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Chemotherapy-elicited upregulation of NKG2D and DNAM-1 ligands as a therapeutic target in multiple myeloma.

Abstract : Malignant cells constitutively express Natural killer group 2, member D (NKG2D) or DNAX Accessory Molecule-1 (DNAM-1) ligands, yet they are often unable to trigger a robust cytotoxic cell response. It may be therapeutically useful to implement strategies aimed at increasing the density of NKG2D and DNAM-1 ligands on the surface of cancer cells, endowing them with the capacity to activate potent antitumor natural killer-cell responses.
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https://hal-riip.archives-ouvertes.fr/pasteur-01054170
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Submitted on : Tuesday, August 5, 2014 - 11:55:18 AM
Last modification on : Wednesday, October 10, 2018 - 3:26:01 PM
Long-term archiving on: : Tuesday, April 11, 2017 - 6:57:09 PM

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Alessandra Soriani, Cinzia Fionda, Biancamaria Ricci, Maria Luisa Iannitto, Marco Cippitelli, et al.. Chemotherapy-elicited upregulation of NKG2D and DNAM-1 ligands as a therapeutic target in multiple myeloma.. OncoImmunology, Taylor & Francis, 2013, 2 (12), pp.e26663. ⟨10.4161/onci.26663⟩. ⟨pasteur-01054170⟩

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