L. Saunders and E. Verdin, Sirtuins: critical regulators at the crossroads between cancer and aging, Oncogene, vol.11, issue.37, pp.5489-5504, 2007.
DOI : 10.1016/S1097-2765(02)00477-X

A. Vaquero, The conserved role of sirtuins in chromatin regulation, The International Journal of Developmental Biology, vol.53, issue.2-3, pp.303-322, 2009.
DOI : 10.1387/ijdb.082675av

X. Li, SIRT1 and energy metabolism, Acta Biochimica et Biophysica Sinica, vol.45, issue.1, 2013.
DOI : 10.1093/abbs/gms108

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527007

E. Michishita, R. Mccord, E. Berber, M. Kioi, and H. Padilla-nash, SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin, Nature, vol.273, issue.7186, pp.492-496, 2008.
DOI : 10.1038/nature06736

A. Sauve, C. Wolberger, V. Schramm, and J. Boeke, The Biochemistry of Sirtuins, Annual Review of Biochemistry, vol.75, issue.1, pp.435-465, 2006.
DOI : 10.1146/annurev.biochem.74.082803.133500

M. Barber, E. Michishita-kioi, Y. Xi, L. Tasselli, and M. Kioi, SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation, Nature, vol.35, pp.114-118, 2012.
DOI : 10.1038/nature11043

K. Tanner, J. Landry, R. Sternglanz, and J. Denu, Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose, Proceedings of the National Academy of Sciences, vol.97, issue.26, pp.14178-14182, 2000.
DOI : 10.1073/pnas.250422697

Y. Fang and M. Nicholl, Sirtuin 1 in malignant transformation: Friend or foe?, Cancer Letters, vol.306, issue.1, 2011.
DOI : 10.1016/j.canlet.2011.02.019

O. Grubisha, B. Smith, and J. Denu, Small molecule regulation of Sir2 protein deacetylases, FEBS Journal, vol.120, issue.18, pp.4607-4616, 2005.
DOI : 10.1038/nature02789

J. Villalba and F. Alcaín, Sirtuin activators and inhibitors, BioFactors, vol.28, issue.5, pp.349-359, 2012.
DOI : 10.1002/biof.1032

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467333

S. Michan and D. Sinclair, Sirtuins in mammals: insights into their biological function, Biochemical Journal, vol.404, issue.1, 2007.
DOI : 10.1042/BJ20070140

S. Imai and L. Guarente, Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases, Trends in Pharmacological Sciences, vol.31, issue.5, p.20226541, 2010.
DOI : 10.1016/j.tips.2010.02.003

K. Howitz, K. Bitterman, H. Cohen, D. Lamming, and S. Lavu, Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan, Nature, vol.425, issue.6954, p.12939617, 2003.
DOI : 10.1038/nature01960

S. Forsburg, The art and design of genetic screens, Yeast -Nat Rev Genet, vol.2, 2001.

M. Grunstein, Molecular model for telomeric heterochromatin in yeast, Current Opinion in Cell Biology, vol.9, issue.3, pp.383-38780011, 1997.
DOI : 10.1016/S0955-0674(97)80011-7

J. Sherman, E. Stone, L. Freeman-cook, C. Brachmann, and J. Boeke, The Conserved Core of a Human SIR2 Homologue Functions in Yeast Silencing, Molecular Biology of the Cell, vol.10, issue.9, 1999.
DOI : 10.1091/mbc.10.9.3045

S. Perrod, M. Cockell, T. Laroche, H. Renauld, and A. Ducrest, A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast, The EMBO Journal, vol.20, issue.1, 2001.
DOI : 10.1093/emboj/20.1.197

A. Brunet, L. Sweeney, J. Sturgill, K. Chua, and P. Greer, Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase, Science, vol.303, issue.5666, 2004.
DOI : 10.1126/science.1094637

O. Aparicio, B. Billington, and D. Gottschling, Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae, Cell, vol.66, issue.6, pp.1279-128710, 1991.
DOI : 10.1016/0092-8674(91)90049-5

M. Bryk, M. Banerjee, M. Murphy, K. Knudsen, and D. Garfinkel, Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast., Genes & Development, vol.11, issue.2, p.9009207, 1997.
DOI : 10.1101/gad.11.2.255

E. Smith and A. Shilatifard, The A, B, Gs of silencing, Genes & Development, vol.21, issue.10, pp.1141-1144, 2007.
DOI : 10.1101/gad.1559407

S. Gottlieb and R. Esposito, A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA, Cell, vol.56, issue.5, pp.771-77610, 1989.
DOI : 10.1016/0092-8674(89)90681-8

D. Robyr, Y. Suka, I. Xenarios, S. Kurdistani, and A. Wang, Microarray Deacetylation Maps Determine Genome-Wide Functions for Yeast Histone Deacetylases, Cell, vol.109, issue.4, pp.437-44610, 2002.
DOI : 10.1016/S0092-8674(02)00746-8

G. Santangelo, J. Tornow, C. Mclaughlin, and K. Moldave, Properties of promoters cloned randomly from the Saccharomyces cerevisiae genome., Molecular and Cellular Biology, vol.8, issue.10, pp.4217-4224, 1988.
DOI : 10.1128/MCB.8.10.4217

T. Kobayashi and A. Ganley, Recombination Regulation by Transcription-Induced Cohesin Dissociation in rDNA Repeats, Science, vol.309, issue.5740, pp.1581-1584, 2005.
DOI : 10.1126/science.1116102

C. Li, J. Mueller, and M. Bryk, Sir2 Represses Endogenous Polymerase II Transcription Units in the Ribosomal DNA Nontranscribed Spacer, Molecular Biology of the Cell, vol.17, issue.9, pp.3848-3859, 2006.
DOI : 10.1091/mbc.E06-03-0205

S. Ehrentraut, J. Weber, J. Dybowski, D. Hoffmann, and A. Ehrenhofer-murray, Rpd3-dependent boundary formation at telomeres by removal of Sir2 substrate, Proceedings of the National Academy of Sciences, vol.107, issue.12, pp.5522-5527, 2010.
DOI : 10.1073/pnas.0909169107

M. Matecic, K. Martins-taylor, M. Hickman, T. J. Moazed, and D. , New Alleles of SIR2 Define Cell-Cycle-Specific Silencing Functions, Genetics, vol.173, issue.4, p.16783021, 2006.
DOI : 10.1534/genetics.106.055491

S. Harashima, A. Miller, K. Tanaka, K. Kusumoto, and K. Tanaka, Mating-type control in Saccharomyces cerevisiae: isolation and characterization of mutants defective in repression by a1-alpha 2., Molecular and Cellular Biology, vol.9, issue.10, pp.4523-4530, 1989.
DOI : 10.1128/MCB.9.10.4523

D. Sinclair and L. Guarente, Extrachromosomal rDNA Circles??? A Cause of Aging in Yeast, Cell, vol.91, issue.7, pp.1033-1042, 1997.
DOI : 10.1016/S0092-8674(00)80493-6

T. Nakagawa and L. Guarente, Sirtuins at a glance, Journal of Cell Science, vol.124, issue.6, pp.833-838, 2011.
DOI : 10.1242/jcs.081067

A. Vaquero, M. Scher, D. Lee, H. Erdjument-bromage, and P. Tempst, Human SirT1 Interacts with Histone H1 and Promotes Formation of Facultative Heterochromatin, Molecular Cell, vol.16, issue.1, pp.93-105, 2004.
DOI : 10.1016/j.molcel.2004.08.031

T. Zhang and W. Kraus, SIRT1-dependent regulation of chromatin and transcription: Linking NAD+ metabolism and signaling to the control of cellular functions, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, vol.1804, issue.8, pp.1666-1675, 2010.
DOI : 10.1016/j.bbapap.2009.10.022

S. Imai, C. Armstrong, M. Kaeberlein, and L. Guarente, Transcriptional silencing and longevity protein Sir2 is an NADdependent histone deacetylase, Nature, vol.403, 2000.

M. Gartenberg, The Sir proteins of Saccharomyces cerevisiae: mediators of transcriptional silencing and much more, Current Opinion in Microbiology, vol.3, issue.2, pp.132-13700064, 2000.
DOI : 10.1016/S1369-5274(00)00064-3

J. Lieb, X. Liu, D. Botstein, and P. Brown, Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association, Nat Genet, vol.29, pp.100-110, 2001.

J. Huang and D. Moazed, Association of the RENT complex with nontranscribed and coding regions of rDNA and a regional requirement for the replication fork block protein Fob1 in rDNA silencing, Genes & Development, vol.17, issue.17, pp.2162-2176, 2003.
DOI : 10.1101/gad.1108403

S. Kurdistani, S. Tavazoie, and M. Grunstein, Mapping Global Histone Acetylation Patterns to Gene Expression, Cell, vol.117, issue.6, pp.721-733, 2004.
DOI : 10.1016/j.cell.2004.05.023

URL : http://doi.org/10.1016/j.cell.2004.05.023

E. Cesarini, D. Alfonso, A. Camilloni, and G. , H4K16 acetylation affects recombination and ncRNA transcription at rDNA in Saccharomyces cerevisiae, Molecular Biology of the Cell, vol.23, issue.14, pp.2770-2781, 2012.
DOI : 10.1091/mbc.E12-02-0095

URL : https://hal.archives-ouvertes.fr/pasteur-00952222

P. Pasero, A. Bensimon, and E. Schwob, Single-molecule analysis reveals clustering and epigenetic regulation of replication origins at the yeast rDNA locus, Genes & Development, vol.16, issue.19, pp.2479-2484, 2002.
DOI : 10.1101/gad.232902

A. Ganley, S. Ide, K. Saka, and T. Kobayashi, The Effect of Replication Initiation on Gene Amplification in the rDNA and Its Relationship to Aging, Molecular Cell, vol.35, issue.5, pp.683-693, 2009.
DOI : 10.1016/j.molcel.2009.07.012

T. Kobayashi, T. Horiuchi, P. Tongaonkar, L. Vu, and M. Nomura, SIR2 Regulates Recombination between Different rDNA Repeats, but Not Recombination within Individual rRNA Genes in Yeast, Cell, vol.117, issue.4, pp.441-45310, 2004.
DOI : 10.1016/S0092-8674(04)00414-3

A. Straight, W. Shou, G. Dowd, C. Turck, and R. Deshaies, Net1, a Sir2-Associated Nucleolar Protein Required for rDNA Silencing and Nucleolar Integrity, Cell, vol.97, issue.2, pp.245-25610, 1999.
DOI : 10.1016/S0092-8674(00)80734-5

A. Marston, B. Lee, and A. Amon, The Cdc14 Phosphatase and the FEAR Network Control Meiotic Spindle Disassembly and Chromosome Segregation, Developmental Cell, vol.4, issue.5, pp.711-72610, 2003.
DOI : 10.1016/S1534-5807(03)00130-8

L. Verdone, G. Camilloni, D. Mauro, E. Caserta, and M. , Chromatin remodeling during Saccharomyces cerevisiae ADH2 gene activation., Molecular and Cellular Biology, vol.16, issue.5, pp.1978-1988, 1996.
DOI : 10.1128/MCB.16.5.1978

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC231185