J. Menendez and R. Lupu, Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis, Nature Reviews Cancer, vol.280, issue.10, pp.763-777, 2007.
DOI : 10.1038/nrc2222

R. Igal, Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer, Carcinogenesis, vol.31, issue.9, pp.1509-1515, 2010.
DOI : 10.1093/carcin/bgq131

J. Ntambi, Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol, J Lipid Res, vol.40, pp.1549-1558, 1999.

L. Riboni, R. Ghidoni, S. Sonnino, F. Omodeo-salè, S. Gaini et al., Phospholipid content and composition of human meningiomas, Neurochemical Pathology, vol.49, issue.3, pp.171-188, 1984.
DOI : 10.1007/BF02834351

L. Zhang, L. Ge, S. Parimoo, K. Stenn, and S. Prouty, Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites, Biochemical Journal, vol.340, issue.1, pp.255-264, 1999.
DOI : 10.1042/bj3400255

S. Beiraghi, M. Zhou, C. Talmadge, N. Went-sumegi, J. Davis et al., Identification and characterization of a novel gene disrupted by a pericentric inversion inv(4)(p13.1q21.1) in a family with cleft lip, Gene, vol.309, issue.1, pp.11-21, 2003.
DOI : 10.1016/S0378-1119(03)00461-X

J. Robert, D. Montaudon, and P. Hugues, Incorporation and metabolism of exogenous fatty acids by cultured normal and tumoral glial cells, Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol.752, issue.3, pp.383-395, 1983.
DOI : 10.1016/0005-2760(83)90268-0

N. Scaglia, J. Chisholm, and R. Igal, Inhibition of StearoylCoA Desaturase-1 Inactivates Acetyl-CoA Carboxylase and Impairs Proliferation in Cancer Cells: Role of AMPK, PLoS ONE, vol.88, issue.8, p.6812, 2009.
DOI : 10.1371/journal.pone.0006812.g009

P. Mason, B. Liang, L. Li, T. Fremgen, E. Murphy et al., SCD1 Inhibition Causes Cancer Cell Death by Depleting Mono-Unsaturated Fatty Acids, PLoS ONE, vol.45, issue.6, p.33823, 2012.
DOI : 10.1371/journal.pone.0033823.g004

U. Roongta, J. Pabalan, X. Wang, R. Ryseck, J. Fargnoli et al., Cancer Cell Dependence on Unsaturated Fatty Acids Implicates Stearoyl-CoA Desaturase as a Target for Cancer Therapy, Molecular Cancer Research, vol.9, issue.11, pp.1551-1561, 2011.
DOI : 10.1158/1541-7786.MCR-11-0126

D. Hess and R. Igal, lipid synthesis and impairs cell proliferation in human lung cancer cells, Experimental Biology and Medicine, vol.271, issue.6, pp.707-713, 2011.
DOI : 10.1152/ajpendo.00644.2005

X. Du, Q. Wang, E. Chan, M. Merchant, J. Liu et al., FGFR3 Stimulates Stearoyl CoA Desaturase 1 Activity to Promote Bladder Tumor Growth, Cancer Research, vol.72, issue.22, pp.5843-5855, 2012.
DOI : 10.1158/0008-5472.CAN-12-1329

V. Fritz, Z. Benfodda, G. Rodier, C. Henriquet, F. Iborra et al., Abrogation of De novo Lipogenesis by Stearoyl-CoA Desaturase 1 Inhibition Interferes with Oncogenic Signaling and Blocks Prostate Cancer Progression in Mice, Molecular Cancer Therapeutics, vol.9, issue.6, pp.1740-1754, 2010.
DOI : 10.1158/1535-7163.MCT-09-1064
URL : https://hal.archives-ouvertes.fr/inserm-00544679

D. Luyimbazi, A. Akcakanat, P. Mcauliffe, L. Zhang, G. Singh et al., Rapamycin Regulates Stearoyl CoA Desaturase 1 Expression in Breast Cancer, Molecular Cancer Therapeutics, vol.9, issue.10, pp.2770-2784, 2010.
DOI : 10.1158/1535-7163.MCT-09-0980

N. Scaglia and R. Igal, Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis, Int J Oncol, vol.33, pp.839-850, 2008.

C. Von-roemeling, L. Marlow, J. Wei, S. Cooper, T. Caulfield et al., Stearoyl-CoA Desaturase 1 Is a Novel Molecular Therapeutic Target for Clear Cell Renal Cell Carcinoma, Clinical Cancer Research, vol.19, issue.9, pp.2368-2380, 2013.
DOI : 10.1158/1078-0432.CCR-12-3249

E. Isabel, D. Powell, W. Black, C. Chan, S. Crane et al., Biological activity and preclinical efficacy of azetidinyl pyridazines as potent systemically-distributed stearoyl-CoA desaturase inhibitors, Bioorganic & Medicinal Chemistry Letters, vol.21, issue.1, pp.479-483, 2011.
DOI : 10.1016/j.bmcl.2010.10.107

S. Léger, W. Black, D. Deschenes, S. Dolman, J. Falgueyret et al., Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438), Bioorganic & Medicinal Chemistry Letters, vol.20, issue.2, pp.499-502, 2010.
DOI : 10.1016/j.bmcl.2009.11.111

L. Nguyen, R. Vanner, P. Dirks, and C. Eaves, Cancer stem cells: an evolving concept, Nature Reviews Cancer, vol.11, pp.133-143, 2012.
DOI : 10.1038/nrc3184

A. Conway, A. Lindgren, Z. Galic, A. Pyle, H. Wu et al., A Self-Renewal Program Controls the Expansion of Genetically Unstable Cancer Stem Cells in Pluripotent Stem Cell-Derived Tumors, Stem Cells, vol.131, issue.132, pp.18-28, 2009.
DOI : 10.1634/stemcells.2008-0529

A. Eramo, F. Lotti, G. Sette, E. Pilozzi, M. Biffoni et al., Identification and expansion of the tumorigenic lung cancer stem cell population, Cell Death and Differentiation, vol.161, issue.3, pp.504-514, 2008.
DOI : 10.1126/science.273.5272.242

G. Dontu and M. Wicha, Survival of Mammary Stem Cells in Suspension Culture: Implications for Stem Cell Biology and Neoplasia, Journal of Mammary Gland Biology and Neoplasia, vol.101, issue.10, pp.75-86, 2005.
DOI : 10.1007/s10911-005-2542-5

S. Akunuru, J. Zhai, Q. Zheng, and Y. , Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity, Cell Death and Disease, vol.278, issue.7, p.352, 2012.
DOI : 10.1038/cddis.2012.93

M. Bartucci, S. Svensson, P. Romania, R. Dattilo, M. Patrizii et al., Therapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy, Cell Death and Differentiation, vol.3, issue.5, pp.768-778, 2012.
DOI : 10.1002/cncr.24060

L. Abdullah and E. Chow, Mechanisms of chemoresistance in cancer stem cells, Clinical and Translational Medicine, vol.2, issue.1, pp.1326-1328, 2013.
DOI : 10.1002/stem.595

S. Deng, X. Yang, H. Lassus, S. Liang, S. Kaur et al., Distinct Expression Levels and Patterns of Stem Cell Marker, Aldehyde Dehydrogenase Isoform 1 (ALDH1), in Human Epithelial Cancers, PLoS ONE, vol.5, issue.4, p.10277, 2010.
DOI : 10.1371/journal.pone.0010277.s004

J. Sullivan, M. Spinola, M. Dodge, M. Raso, C. Behrens et al., Aldehyde Dehydrogenase Activity Selects for Lung Adenocarcinoma Stem Cells Dependent on Notch Signaling, Cancer Research, vol.70, issue.23, pp.9937-9948, 2010.
DOI : 10.1158/0008-5472.CAN-10-0881

D. Ucar, C. Cogle, J. Zucali, B. Ostmark, E. Scott et al., Aldehyde dehydrogenase activity as a functional marker for lung cancer, Chemico-Biological Interactions, vol.178, issue.1-3, pp.48-55, 2009.
DOI : 10.1016/j.cbi.2008.09.029

J. Moreb, Aldehyde Dehydrogenase as a Marker for Stem Cells, Current Stem Cell Research & Therapy, vol.3, issue.4, pp.237-246, 2008.
DOI : 10.2174/157488808786734006

R. Mancini, E. Giarnieri, D. Vitis, C. Malanga, D. Roscilli et al., Spheres Derived from Lung Adenocarcinoma Pleural Effusions: Molecular Characterization and Tumor Engraftment, PLoS ONE, vol.20, issue.14, p.21320, 2011.
DOI : 10.1371/journal.pone.0021320.s007

A. Ricci, D. Vitis, C. Noto, A. Fattore, L. Mariotta et al., TrkB is responsible for EMT transition in malignant pleural effusions derived cultures from adenocarcinoma of the lung, Cell Cycle, vol.22, issue.11, pp.1696-1703, 2013.
DOI : 10.4161/cc.24759

R. Herbst, J. Heymach, and S. Lippman, Lung Cancer, New England Journal of Medicine, vol.359, issue.13, pp.1367-1380, 2008.
DOI : 10.1056/NEJMra0802714

S. Mani, W. Guo, M. Liao, E. Eaton, A. Ayyanan et al., The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells, Cell, vol.133, issue.4, pp.704-715, 2008.
DOI : 10.1016/j.cell.2008.03.027

F. Garcia-gonzalo, I. Belmonte, and J. , Albumin-Associated Lipids Regulate Human Embryonic Stem Cell Self-Renewal, PLoS ONE, vol.447, issue.1, p.1384, 2008.
DOI : 10.1371/journal.pone.0001384.t002
URL : http://doi.org/10.1371/journal.pone.0001384

U. Ben-david, Q. Gan, T. Golan-lev, P. Arora, O. Yanuka et al., Selective Elimination of Human Pluripotent Stem Cells by an Oleate Synthesis Inhibitor Discovered in a High-Throughput Screen, Cell Stem Cell, vol.12, issue.2, pp.167-167, 2013.
DOI : 10.1016/j.stem.2012.11.015

D. Mauvoisin, C. Charfi, A. Lounis, E. Rassart, and C. Mounier, Decreasing stearoyl-CoA desaturase-1 expression inhibits ??-catenin signaling in breast cancer cells, Cancer Science, vol.7, issue.1, pp.36-42, 2013.
DOI : 10.1111/cas.12032

E. Giarnieri, D. Vitis, C. Noto, A. Roscilli, G. Salerno et al., EMT markers in lung adenocarcinoma pleural effusion spheroid cells, Journal of Cellular Physiology, vol.699, issue.8, p.8, 2013.
DOI : 10.1002/jcp.24300

T. Li, Y. Su, Y. Mei, Q. Leng, B. Leng et al., ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients??? outcome, Laboratory Investigation, vol.414, issue.2, pp.234-244, 2010.
DOI : 10.1002/ijc.21749

J. Kelm, N. Timmins, C. Brown, M. Fussenegger, and L. Nielsen, Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types, Biotechnology and Bioengineering, vol.123, issue.2, pp.173-180, 2003.
DOI : 10.1002/bit.10655

M. Vinci, S. Gowan, F. Boxall, L. Patterson, M. Zimmermann et al., Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation, BMC Biology, vol.10, issue.1, pp.10-29, 2012.
DOI : 10.1038/bjc.1981.115