, H. Koga, Y. Kawaguchi, W. X. Tang, E. Wong et al., HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy, The EMBO Journal, vol.390, issue.5, pp.969-980, 2010.
DOI : 10.1016/j.molcel.2007.05.033

O. True and P. Matthias, Interplay between histone deacetylases and autophagy - from cancer therapy to neurodegeneration, Immunology and Cell Biology, vol.71, issue.1, pp.78-84, 2012.
DOI : 10.1073/pnas.0907935106

J. V. Lu and C. M. Walsh, Programmed necrosis and autophagy in immune function, Immunological Reviews, vol.13, issue.1, pp.205-217, 2012.
DOI : 10.1111/j.1600-065X.2012.01147.x

G. Muzes and F. Sipos, Anti-tumor immunity, autophagy and chemotherapy, World Journal of Gastroenterology, vol.18, issue.45, pp.6537-6540
DOI : 10.3748/wjg.v18.i45.6537

D. C. Palmer, C. E. Touloukian, and K. Ptak, Tumor-specific Th17-polarized cells eradicate large established melanoma, Blood, vol.112, pp.362-373, 2008.

G. O. Ahn, D. Tseng, C. H. Liao, M. J. Dorie, A. Czechowicz et al., Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment, Proc. Natl. Acad. Sci. USA 2010, pp.8363-8368
DOI : 10.1073/pnas.0911378107

M. E. Wildenberg, A. C. Vos, S. C. Wolfkamp, M. Duijvestein, A. P. Verhaar et al., Autophagy Attenuates the Adaptive Immune Response by Destabilizing the Immunologic Synapse, Gastroenterology, vol.142, issue.7, pp.1493-1503, 2012.
DOI : 10.1053/j.gastro.2012.02.034

D. A. Barron and D. R. Rowley, The reactive stroma microenvironment and prostate cancer progression, Endocrine Related Cancer, vol.19, issue.6, pp.187-204
DOI : 10.1530/ERC-12-0085

M. J. Gerdes, T. D. Dang, M. Larsen, and D. R. Rowley, Transforming growth factor-beta1 induces nuclear to cytoplasmic distribution of androgen receptor and inhibits androgen response in prostate smooth muscle cells, Endocrinology, vol.139, pp.3569-3577, 1998.

E. Jones, H. Pu, and N. Kyprianou, Targeting TGF-?? in prostate cancer: therapeutic possibilities during tumor progression, Expert Opinion on Therapeutic Targets, vol.105, issue.2, pp.227-234, 2009.
DOI : 10.1016/S0076-6879(04)92023-X

S. N. Salm, P. E. Burger, S. Coetzee, K. Goto, D. Moscatelli et al., TGF-?? maintains dormancy of prostatic stem cells in the proximal region of ducts, The Journal of Cell Biology, vol.157, issue.1, pp.81-90, 2005.
DOI : 10.1002/(SICI)1097-0045(19990301)38:4<268::AID-PROS2>3.0.CO;2-4

D. G. Stover, B. Bierie, and H. L. Moses, A delicate balance: TGF-?? and the tumor microenvironment, Journal of Cellular Biochemistry, vol.14, issue.4, pp.851-861, 2007.
DOI : 10.1002/jcb.21149

B. Zhu and N. Kyprianou, Transforming Growth Factor Beta and Prostate Cancer, Cancer Treat. Res, vol.126, pp.157-173, 2005.
DOI : 10.1007/0-387-24361-5_7

P. Alonso-magdalena, C. Brossner, A. Reiner, G. Cheng, N. Sugiyama et al., A role for epithelial-mesenchymal transition in the etiology of benign prostatic hyperplasia, Proc. Natl. Acad. Sci. USA 2009, pp.2859-2863
DOI : 10.1073/pnas.0812666106

M. Ao, O. E. Franco, D. Park, D. Raman, K. Williams et al., Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium. Cancer Res, pp.4244-4253, 2007.

P. H. Gann, K. G. Klein, R. T. Chatterton, A. E. Ellman, J. T. Grayhack et al., Growth factors in expressed prostatic fluid from men with prostate cancer, BPH, and clinically normal prostates, The Prostate, vol.33, issue.4, pp.248-255, 1999.
DOI : 10.1002/(SICI)1097-0045(19990901)40:4<248::AID-PROS6>3.0.CO;2-M

D. A. Shoskes, Q. Albakri, K. Thomas, and D. Cook, Cytokine Polymorphisms in Men with Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Association with Diagnosis and Treatment Response, The Journal of Urology, vol.168, issue.1, pp.331-335, 2002.
DOI : 10.1016/S0022-5347(05)64916-6

K. Kiyono, H. I. Suzuki, H. Matsuyama, Y. Morishita, A. Komuro et al., Autophagy Is Activated by TGF-?? and Potentiates TGF-??-Mediated Growth Inhibition in Human Hepatocellular Carcinoma Cells, Cancer Research, vol.69, issue.23, pp.8844-8852, 2009.
DOI : 10.1158/0008-5472.CAN-08-4401

C. Lee, S. M. Sintich, E. P. Mathews, A. H. Shah, S. D. Kundu et al., Transforming growth factor-? in benign and malignant prostate, The Prostate, vol.16, issue.4, pp.285-290, 1999.
DOI : 10.1002/(SICI)1097-0045(19990601)39:4<285::AID-PROS9>3.0.CO;2-7

A. R. Reynolds and N. Kyprianou, Growth factor signalling in prostatic growth: significance in tumour development and therapeutic targeting, British Journal of Pharmacology, vol.85, issue.S2, pp.144-152, 2006.
DOI : 10.1038/sj.bjp.0706635

P. Fuzio, P. Ditonno, M. Rutigliano, M. Battaglia, C. Bettocchi et al., Regulation of TGF-beta1 expression by androgen deprivation therapy of prostate cancer. Cancer Lett, pp.135-144, 2012.

I. Calone and S. Souchelnytskyi, Inhibition of TGFbeta signaling and its implications in anticancer treatments, Exp. Oncol, vol.34, pp.9-16, 2012.

Y. Mirochnik, D. Veliceasa, L. Williams, K. Maxwell, A. Yemelyanov et al., Androgen receptor drives cellular senescence. PLoS One, 2012.

E. White and S. W. Lowe, Eating to exit: autophagy-enabled senescence revealed, Genes & Development, vol.23, issue.7, pp.784-787, 2009.
DOI : 10.1101/gad.1795309