D. Selkoe, Alzheimer's Disease, Cold Spring Harbor Perspectives in Biology, vol.3, issue.7, pp.741-766, 2001.
DOI : 10.1101/cshperspect.a004457

E. Marcello, R. Epis, C. Saraceno, D. Luca, and M. , Synaptic Dysfunction in Alzheimer???s Disease, Adv Exp Med Biol, vol.970, pp.573-601, 2012.
DOI : 10.1007/978-3-7091-0932-8_25

P. Penzes, M. Cahill, K. Jones, J. Vanleeuwen, and K. Woolfrey, Dendritic spine pathology in neuropsychiatric disorders, Nature Neuroscience, vol.11, issue.3, pp.285-293, 2011.
DOI : 10.1038/nn.2583

J. Hardy and D. Selkoe, The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics, Science, vol.297, issue.5580, pp.353-356, 2002.
DOI : 10.1126/science.1072994

J. Hardy and G. Higgins, Alzheimer's disease: the amyloid cascade hypothesis, Science, vol.256, issue.5054, pp.184-185, 1992.
DOI : 10.1126/science.1566067

R. Vassar, Beta-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE, Science, vol.286, issue.5440, pp.735-741, 1999.
DOI : 10.1126/science.286.5440.735

C. Haass, Take five???BACE and the ??-secretase quartet conduct Alzheimer's amyloid ??-peptide generation, The EMBO Journal, vol.23, issue.3, pp.483-488, 2004.
DOI : 10.1038/sj.emboj.7600061

P. Kuhn, ADAM10 is the physiologically relevant, constitutive ??-secretase of the amyloid precursor protein in primary neurons, The EMBO Journal, vol.16, issue.17, pp.3020-3032, 2010.
DOI : 10.1126/science.1132341

S. Lammich, Constitutive and regulated ??-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease, Proceedings of the National Academy of Sciences, vol.96, issue.7, pp.3922-3927, 1999.
DOI : 10.1073/pnas.96.7.3922

P. Gutwein, ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles, The FASEB Journal, vol.17, issue.2, pp.292-294, 2003.
DOI : 10.1096/fj.02-0430fje

A. Kinoshita, H. Fukumoto, T. Shah, C. Whelan, M. Irizarry et al., Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes, Journal of Cell Science, vol.116, issue.16, pp.3339-3346, 2003.
DOI : 10.1242/jcs.00643

E. Marcello, Synapse-Associated Protein-97 Mediates ??-Secretase ADAM10 Trafficking and Promotes Its Activity, Journal of Neuroscience, vol.27, issue.7, pp.1682-1691, 2007.
DOI : 10.1523/JNEUROSCI.3439-06.2007

M. Malinverno, Synaptic Localization and Activity of ADAM10 Regulate Excitatory Synapses through N-Cadherin Cleavage, Journal of Neuroscience, vol.30, issue.48, pp.16343-16355, 2010.
DOI : 10.1523/JNEUROSCI.1984-10.2010

F. Gardoni, The neuropeptide PACAP38 induces dendritic spine remodeling through ADAM10-N-cadherin signaling pathway, Journal of Cell Science, vol.125, issue.6, pp.1401-1406, 2012.
DOI : 10.1242/jcs.097576

E. Marcello, SAP97-mediated local trafficking is altered in Alzheimer disease patients' hippocampus, Neurobiology of Aging, vol.33, issue.2, pp.422-423, 2012.
DOI : 10.1016/j.neurobiolaging.2010.09.015

R. Epis, Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease, Brain, vol.133, issue.11, pp.3323-3335, 2010.
DOI : 10.1093/brain/awq217

M. Ehlers, Reinsertion or Degradation of AMPA Receptors Determined by Activity-Dependent Endocytic Sorting, Neuron, vol.28, issue.2, pp.511-525, 2000.
DOI : 10.1016/S0896-6273(00)00129-X

H. Mcmahon and E. Boucrot, Molecular mechanism and physiological functions of clathrin-mediated endocytosis, Nature Reviews Molecular Cell Biology, vol.84, issue.8, pp.517-533, 2011.
DOI : 10.1038/nrm3151

T. Blanpied, D. Scott, and M. Ehlers, Dynamics and Regulation of Clathrin Coats at Specialized Endocytic Zones of Dendrites and Spines, Neuron, vol.36, issue.3, pp.435-449, 2002.
DOI : 10.1016/S0896-6273(02)00979-0

B. Racz, T. Blanpied, M. Ehlers, and R. Weinberg, Lateral organization of endocytic machinery in dendritic spines, Nature Neuroscience, vol.21, issue.9, pp.917-918, 2004.
DOI : 10.1038/10172

R. Carroll, D. Lissin, M. Von-zastrow, R. Nicoll, and R. Malenka, Rapid redistribution of glutamate receptors contributes to long-term depression in hippocampal cultures, Nat Neurosci, vol.2, issue.5, pp.454-460, 1999.

E. Beattie, Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD, Nat Neurosci, vol.3, issue.12, pp.1291-1300, 2000.

D. Harold, Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease, Nature Genetics, vol.34, issue.10, pp.1088-1093, 2009.
DOI : 10.1038/ng.440

J. Lambert, Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease, Nature Genetics, vol.12, issue.10, pp.1094-1099, 2009.
DOI : 10.1038/ng.439

S. Seshadri, Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease, JAMA, vol.303, issue.18, pp.1832-1840, 2010.
DOI : 10.1001/jama.2010.574

S. Treusch, Functional Links Between A?? Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast, Science, vol.334, issue.6060, pp.1241-1245, 2011.
DOI : 10.1126/science.1213210

R. Thomas, M. Lelos, M. Good, and E. Kidd, Clathrin-mediated endocytic proteins are upregulated in the cortex of the Tg2576 mouse model of Alzheimer???s disease-like amyloid pathology, Biochemical and Biophysical Research Communications, vol.415, issue.4, pp.656-661, 2011.
DOI : 10.1016/j.bbrc.2011.10.131

J. Bonifacino and L. Traub, Signals for Sorting of Transmembrane Proteins to Endosomes and Lysosomes, Annual Review of Biochemistry, vol.72, issue.1, pp.395-447, 2003.
DOI : 10.1146/annurev.biochem.72.121801.161800

H. Braak and E. Braak, Neuropathological stageing of Alzheimer-related changes, Acta Neuropathologica, vol.80, issue.4, pp.239-259, 1991.
DOI : 10.1007/BF00308809

D. Owen and P. Evans, A Structural Explanation for the Recognition of Tyrosine-Based Endocytotic Signals, Science, vol.282, issue.5392, pp.1327-1332, 1998.
DOI : 10.1126/science.282.5392.1327

I. Rapoport, Y. Chen, P. Cupers, S. Shoelson, and T. Kirchhausen, Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site, The EMBO Journal, vol.17, issue.8, pp.2148-2155, 1998.
DOI : 10.1093/emboj/17.8.2148

V. Haucke, M. Wenk, E. Chapman, K. Farsad, D. Camilli et al., Dual interaction of synaptotagmin with micro2- and alpha-adaptin facilitates clathrin-coated pit nucleation, The EMBO Journal, vol.19, issue.22, pp.6011-6019, 2000.
DOI : 10.1093/emboj/19.22.6011

D. Diviani, A. Lattion, L. Abuin, O. Staub, and S. Cotecchia, The Adaptor Complex 2 Directly Interacts with the ??1b-Adrenergic Receptor and Plays a Role in Receptor Endocytosis, Journal of Biological Chemistry, vol.278, issue.21, pp.19331-19340, 2003.
DOI : 10.1074/jbc.M302110200

K. Kastning, Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2, Proceedings of the National Academy of Sciences, vol.104, issue.8, pp.2991-2996, 2007.
DOI : 10.1073/pnas.0611170104

J. Bonifacino, P. Cosson, and R. Klausner, Colocalized transmembrane determinants for ER degradation and subunit assembly explain the intracellular fate of TCR chains, Cell, vol.63, issue.3, pp.503-513, 1990.
DOI : 10.1016/0092-8674(90)90447-M

E. Marcello, F. Gardoni, D. Luca, M. Perez-otano, and I. , An Arginine Stretch Limits ADAM10 Exit from the Endoplasmic Reticulum, Journal of Biological Chemistry, vol.285, issue.14, pp.10376-10384, 2010.
DOI : 10.1074/jbc.M109.055947

R. Carey, J. Blusztajn, and B. Slack, Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin, BMC Cell Biology, vol.12, issue.1, p.20, 2011.
DOI : 10.1073/pnas.95.13.7281

T. Tousseyn, ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase

E. Parkin and B. Harris, A disintegrin and metalloproteinase (ADAM)-mediated ectodomain shedding of ADAM10, Journal of Neurochemistry, vol.158, issue.6, pp.1464-1479, 2009.
DOI : 10.1111/j.1471-4159.2009.05907.x

H. Berman, The Protein Data Bank, Nucleic Acids Research, vol.28, issue.1, pp.235-242, 2000.
DOI : 10.1093/nar/28.1.235

S. Feng, C. Kasahara, R. Rickles, and S. Schreiber, Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands., Proceedings of the National Academy of Sciences, vol.92, issue.26, pp.12408-12415, 1995.
DOI : 10.1073/pnas.92.26.12408

P. Gherardini, G. Ausiello, and M. Helmer-citterich, Superpose3D: A Local Structural Comparison Program That Allows for User-Defined Structure Representations, PLoS ONE, vol.19, issue.8, p.11988, 2010.
DOI : 10.1371/journal.pone.0011988.g008

T. Newpher and M. Ehlers, Glutamate Receptor Dynamics in Dendritic Microdomains, Neuron, vol.58, issue.4, pp.472-497, 2008.
DOI : 10.1016/j.neuron.2008.04.030

F. Gardoni, M. E. , D. Luca, and M. , Postsynaptic density???membrane associated guanylate kinase proteins (PSD???MAGUKs) and their role in CNS disorders, Neuroscience, vol.158, issue.1, pp.324-333, 2009.
DOI : 10.1016/j.neuroscience.2008.07.068

M. Howard, G. Elias, L. Elias, W. Swat, and R. Nicoll, The role of SAP97 in synaptic glutamate receptor dynamics, Proceedings of the National Academy of Sciences, vol.107, issue.8, pp.3805-3810, 2010.
DOI : 10.1073/pnas.0914422107

G. Collingridge, J. Isaac, and Y. Wang, Receptor trafficking and synaptic plasticity, Nature Reviews Neuroscience, vol.22, issue.12, pp.952-962, 2004.
DOI : 10.1523/JNEUROSCI.0364-04.2004

D. Walsh and D. Selkoe, Deciphering the Molecular Basis of Memory Failure in Alzheimer's Disease, Neuron, vol.44, issue.1, pp.181-193, 2004.
DOI : 10.1016/j.neuron.2004.09.010

M. Oh, V. Derkach, E. Guire, and T. Soderling, Extrasynaptic Membrane Trafficking Regulated by GluR1 Serine 845 Phosphorylation Primes AMPA Receptors for Long-term Potentiation, Journal of Biological Chemistry, vol.281, issue.2, pp.752-758, 2006.
DOI : 10.1074/jbc.M509677200

N. Otmakhov, Forskolin-Induced LTP in the CA1 Hippocampal Region Is NMDA Receptor Dependent, Journal of Neurophysiology, vol.91, issue.5, pp.1955-1962, 2004.
DOI : 10.1152/jn.00941.2003

J. Lin, Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization, Nature Neuroscience, vol.3, issue.12, pp.1282-1290, 2000.
DOI : 10.1038/81814

I. Perez-otano, Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1, Nature Neuroscience, vol.285, issue.5, pp.611-621, 2006.
DOI : 10.1038/nn1680

R. Hall and T. Soderling, Quantitation of AMPA receptor surface expression in cultured hippocampal neurons, Neuroscience, vol.78, issue.2, pp.361-371, 1997.
DOI : 10.1016/S0306-4522(96)00525-8

K. Roche, O. Brien, R. Mammen, A. Bernhardt, J. Huganir et al., Characterization of Multiple Phosphorylation Sites on the AMPA Receptor GluR1 Subunit, Neuron, vol.16, issue.6, pp.1179-1188, 1996.
DOI : 10.1016/S0896-6273(00)80144-0

F. Gardoni, C. Bellone, F. Cattabeni, D. Luca, and M. , Protein Kinase C Activation Modulates ??-Calmodulin Kinase II Binding to NR2A Subunit of N-Methyl-D-Aspartate Receptor Complex, Journal of Biological Chemistry, vol.276, issue.10, pp.7609-7613, 2001.
DOI : 10.1074/jbc.M009922200

Y. Fukata, H. Adesnik, T. Iwanaga, D. Bredt, R. Nicoll et al., Epilepsy-Related Ligand/Receptor Complex LGI1 and ADAM22 Regulate Synaptic Transmission, Science, vol.313, issue.5794, pp.1792-1795, 2006.
DOI : 10.1126/science.1129947

H. Kasai, M. Fukuda, S. Watanabe, A. Hayashi-takagi, and J. Noguchi, Structural dynamics of dendritic spines in memory and cognition, Trends in Neurosciences, vol.33, issue.3, pp.121-129, 2010.
DOI : 10.1016/j.tins.2010.01.001

Q. Zhou, K. Homma, and M. Poo, Shrinkage of Dendritic Spines Associated with Long-Term Depression of Hippocampal Synapses, Neuron, vol.44, issue.5, pp.749-757, 2004.
DOI : 10.1016/j.neuron.2004.11.011

F. Kamenetz, APP Processing and Synaptic Function, Neuron, vol.37, issue.6, pp.925-937, 2003.
DOI : 10.1016/S0896-6273(03)00124-7

URL : http://doi.org/10.1016/s0896-6273(03)00124-7

D. Tampellini, Synaptic Activity Reduces Intraneuronal A??, Promotes APP Transport to Synapses, and Protects against A??-Related Synaptic Alterations, Journal of Neuroscience, vol.29, issue.31, pp.9704-9713, 2009.
DOI : 10.1523/JNEUROSCI.2292-09.2009

J. Pruessmeyer and A. Ludwig, The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer, Seminars in Cell & Developmental Biology, vol.20, issue.2, pp.164-174, 2009.
DOI : 10.1016/j.semcdb.2008.09.005

C. Blobel, ADAMs: key components in EGFR signalling and development, Nature Reviews Molecular Cell Biology, vol.70, issue.1, pp.32-43, 2005.
DOI : 10.1016/S0092-8674(00)80519-X

D. Seals and S. Courtneidge, The ADAMs family of metalloproteases: multidomain proteins with multiple functions, Genes & Development, vol.17, issue.1, pp.7-30, 2003.
DOI : 10.1101/gad.1039703

S. Lichtenthaler, Alpha-Secretase Cleavage of the Amyloid Precursor Protein: Proteolysis Regulated by Signaling Pathways and Protein Trafficking, Current Alzheimer Research, vol.9, issue.2, pp.165-177, 2011.
DOI : 10.2174/156720512799361655

J. Prox, Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10, Cellular and Molecular Life Sciences, vol.40, issue.5, pp.2919-2932, 2012.
DOI : 10.1007/s00018-012-0960-2

M. Israel, Probing sporadic and familial Alzheimer???s disease using induced pluripotent stem cells, Nature, vol.28, issue.7384, pp.216-220, 2012.
DOI : 10.1038/nature10821

J. Cirrito, Synaptic Activity Regulates Interstitial Fluid Amyloid-?? Levels In Vivo, Neuron, vol.48, issue.6, pp.913-922, 2005.
DOI : 10.1016/j.neuron.2005.10.028

D. Mauceri, F. Cattabeni, D. Luca, M. Gardoni, and F. , Calcium/Calmodulin-dependent Protein Kinase II Phosphorylation Drives Synapse-associated Protein 97 into Spines, Journal of Biological Chemistry, vol.279, issue.22, pp.23813-23821, 2004.
DOI : 10.1074/jbc.M402796200

A. Mammen, R. Huganir, O. Brien, and R. , Redistribution and stabilization of cell surface glutamate receptors during synapse formation, J Neurosci, vol.17, pp.7351-7358, 1997.