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Journal articles
Functional cross talk between CXCR4 and PDGFR on glioblastoma cells is essential for migration.
Miriam Sciaccaluga
1
Giuseppina d'Alessandro
2
Francesca Pagani
3
Giuseppina Ferrara
4
Nadia Lopez
4
Tracy Warr
4
Paolo Gorello
5
Alessandra Porzia
6
Fabrizio Mainiero
7
Antonio Santoro
8
Vincenzo Esposito
1
Giampaolo Cantore
1
Emilia Castigli
4
Cristina Limatola
1, 2, *
*
Corresponding author
Miriam Sciaccaluga 1
Author
Giuseppina d'Alessandro 2
Author
Francesca Pagani 3
Author
Giuseppina Ferrara 4
Author
Fabrizio Mainiero 7
Author
Antonio Santoro 8
Author
Vincenzo Esposito 1
Author
Giampaolo Cantore 1
Author
Emilia Castigli 4
Author
Cristina Limatola 1, 2
Correspondent author
1
NEUROMED I.R.C.C.S. - Istituto Neurologico Mediterraneo (Via Atinense, 18, 86077 Pozzilli, IS - Italy)
- Università degli Studi di Roma "La Sapienza" [Rome] (Piazzale Aldo Moro 5, 00185 Roma - Italy)
- Università degli studi di Napoli Federico II (Corso Umberto I 40 - 80138 Napoli - Italy)
2
Department of Physiology and Pharmacology (Italy)
- Università degli Studi di Roma "La Sapienza" [Rome] (Piazzale Aldo Moro 5, 00185 Roma - Italy)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
- Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti (Université de Rome La Sapienza 5 Place Aldo Moro 00185 Rome - Italy)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
3
Centre for Life Nano Science at Sapienza (Italy)
- IIT - Istituto Italiano di Tecnologia (Via Morego, 30 16163 Genova - Italy)
4
Department of Cellular and Environmental Biology (Italy)
- UNIPG - Università degli Studi di Perugia (piazza Università, 1, 06123 Perugia - Italy)
5
Department of Hematology (Italy)
- UNIPG - Università degli Studi di Perugia (piazza Università, 1, 06123 Perugia - Italy)
6
Department of Molecular Medicine (Italy)
- Università degli Studi di Roma "La Sapienza" [Rome] (Piazzale Aldo Moro 5, 00185 Roma - Italy)
7
Department of Experimental Medicine (Rome - Italy)
- Università degli Studi di Roma "La Sapienza" [Rome] (Piazzale Aldo Moro 5, 00185 Roma - Italy)
8
Department of Neurology and Psychiatry (Italy)
- Università degli Studi di Roma "La Sapienza" [Rome] (Piazzale Aldo Moro 5, 00185 Roma - Italy)
Abstract : Glioblastoma (GBM) is the most common and aggressive form of brain tumor, characterized by high migratory behavior and infiltration in brain parenchyma which render classic therapeutic approach ineffective. The migratory behaviour of GBM cells could be conditioned by a number of tissue- and glioma-derived cytokines and growth factors. Although the pro-migratory action of CXCL12 on GBM cells in vitro and in vivo is recognized, the molecular mechanisms involved are not clearly identified. In fact the signaling pathways involved in the pro-migratory action of CXCL12 may differ in individual glioblastoma and integrate with those resulting from abnormal expression and activation of growth factor receptors. In this study we investigated whether some of the receptor tyrosine kinases commonly expressed in GBM cells could cooperate with CXCL12/CXCR4 in their migratory behavior. Our results show a functional cross-talk between CXCR4 and PDGFR which appears to be essential for GBM chemotaxis.
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Journal articles
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https://hal-riip.archives-ouvertes.fr/pasteur-01053840
Contributor : Istituto Pasteur Fondazione Cenci Bolognetti <>
Submitted on : Saturday, August 2, 2014 - 12:46:02 PM
Last modification on : Thursday, July 11, 2019 - 2:10:07 PM
Long-term archiving on: : Tuesday, April 11, 2017 - 6:44:28 PM
Contributor : Istituto Pasteur Fondazione Cenci Bolognetti <>
Submitted on : Saturday, August 2, 2014 - 12:46:02 PM
Last modification on : Thursday, July 11, 2019 - 2:10:07 PM
Long-term archiving on: : Tuesday, April 11, 2017 - 6:44:28 PM
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Identifiers
- HAL Id : pasteur-01053840, version 1
- DOI : 10.1371/journal.pone.0073426
- PUBMED : 24023874
Citation
Miriam Sciaccaluga, Giuseppina d'Alessandro, Francesca Pagani, Giuseppina Ferrara, Nadia Lopez, et al.. Functional cross talk between CXCR4 and PDGFR on glioblastoma cells is essential for migration.. PLoS ONE, Public Library of Science, 2013, 8 (9), pp.e73426. ⟨10.1371/journal.pone.0073426⟩. ⟨pasteur-01053840⟩
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