E. Aronica, K. Fluiter, A. Iyer, E. Zurolo, J. Vreijling et al., Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy, European Journal of Neuroscience, vol.5, issue.Suppl. 2, pp.1100-1107, 2010.
DOI : 10.1111/j.1460-9568.2010.07122.x

E. Aronica, E. Zurolo, A. Iyer, M. De-groot, J. Anink et al., Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy, Epilepsia, vol.5, issue.Suppl. 2, pp.1645-1655, 2012.
DOI : 10.1111/j.1528-1167.2011.03115.x

C. Bertollini, D. Ragozzino, C. Gross, C. Limatola, and F. Eusebi, Fractalkine/CX3CL1 depresses central synaptic transmission in mouse hippocampal slices, Neuropharmacology, vol.51, issue.4, pp.816-821, 2006.
DOI : 10.1016/j.neuropharm.2006.05.027

I. Bl?-umcke, R. Coras, H. Miyata, and C. Ozkara, Defining Clinico-Neuropathological Subtypes of Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis, Brain Pathology, vol.495, issue.5, pp.402-411, 2012.
DOI : 10.1111/j.1750-3639.2012.00583.x

I. Bl?-umcke, E. Pauli, H. Clusmann, J. Schramm, A. Becker et al., A new clinico-pathological classification system for mesial temporal sclerosis, Acta Neuropathologica, vol.5, issue.Suppl 5, pp.235-244, 2007.
DOI : 10.1007/s00401-006-0187-0

A. Cardona, E. Pioro, M. Sasse, V. Kostenko, S. Cardona et al., Control of microglial neurotoxicity by the fractalkine receptor, Nature Neuroscience, vol.24, issue.7, pp.917-924, 2006.
DOI : 10.1038/nn1715

R. Cipriani, P. Villa, G. Chece, C. Lauro, A. Paladini et al., CX3CL1 Is Neuroprotective in Permanent Focal Cerebral Ischemia in Rodents, Journal of Neuroscience, vol.31, issue.45, pp.16327-16335, 2011.
DOI : 10.1523/JNEUROSCI.3611-11.2011

L. Conti, E. Palma, C. Roseti, C. Lauro, R. Cipriani et al., Anomalous levels of Cl??? transporters cause a decrease of GABAergic inhibition in human peritumoral epileptic cortex, Epilepsia, vol.6, issue.9, pp.1635-1644, 2011.
DOI : 10.1111/j.1528-1167.2011.03111.x

F. Eusebi, E. Palma, M. Amici, and R. Miledi, Microtransplantation of ligand-gated receptor-channels from fresh or frozen nervous tissue into Xenopus oocytes: A potent tool for expanding functional information, Progress in Neurobiology, vol.88, issue.1, pp.32-40, 2009.
DOI : 10.1016/j.pneurobio.2009.01.008

P. Fabene, P. Bramanti, and C. G. , The emerging role for chemokines in epilepsy, Journal of Neuroimmunology, vol.224, issue.1-2, pp.22-27, 2010.
DOI : 10.1016/j.jneuroim.2010.05.016

Y. Gao and R. Ji, Chemokines, neuronal???glial interactions, and central processing of neuropathic pain, Pharmacology & Therapeutics, vol.126, issue.1, pp.56-68, 2010.
DOI : 10.1016/j.pharmthera.2010.01.002

H. Grabenstatter, S. Russek, and A. Brooks-kayal, Molecular pathways controlling inhibitory receptor expression, Epilepsia, vol.91, issue.Suppl. 12, pp.71-78, 2012.
DOI : 10.1111/epi.12036

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776022

J. Harrison, Y. Jiang, S. Chen, Y. Xia, D. Maciejewski et al., Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia, Proceedings of the National Academy of Sciences, vol.95, issue.18, pp.10896-10901, 1998.
DOI : 10.1073/pnas.95.18.10896

S. Heinisch and L. Kirby, Fractalkine/CX3CL1 enhances GABA synaptic activity at serotonin neurons in the rat dorsal raphe nucleus, Neuroscience, vol.164, issue.3, pp.1210-1223, 2009.
DOI : 10.1016/j.neuroscience.2009.08.075

S. Hulshof, E. Van-haastert, H. Kuipers, P. Van-den-elsen, D. Groot et al., CR1 Expression in Human Brain Tissue: Noninflammatory Control versus Multiple Sclerosis, Journal of Neuropathology & Experimental Neurology, vol.62, issue.9, pp.899-907, 2003.
DOI : 10.1093/jnen/62.9.899

A. Iyer, E. Zurolo, W. Spliet, P. Van-rijen, J. Baayen et al., Evaluation of the innate and adaptive immunity in type I and type II focal cortical dysplasias, Epilepsia, vol.63, issue.suppl 5, pp.1763-1773, 2010.
DOI : 10.1111/j.1528-1167.2010.02547.x

D. Janigro, Inhibitory GABA Current Rundown in Epileptic Brain: Use-Dependent and Pathology-Specific Mechanisms, Epilepsy Currents, vol.6, issue.4, pp.138-139, 2006.
DOI : 10.1111/j.1535-7511.2006.00124.x

L. Jansen, L. Peugh, and J. Ojemann, GABAA receptor properties in catastrophic infantile epilepsy, Epilepsy Research, vol.81, issue.2-3, pp.188-197, 2008.
DOI : 10.1016/j.eplepsyres.2008.05.011

A. Kan, W. De-jager, M. De-wit, C. Heijnen, M. Van-zuiden et al., Protein expression profiling of inflammatory mediators in human temporal lobe epilepsy reveals co-activation of multiple chemokines and cytokines, Journal of Neuroinflammation, vol.7, issue.Suppl 3, p.207, 2012.
DOI : 10.1186/1742-2094-9-207

R. K?-ohling, A. L?-ucke, H. Straub, E. Speckmann, I. Tuxhorn et al., Spontaneous sharp waves in human neocortical slices excised from epileptic patients, Brain, vol.121, issue.6, pp.1073-1087, 1998.
DOI : 10.1093/brain/121.6.1073

S. Lee, N. Varvel, M. Konerth, G. Xu, A. Cardona et al., CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models, The American Journal of Pathology, vol.177, issue.5, pp.2549-2562, 2010.
DOI : 10.2353/ajpath.2010.100265

G. Li, K. Yang, C. Zheng, Q. Liu, Y. Chang et al., Functional rundown of gamma-aminobutyric acidA receptors in human hypothalamic hamartomas, Annals of Neurology, vol.48, issue.pt 3, pp.664-672, 2011.
DOI : 10.1002/ana.22298

C. Limatola, C. Lauro, M. Catalano, M. Ciotti, C. Bertollini et al., Chemokine CX3CL1 protects rat hippocampal neurons against glutamate-mediated excitotoxicity, Journal of Neuroimmunology, vol.166, issue.1-2, pp.19-28, 2005.
DOI : 10.1016/j.jneuroim.2005.03.023

R. Macdonald, J. Kang, and M. Gallagher, receptor subunits associated with genetic epilepsies, The Journal of Physiology, vol.28, issue.Suppl 1, pp.1861-1869, 2010.
DOI : 10.1113/jphysiol.2010.186999

L. Maggi, F. Trettel, M. Scianni, C. Bertollini, F. Eusebi et al., LTP impairment by fractalkine/CX3CL1 in mouse hippocampus is mediated through the activity of adenosine receptor type 3 (A3R), Journal of Neuroimmunology, vol.215, issue.1-2, pp.36-42, 2009.
DOI : 10.1016/j.jneuroim.2009.07.016

M. Mazzuferi, E. Palma, K. Martinello, F. Maiolino, C. Roseti et al., Enhancement of GABAA-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy, Proceedings of the National Academy of Sciences, vol.107, issue.7, pp.3180-3185, 2010.
DOI : 10.1073/pnas.0914710107

R. Miledi, F. Eusebi, M. Inez-torres, A. Palma, E. Trettel et al., Expression of functional neurotransmitter receptors in Xenopus oocytes after injection of human brain membranes, Proceedings of the National Academy of Sciences, vol.99, issue.20, pp.13238-13242, 2002.
DOI : 10.1073/pnas.192445299

R. Miledi, E. Palma, and F. Eusebi, Microtransplantation of Neurotransmitter Receptors From Cells to Xenopus Oocyte Membranes, Methods Mol Biol, vol.322, pp.347-355, 2006.
DOI : 10.1007/978-1-59745-000-3_24

M. Mortensen and T. Smart, receptors on rat hippocampal pyramidal neurons, The Journal of Physiology, vol.63, issue.3, pp.841-856, 2006.
DOI : 10.1113/jphysiol.2006.117952

E. Palma, F. Trettel, S. Fucile, M. Renzi, R. Miledi et al., Microtransplantation of membranes from cultured cells to Xenopus oocytes: A method to study neurotransmitter receptors embedded in native lipids, Proceedings of the National Academy of Sciences, vol.100, issue.5, pp.2896-2900, 2003.
DOI : 10.1073/pnas.0438006100

E. Palma, D. Ragozzino, D. Angelantonio, S. Spinelli, G. Trettel et al., Phosphatase inhibitors remove the run-down of ??-aminobutyric acid type A receptors in the human epileptic brain, Proceedings of the National Academy of Sciences, vol.101, issue.27, pp.10183-10188, 2004.
DOI : 10.1073/pnas.0403683101

E. Palma, G. Torchia, C. Limatola, F. Trettel, A. Arcella et al., BDNF modulates GABAA receptors microtransplanted from the human epileptic brain to Xenopus oocytes, Proceedings of the National Academy of Sciences, vol.102, issue.5, pp.1667-1672, 2005.
DOI : 10.1073/pnas.0409442102

E. Palma, M. Amici, F. Sobrero, G. Spinelli, D. Angelantonio et al., Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory, Proceedings of the National Academy of Sciences, vol.103, issue.22, pp.8465-8468, 2006.
DOI : 10.1073/pnas.0602979103

E. Palma, C. Roseti, F. Maiolino, S. Fucile, K. Martinello et al., GABAA-current rundown of temporal lobe epilepsy is associated with repetitive activation of GABAA "phasic" receptors, Proceedings of the National Academy of Sciences, vol.104, issue.52, pp.20944-20948, 2007.
DOI : 10.1073/pnas.0710522105

I. Pavlov, K. Kaila, D. Kullmann, and R. Miles, Cortical inhibition, pH and cell excitability in epilepsy: what are optimal targets for antiepileptic interventions?, The Journal of Physiology, vol.29, issue.Suppl 1, pp.765-774, 2013.
DOI : 10.1113/jphysiol.2012.237958

F. Pernot, C. Heinrich, L. Barbier, A. Peinnequin, P. Carpentier et al., Inflammatory changes during epileptogenesis and spontaneous seizures in a mouse model of mesiotemporal lobe epilepsy, Epilepsia, vol.7, issue.Suppl. 2, pp.2315-2325, 2011.
DOI : 10.1111/j.1528-1167.2011.03273.x

D. Ragozzino, E. Palma, D. Angelantonio, S. Amici, M. Mascia et al., Rundown of GABA type A receptors is a dysfunction associated with human drug-resistant mesial temporal lobe epilepsy, Proceedings of the National Academy of Sciences, vol.102, issue.42, pp.15219-15223, 2005.
DOI : 10.1073/pnas.0507339102

D. Ragozzino, D. Angelantonio, S. Trettel, F. Bertollini, C. et al., Chemokine Fractalkine/CX3CL1 Negatively Modulates Active Glutamatergic Synapses in Rat Hippocampal Neurons, Journal of Neuroscience, vol.26, issue.41, pp.10488-10498, 2006.
DOI : 10.1523/JNEUROSCI.3192-06.2006

R. Ransohoff, Chemokines and Chemokine Receptors: Standing at the Crossroads of Immunobiology and Neurobiology, Immunity, vol.31, issue.5, pp.711-721, 2009.
DOI : 10.1016/j.immuni.2009.09.010

T. Ravizza, F. No-e, D. Zardoni, V. Vaghi, M. Sifringer et al., Interleukin Converting Enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1?? production, Neurobiology of Disease, vol.31, issue.3, pp.327-333, 2008.
DOI : 10.1016/j.nbd.2008.05.007

C. Roseti, E. Palma, K. Martinello, S. Fucile, R. Morace et al., Blockage of A2A and A3 adenosine receptors decreases the desensitization of human GABAA receptors microtransplanted to Xenopus oocytes, Proceedings of the National Academy of Sciences, vol.106, issue.37, pp.15927-15931, 2009.
DOI : 10.1073/pnas.0907324106

R. Saliba, K. Kretschmannova, and S. Moss, receptors regulates receptor insertion and tonic current, The EMBO Journal, vol.127, issue.13, pp.2937-2951, 2012.
DOI : 10.1038/emboj.2012.109

A. Sosunov, X. Wu, R. Mcgovern, D. Coughlin, C. Mikell et al., The mTOR pathway is activated in glial cells in mesial temporal sclerosis, Epilepsia, vol.28, issue.Suppl. 2, pp.78-86, 2012.
DOI : 10.1111/j.1528-1167.2012.03478.x

B. Stell, S. Brickley, C. Tang, M. Farrant, and I. Mody, Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by ?? subunit-containing GABAA receptors, Proceedings of the National Academy of Sciences, vol.100, issue.24, pp.14439-14444, 2003.
DOI : 10.1073/pnas.2435457100

A. Vezzani, Before Epilepsy Unfolds: Finding the epileptogenesis switch, Nature Medicine, vol.18, issue.11, pp.1626-1627, 2012.
DOI : 10.4161/cc.9.12.11866

A. Vezzani, S. Balosso, E. Aronica, and T. Ravizza, Basic mechanisms of status epilepticus due to infection and inflammation, Epilepsia, vol.7, issue.suppl 5, pp.56-57, 2009.
DOI : 10.1111/j.1528-1167.2009.02370.x

A. Vezzani, J. French, T. Bartfai, and T. Baram, The role of inflammation in epilepsy, Nature Reviews Neurology, vol.36, issue.1, pp.31-40, 2011.
DOI : 10.1038/nrneurol.2010.178

A. Vezzani, E. Aronica, A. Mazarati, and Q. Pittman, Epilepsy and brain inflammation, Experimental Neurology, vol.244, pp.11-21, 2013.
DOI : 10.1016/j.expneurol.2011.09.033

A. Vezzani, S. Balosso, and T. Ravizza, Inflammation and epilepsy, Handb Clin Neurol, vol.107, pp.163-175, 2012.
DOI : 10.1016/B978-0-444-52898-8.00010-0

URL : https://hal.archives-ouvertes.fr/hal-01262896

Y. Wu, X. Wang, X. Mo, Z. Xi, F. Xiao et al., Expression of monocyte chemoattractant protein-1 in brain tissue of patients with intractable epilepsy, Clinical Neuropathology, vol.27, issue.03, pp.55-63, 2008.
DOI : 10.5414/NPP27055

Y. Xu, K. Zeng, Y. Han, L. Wang, D. Chen et al., Altered Expression of CX3CL1 in Patients with Epilepsy and in a Rat Model, The American Journal of Pathology, vol.180, issue.5, pp.1950-1962, 2012.
DOI : 10.1016/j.ajpath.2012.01.024

T. Yang, D. Zhou, and S. H. , Why mesial temporal lobe epilepsy with hippocampal sclerosis is progressive: Uncontrolled inflammation drives disease progression?, Journal of the Neurological Sciences, vol.296, issue.1-2, pp.1-6, 2010.
DOI : 10.1016/j.jns.2010.06.002

S. Yeo, J. Kim, H. Ryu, C. Seo, B. Lee et al., The roles of fractalkine/CX3CR1 system in neuronal death following pilocarpine-induced status epilepticus, Journal of Neuroimmunology, vol.234, issue.1-2, pp.93-102, 2011.
DOI : 10.1016/j.jneuroim.2011.03.005