Arylsulfone-based HIV-1 non-nucleoside reverse transcriptase inhibitors.

Abstract : HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) represent one of the most significant classes of drugs for the treatment of AIDS/HIV infection. Over the past two decades several potent arylsulfone-based HIV-1 NNRTIs and related analogs have been developed. This review provides an essential overview of the structure-activity relationships of the arylsulfone-based HIV-1 NNRTIs. Furthermore, structural information useful for the design and development of new sulfur containing NNRTIs with enhanced antiretroviral activity against HIV-1 wild type and clinically relevant drug resistant HIV-1 mutant strains will be discussed.
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https://hal-riip.archives-ouvertes.fr/pasteur-01054201
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Submitted on : Tuesday, August 5, 2014 - 1:42:58 PM
Last modification on : Wednesday, October 10, 2018 - 3:46:02 PM
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Valeria Famiglini, Antonio Coluccia, Andrea Brancale, Sveva Pelliccia, Giuseppe La Regina, et al.. Arylsulfone-based HIV-1 non-nucleoside reverse transcriptase inhibitors.. Future Medicinal Chemistry, Future Science, 2013, 5 (18), pp.2141-56. ⟨10.4155/fmc.13.174⟩. ⟨pasteur-01054201⟩

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