CX3CL1 protects neurons against excitotoxicity enhancing GLT-1 activity on astrocytes.

Abstract : In this paper we show for the first time that: i) astrocytes are required for the neuroprotective activity of CX3CL1 against excitotoxicity; ii) inhibition of the glutamate transporter 1 (GLT-1) prejudices CX3CL1-mediated neuroprotection; iii) CX3CL1 increases GLT-1 activity on astrocytes. The modulation of GLT-1 activity induced by CX3CL1 on astrocytes requires the presence and the activity of A1 adenosine receptor (A1R), being blocked by the specific antagonist DPCPX and absent in A1R(-/-) astrocytes. These data introduce the astrocytes as active players in CX3CL1-mediated signaling between microglia and neurons, identifying GLT-1 as a key mediator of the neuroprotective activity of CX3CL1.
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Submitted on : Saturday, August 2, 2014 - 12:06:26 PM
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Myriam Catalano, Clotilde Lauro, Raffaela Cipriani, Giuseppina Chece, Andrea Ponzetta, et al.. CX3CL1 protects neurons against excitotoxicity enhancing GLT-1 activity on astrocytes.. Journal of Neuroimmunology, Elsevier, 2013, 263 (1-2), pp.75-82. ⟨10.1016/j.jneuroim.2013.07.020⟩. ⟨pasteur-01053833⟩

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