New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi. - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles ACS Medicinal Chemistry Letters Year : 2013

New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi.

Abstract

The antiparasitic activity of azole and new 4-aminopyridine derivatives has been investigated. The imidazoles 1 and 3-5 showed a potent in vitro antichagasic activity with IC50 values in the low nanomolar concentration range. The (S)-1, (S)-3, and (S)-5 enantiomers showed (up to) a thousand-fold higher activity than the reference drug benznidazole and furthermore low cytotoxicity on rat myogenic L6 cells.
Embargoed file
Embargoed file
Ne sera jamais visible
Loading...

Dates and versions

pasteur-01054197 , version 1 (05-08-2014)

Identifiers

Cite

Laura Friggeri, Luigi Scipione, Roberta Costi, Marcel Kaiser, Francesca Moraca, et al.. New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi.. ACS Medicinal Chemistry Letters, 2013, 4 (6), pp.538-41. ⟨10.1021/ml400039r⟩. ⟨pasteur-01054197⟩

Collections

RIIP RIIP_FCB
42 View
1 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More