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Journal Articles ACS Medicinal Chemistry Letters Year : 2013

New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi.

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Abstract

The antiparasitic activity of azole and new 4-aminopyridine derivatives has been investigated. The imidazoles 1 and 3-5 showed a potent in vitro antichagasic activity with IC50 values in the low nanomolar concentration range. The (S)-1, (S)-3, and (S)-5 enantiomers showed (up to) a thousand-fold higher activity than the reference drug benznidazole and furthermore low cytotoxicity on rat myogenic L6 cells.
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pasteur-01054197 , version 1 (05-08-2014)

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Laura Friggeri, Luigi Scipione, Roberta Costi, Marcel Kaiser, Francesca Moraca, et al.. New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi.. ACS Medicinal Chemistry Letters, 2013, 4 (6), pp.538-41. ⟨10.1021/ml400039r⟩. ⟨pasteur-01054197⟩

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