New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi.

Abstract : The antiparasitic activity of azole and new 4-aminopyridine derivatives has been investigated. The imidazoles 1 and 3-5 showed a potent in vitro antichagasic activity with IC50 values in the low nanomolar concentration range. The (S)-1, (S)-3, and (S)-5 enantiomers showed (up to) a thousand-fold higher activity than the reference drug benznidazole and furthermore low cytotoxicity on rat myogenic L6 cells.
Complete list of metadatas

Cited literature [8 references]  Display  Hide  Download

https://hal-riip.archives-ouvertes.fr/pasteur-01054197
Contributor : Istituto Pasteur Fondazione Cenci Bolognetti <>
Submitted on : Tuesday, August 5, 2014 - 1:27:47 PM
Last modification on : Wednesday, October 10, 2018 - 3:46:02 PM
Long-term archiving on : Tuesday, April 11, 2017 - 7:00:43 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Laura Friggeri, Luigi Scipione, Roberta Costi, Marcel Kaiser, Francesca Moraca, et al.. New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi.. ACS Medicinal Chemistry Letters, American Chemical Society, 2013, 4 (6), pp.538-41. ⟨10.1021/ml400039r⟩. ⟨pasteur-01054197⟩

Share

Metrics

Record views

177