Tyrosinase and Layer-by-Layer supported tyrosinases in the synthesis of lipophilic catechols with antiinfluenza activity. - Archive ouverte HAL Access content directly
Journal Articles Bioorganic and Medicinal Chemistry Year : 2013

Tyrosinase and Layer-by-Layer supported tyrosinases in the synthesis of lipophilic catechols with antiinfluenza activity.

(1) , (1) , (1) , (1) , (1) , (2) , (3) , (2) , (2, 3)
1
2
3

Abstract

Catechol derivatives with lipophilic properties have been selectively synthesized by tyrosinase in high yield avoiding long and tedious protection/deprotection steps usually required in traditional procedures. The synthesis was effective also with immobilized tyrosinase able to perform for more runs. The novel catechols were evaluated against influenza A virus, that continue to represent a severe threat worldwide. A significant antiviral activity was observed in derivatives characterized by antioxidant activity and long carbon alkyl side-chains, suggesting the possibility of a new inhibition mechanism based on both redox and lipophilic properties.
Embargoed file
Embargoed file
Ne sera jamais visible
Loading...

Dates and versions

pasteur-01049065 , version 1 (25-07-2014)

Identifiers

Cite

Tiziana Bozzini, Giorgia Botta, Michela Delfino, Silvano Onofri, Raffaele Saladino, et al.. Tyrosinase and Layer-by-Layer supported tyrosinases in the synthesis of lipophilic catechols with antiinfluenza activity.. Bioorganic and Medicinal Chemistry, 2013, 21 (24), pp.7699-708. ⟨10.1016/j.bmc.2013.10.026⟩. ⟨pasteur-01049065⟩

Collections

RIIP RIIP_FCB
14 View
1 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More