Spatial coordination between stem cell activity and cell differentiation in the root meristem.

Abstract : A critical issue in development is the coordination of the activity of stem cell niches with differentiation of their progeny to ensure coherent organ growth. In the plant root, these processes take place at opposite ends of the meristem and must be coordinated with each other at a distance. Here, we show that in Arabidopsis, the gene SCR presides over this spatial coordination. In the organizing center of the root stem cell niche, SCR directly represses the expression of the cytokinin-response transcription factor ARR1, which promotes cell differentiation, controlling auxin production via the ASB1 gene and sustaining stem cell activity. This allows SCR to regulate, via auxin, the level of ARR1 expression in the transition zone where the stem cell progeny leaves the meristem, thus controlling the rate of differentiation. In this way, SCR simultaneously controls stem cell division and differentiation, ensuring coherent root growth.
Document type :
Journal articles
Complete list of metadatas

Cited literature [43 references]  Display  Hide  Download

https://hal-riip.archives-ouvertes.fr/pasteur-01053494
Contributor : Istituto Pasteur Fondazione Cenci Bolognetti <>
Submitted on : Thursday, July 31, 2014 - 10:57:32 AM
Last modification on : Tuesday, August 20, 2019 - 5:12:02 PM
Long-term archiving on : Tuesday, April 11, 2017 - 6:51:46 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Laila Moubayidin, Riccardo Di Mambro, Rosangela Sozzani, Elena Pacifici, Elena Salvi, et al.. Spatial coordination between stem cell activity and cell differentiation in the root meristem.. Developmental Cell, Elsevier, 2013, 26 (4), pp.405-15. ⟨10.1016/j.devcel.2013.06.025⟩. ⟨pasteur-01053494⟩

Share

Metrics

Record views

98