R. L. Allen, C. A. O-'callaghan, A. J. Mcmichael, and P. Bowness, Cutting edge: HLA-B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structure, Journal of Immunology, vol.162, pp.5045-5048, 1999.

J. R. Almeida, D. A. Price, L. Papagno, Z. A. Arkoub, D. Sauce et al., T cells is reflected by their avidity, polyfunctionality, and clonal turnover, The Journal of Experimental Medicine, vol.93, issue.10, pp.2473-2485, 2007.
DOI : 10.1016/S0022-1759(02)00195-3

I. Alvarez, M. Martí, J. Vázquez, E. Camafeita, S. Ogueta et al., The Cys-67 Residue of HLA-B27 Influences Cell Surface Stability, Peptide Specificity, and T-cell Antigen Presentation, Journal of Biological Chemistry, vol.276, issue.52, pp.48740-48747, 2001.
DOI : 10.1074/jbc.M108882200

M. Apel, S. Uebe, J. Bowes, E. Giardina, E. Korendowych et al., Variants in RUNX3 contribute to susceptibility to psoriatic arthritis exhibiting further common ground with ankylosing spondylitis, Arthritis & Rheumatism, 2013.

H. Appel, W. Kuon, M. Kuhne, M. Hülsmeyer, S. Kollnberger et al., The Solvent-Inaccessible Cys67 Residue of HLA-B27 Contributes to T Cell Recognition of HLA-B27/Peptide Complexes, The Journal of Immunology, vol.173, issue.11, pp.6564-6573, 2004.
DOI : 10.4049/jimmunol.173.11.6564

H. Appel, M. Kuhne, S. Spiekermann, H. Ebhardt, Z. Grozdanovic et al., Immunohistologic analysis of zygapophyseal joints in patients with ankylosing spondylitis, Arthritis & Rheumatism, vol.60, issue.9, pp.2845-2851, 2006.
DOI : 10.1002/art.22060

R. Benjamin and P. Parham, Guilt by association: HLA-B27 and ankylosing spondylitis, Immunology Today, vol.11, pp.137-142, 1990.
DOI : 10.1016/0167-5699(90)90051-A

F. Bettosini, M. T. Fiorillo, A. Magnacca, L. Leone, M. R. Torrisi et al., The C Terminus of the Nucleoprotein of Influenza A Virus Delivers Antigens Transduced by Tat to the trans-Golgi Network and Promotes an Efficient Presentation through HLA Class I, Journal of Virology, vol.79, issue.24, pp.15537-15546, 2005.
DOI : 10.1128/JVI.79.24.15537-15546.2005

A. C. Boon, G. De-mutsert, R. A. Fouchier, K. Sintnicolaas, A. D. Osterhaus et al., Preferential HLA Usage in the Influenza Virus-Specific CTL Response, The Journal of Immunology, vol.172, issue.7, pp.4435-4443, 2004.
DOI : 10.4049/jimmunol.172.7.4435

D. A. Brewerton, F. D. Hart, A. Nicholls, M. Caffrey, D. C. James et al., ANKYLOSING SPONDYLITIS AND HL-A 27, The Lancet, vol.301, issue.7809, pp.904-907, 1973.
DOI : 10.1016/S0140-6736(73)91360-3

J. M. Brooks, R. J. Murray, W. A. Thomas, M. G. Kurilla, and A. B. Rickinson, Different HLA-B27 subtypes present the same immunodominant Epstein-Barr virus peptide, Journal of Experimental Medicine, vol.178, issue.3, pp.879-887, 1993.
DOI : 10.1084/jem.178.3.879

I. Cascino, F. Paladini, F. Belfiore, A. Cauli, C. Angelini et al., Identification of previously unrecognized predisposing factors for ankylosing spondylitis from analysis of HLA???B27 extended haplotypes in sardinia, Arthritis & Rheumatism, vol.2, issue.8, pp.2640-2651, 2007.
DOI : 10.1002/art.22820

H. Chen, Z. M. Ndhlovu, D. Liu, L. C. Porter, J. W. Fang et al., TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection, Nature Immunology, vol.172, issue.7, pp.691-700, 2012.
DOI : 10.1038/ni.2342

P. Costello, B. Bresnihan, C. O-'farrelly, and O. Fitzgerald, Predominance of CD8+ T lymphocytes in psoriatic arthritis, Journal of Rheumatology, vol.26, pp.1117-1124, 1999.

D. Amato, M. Fiorillo, M. T. Carcassi, C. Mathieu, A. Zuccarelli et al., Relevance of residue 116 of HLA-B27 in determining susceptibility to ankylosing spondylitis, European Journal of Immunology, vol.41, issue.11, pp.3199-3201, 1995.
DOI : 10.1002/eji.1830251133

R. Díaz-peñape?peña, A. López-vázquez, and C. López-larrea, Old and new HLA associations with ankylosing spondylitis, Tissue Antigens, vol.170, issue.Suppl 10, pp.205-213, 2012.
DOI : 10.1111/j.1399-0039.2012.01944.x

S. Elahi, W. L. Dinges, N. Lejarcegui, K. J. Laing, A. C. Collier et al., Protective HIV-specific CD8+ T cells evade Treg cell suppression, Nature Medicine, vol.173, issue.8, pp.989-995, 2011.
DOI : 10.1016/j.jim.2007.03.002

D. M. Evans, C. C. Spencer, J. J. Pointon, Z. Su, D. Harvey et al., Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility, Nature Genetics, vol.3, issue.8, pp.761-767, 2011.
DOI : 10.1093/bioinformatics/btn224

H. Fabian, H. Huser, D. Narzi, R. Misselwitz, B. Loll et al., HLA-B27 Subtypes Differentially Associated with Disease Exhibit Conformational Differences in Solution, Journal of Molecular Biology, vol.376, issue.3, pp.798-810, 2008.
DOI : 10.1016/j.jmb.2007.12.009

H. Fabian, H. Huser, B. Loll, A. Ziegler, D. Naumann et al., HLA-B27 heavy chains distinguished by a micropolymorphism exhibit differential flexibility, Arthritis & Rheumatism, vol.30, issue.4, pp.978-987, 2010.
DOI : 10.1002/art.27316

M. T. Fiorillo, L. Meadows, M. Amato, J. Shabanowitz, D. E. Hunt et al., Susceptibility to ankylosing spondylitis correlates with the C-terminal residue of peptides presented by various HLA-B27 subtypes, European Journal of Immunology, vol.367, issue.2, pp.368-373, 1997.
DOI : 10.1002/eji.1830270205

M. T. Fiorillo, A. Cauli, C. Carcassi, P. P. Bitti, A. Vacca et al., Two distinctive HLA haplotypes harbor the B27 alleles negatively or positively associated with ankylosing spondylitis in Sardinia: Implications for disease pathogenesis, Arthritis & Rheumatism, vol.61, issue.5, pp.1385-1389, 2003.
DOI : 10.1002/art.10948

M. T. Fiorillo and R. Sorrentino, T-Cell Responses Against Viral and Self-Epitopes and HLA-B27 Subtypes Differentially Associated with Ankylosing Spondylitis, Advances in Experimental Medicine and Biology, vol.649, pp.255-262, 2009.
DOI : 10.1007/978-1-4419-0298-6_19

R. J. Franç-ois, L. Neure, J. Sieper, and J. Braun, Immunohistological examination of open sacroiliac biopsies of patients with ankylosing spondylitis: detection of tumour necrosis factor ?? in two patients with early disease and transforming growth factor ?? in three more advanced cases, Annals of the Rheumatic Diseases, vol.65, issue.6, pp.713-720, 2006.
DOI : 10.1136/ard.2005.037465

R. E. Hammer, S. D. Maika, J. A. Richardson, J. P. Tang, and J. D. Taurog, Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human ??2m: An animal model of HLA-B27-associated human disorders, Cell, vol.63, issue.5, pp.1099-1112, 1990.
DOI : 10.1016/0092-8674(90)90512-D

A. Harari, C. Cellerai, F. B. Enders, J. Köstler, L. Codarri et al., Skewed association of polyfunctional antigen-specific CD8 T cell populations with HLA-B genotype, Proceedings of the National Academy of Sciences of the United States of America, pp.16233-16238, 2007.
DOI : 10.1073/pnas.0707570104

S. Infantes, E. Lorente, E. Barnea, I. Beer, A. Barriga et al., Natural HLA-B*2705 Protein Ligands with Glutamine as Anchor Motif: IMPLICATIONS FOR HLA-B27 ASSOCIATION WITH SPONDYLOARTHROPATHY, Journal of Biological Chemistry, vol.288, issue.15, pp.10882-10889, 2013.
DOI : 10.1074/jbc.M113.455352

Y. Kirino, G. Bertsias, Y. Ishigatsubo, N. Mizuki, I. Tugal-tutkun et al., Genome-wide association analysis identifies new susceptibility loci for Beh??et's disease and epistasis between HLA-B*51 and ERAP1, Nature Genetics, vol.335, issue.2, pp.202-207, 2013.
DOI : 10.1101/gr.107672.110

R. M. Leonhardt, D. Fiegl, E. Rufer, A. Karger, B. Bettin et al., Post-Endoplasmic Reticulum Rescue of Unstable MHC Class I Requires Proprotein Convertase PC7, The Journal of Immunology, vol.184, issue.6, pp.2985-2998, 2010.
DOI : 10.4049/jimmunol.0900308

D. R. Madden, J. C. Gorga, J. L. Strominger, and D. C. Wiley, The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation, Nature, vol.353, issue.6342, pp.321-325, 1991.
DOI : 10.1038/353321a0

A. Magnacca, I. Persiconi, E. Nurzia, S. Caristi, F. Meloni et al., Characterization of a Proteasome and TAP-independent Presentation of Intracellular Epitopes by HLA-B27 Molecules, Journal of Biological Chemistry, vol.287, issue.36, pp.30358-30367, 2012.
DOI : 10.1074/jbc.M112.384339
URL : https://hal.archives-ouvertes.fr/pasteur-00965699

M. Marcilla and J. A. López-de-castro, Peptides: the cornerstone of HLA-B27 biology and pathogenetic role in spondyloarthritis, Tissue Antigens, vol.8, issue.6, pp.495-506, 2008.
DOI : 10.1002/art.21395

J. P. Mear, K. L. Schreiber, C. Münz, X. Zhu, S. Stevanoví-c et al., Misfolding of HLA-B27 as a result of its B pocket suggests a novel mechanism for its role in susceptibility to spondyloarthropathies, Journal of Immunology, vol.163, pp.6665-6670, 1999.

D. Narzi, C. M. Becker, M. T. Fiorillo, B. Uchanska-ziegler, A. Ziegler et al., Dynamical Characterization of Two Differentially Disease Associated MHC Class I Proteins in Complex with Viral and Self-Peptides, Journal of Molecular Biology, vol.415, issue.2, pp.429-442, 2012.
DOI : 10.1016/j.jmb.2011.11.021

C. Neumann-haefelin, S. Mckiernan, S. Ward, S. Viazov, H. C. Spangenberg et al., Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolution, Hepatology, vol.35, issue.3, pp.563-572, 2006.
DOI : 10.1002/hep.21049

E. Nurzia, D. Narzi, A. Cauli, A. Mathieu, V. Tedeschi et al., Interaction pattern of Arg 62 in the Apocket of differentially disease-associated HLA-B27 subtypes suggests distinct TCR binding modes, PLoS One, vol.7, 2012.
URL : https://hal.archives-ouvertes.fr/pasteur-00966917

S. J. Powis, S. G. Santos, and A. N. Antoniou, Biochemical Features of HLA-B27 and Antigen Processing, Advances in Experimental Medicine and Biology, vol.649, pp.210-216, 2009.
DOI : 10.1007/978-1-4419-0298-6_15

J. D. Reveille and R. M. Maganti, Subtypes of HLA-B27: History and Implications in the Pathogenesis of Ankylosing Spondylitis, Advances in Experimental Medicine and Biology, vol.649, pp.159-176, 2009.
DOI : 10.1007/978-1-4419-0298-6_12

L. Schlosstein, P. I. Terasaki, R. Bluestone, and C. M. Pearson, High Association of an HL-A Antigen, W27, with Ankylosing Spondylitis, New England Journal of Medicine, vol.288, issue.14, pp.704-706, 1973.
DOI : 10.1056/NEJM197304052881403

J. Schmidt, A. K. Iversen, S. Tenzer, E. Gostick, D. A. Price et al., Rapid Antigen Processing and Presentation of a Protective and Immunodominant HLA-B*27-restricted Hepatitis C Virus-specific CD8+ T-cell Epitope, PLoS Pathogens, vol.172, issue.11, 2012.
DOI : 10.1371/journal.ppat.1003042.s003

A. Strange, F. Capon, C. C. Spencer, J. Knight, M. E. Weale et al., A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1, Nature Genetics, vol.447, issue.11, pp.985-990, 2010.
DOI : 10.1086/319501

J. D. Taurog, M. L. Dorris, N. Satumtira, T. M. Tran, R. Sharma et al., Spondylarthritis in HLA-B27/human beta2- microglobulin-transgenic rats is not prevented by lack of CD8, Arthritis & Rheumatism, vol.60, 1977.

S. Tenzer, E. Wee, A. Burgevin, G. Stewart-jones, L. Friis et al., Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance, Nature Immunology, vol.59, issue.6, pp.636-646, 2009.
DOI : 10.1038/ni.1728
URL : https://hal.archives-ouvertes.fr/inserm-00663574

B. Uchanska-ziegler, B. Loll, H. Fabian, C. S. Hee, W. Saenger et al., HLA class I-associated diseases with a suspected autoimmune etiology: HLA-B27 subtypes as a model system, European Journal of Cell Biology, vol.91, issue.4, pp.274-286, 2012.
DOI : 10.1016/j.ejcb.2011.03.003

R. G. Urban, R. M. Chicz, W. S. Lane, J. L. Strominger, A. Rehm et al., A subset of HLA-B27 molecules contains peptides much longer than nonamers., Proceedings of the National Academy of Sciences of the United States of America 91, pp.1534-1538, 1994.
DOI : 10.1073/pnas.91.4.1534

I. Wong-baeza, A. Ridley, J. Shaw, H. Hatano, O. Rysnik et al., KIR3DL2 Binds to HLA-B27 Dimers and Free H Chains More Strongly than Other HLA Class I and Promotes the Expansion of T Cells in Ankylosing Spondylitis, The Journal of Immunology, vol.190, issue.7, pp.3216-3224, 2013.
DOI : 10.4049/jimmunol.1202926