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Journal articles
CX3CL1 protects neurons against excitotoxicity enhancing GLT-1 activity on astrocytes.
Abstract : In this paper we show for the first time that: i) astrocytes are required for the neuroprotective activity of CX3CL1 against excitotoxicity; ii) inhibition of the glutamate transporter 1 (GLT-1) prejudices CX3CL1-mediated neuroprotection; iii) CX3CL1 increases GLT-1 activity on astrocytes. The modulation of GLT-1 activity induced by CX3CL1 on astrocytes requires the presence and the activity of A1 adenosine receptor (A1R), being blocked by the specific antagonist DPCPX and absent in A1R(-/-) astrocytes. These data introduce the astrocytes as active players in CX3CL1-mediated signaling between microglia and neurons, identifying GLT-1 as a key mediator of the neuroprotective activity of CX3CL1.
Cited literature [49 references]
https://hal-riip.archives-ouvertes.fr/pasteur-01053833
Contributor : Istituto Pasteur Fondazione Cenci Bolognetti <>
Submitted on : Saturday, August 2, 2014 - 12:06:26 PM
Last modification on : Wednesday, October 28, 2020 - 3:20:08 PM
Contributor : Istituto Pasteur Fondazione Cenci Bolognetti <>
Submitted on : Saturday, August 2, 2014 - 12:06:26 PM
Last modification on : Wednesday, October 28, 2020 - 3:20:08 PM