S. F. Altschul, Gapped BLAST and PSI-BLAST: a new generation of protein database search programs, Nucleic Acids Research, vol.25, issue.17, pp.3389-3402, 1997.
DOI : 10.1093/nar/25.17.3389

V. A. Arankalle, Genetic divergence of Chikungunya viruses in India (1963-2006) with special reference to the 2005-2006 explosive epidemic, Journal of General Virology, vol.88, issue.7, pp.1967-1976, 1963.
DOI : 10.1099/vir.0.82714-0

M. Bourjot, Chemical constituents of Anacolosa pervilleana and their antiviral activities, Fitoterapia, vol.83, issue.6, pp.1076-1080, 2012.
DOI : 10.1016/j.fitote.2012.05.004
URL : https://hal.archives-ouvertes.fr/hal-00722062

C. Colovos and T. O. Yeates, Verification of protein structures: Patterns of nonbonded atomic interactions, Protein Science, vol.245, issue.9, pp.1511-1519, 1993.
DOI : 10.1002/pro.5560020916

X. De-lamballerie, On Chikungunya Acute Infection and Chloroquine Treatment, Vector-Borne and Zoonotic Diseases, vol.8, issue.6, pp.837-839, 2008.
DOI : 10.1089/vbz.2008.0049

I. Delogu, In vitro antiviral activity of arbidol against Chikungunya virus and characteristics of a selected resistant mutant, Antiviral Research, vol.90, issue.3, pp.99-107, 2011.
DOI : 10.1016/j.antiviral.2011.03.182

P. Hochedez, Cases of chikungunya fever imported from the islands of the South West Indian Ocean to Paris France, Euro Surveill, vol.12, 2007.

M. Khan, Cellular IMPDH enzyme activity is a potential target for the inhibition of Chikungunya virus replication and virus induced apoptosis in cultured mammalian cells, Antiviral Research, vol.89, issue.1, pp.1-8, 2011.
DOI : 10.1016/j.antiviral.2010.10.009

M. Khan, Assessment of in vitro prophylactic and therapeutic efficacy of chloroquine against chikungunya virus in vero cells, Journal of Medical Virology, vol.2, issue.5, pp.817-824, 2010.
DOI : 10.1002/jmv.21663

O. Korb, Empirical Scoring Functions for Advanced Protein???Ligand Docking with PLANTS, Journal of Chemical Information and Modeling, vol.49, issue.1, pp.84-96, 2009.
DOI : 10.1021/ci800298z

Y. G. Li, Poly (I:C), an agonist of toll-like receptor-3, inhibits replication of the Chikungunya virus in BEAS-2B cells, Virology Journal, vol.9, issue.1, p.114, 2012.
DOI : 10.1371/journal.ppat.1000373

S. C. Lovell, Structure validation by C?? geometry: ??,?? and C?? deviation, Proteins: Structure, Function, and Bioinformatics, vol.320, issue.3, pp.437-450, 2003.
DOI : 10.1002/prot.10286

R. Luthy, Assessment of protein models with three-dimensional profiles, Nature, vol.356, issue.6364, pp.83-85, 1992.
DOI : 10.1038/356083a0

S. Perri, Replicon Vectors Derived from Sindbis Virus and Semliki Forest Virus That Establish Persistent Replication in Host Cells, Journal of Virology, vol.74, issue.20, pp.9802-9807, 2000.
DOI : 10.1128/JVI.74.20.9802-9807.2000

L. Pohjala, Inhibitors of Alphavirus Entry and Replication Identified with a Stable Chikungunya Replicon Cell Line and Virus-Based Assays, PLoS ONE, vol.3, issue.1, 2011.
DOI : 10.1371/journal.pone.0028923.s002

M. Rarey, A Fast Flexible Docking Method using an Incremental Construction Algorithm, Journal of Molecular Biology, vol.261, issue.3, pp.470-489, 1996.
DOI : 10.1006/jmbi.1996.0477

R. W. Ross, The Newala epidemic: III. The virus: isolation, pathogenic properties and relationship to the epidemic, Journal of Hygiene, vol.1, issue.02, pp.177-191, 1956.
DOI : 10.1016/0035-9203(55)90080-8

A. T. Russo, Structural basis for substrate specificity of alphavirus nsP2 proteases, Journal of Molecular Graphics and Modelling, vol.29, issue.1, pp.46-53, 2010.
DOI : 10.1016/j.jmgm.2010.04.005

A. T. Russo, The Crystal Structure of the Venezuelan Equine Encephalitis Alphavirus nsP2 Protease, Structure, vol.14, issue.9, pp.1449-1458, 2006.
DOI : 10.1016/j.str.2006.07.010

K. H. Singh, Homology modeling, molecular dynamics, e-pharmacophore mapping and docking study of Chikungunya virus nsP2 protease, Journal of Molecular Modeling, vol.23, issue.1, pp.39-51, 2012.
DOI : 10.1007/s00894-011-1018-3

D. Sissoko, Post-Epidemic Chikungunya Disease on Reunion Island: Course of Rheumatic Manifestations and Associated Factors over a 15-Month Period, PLoS Neglected Tropical Diseases, vol.86, issue.3, p.389, 2009.
DOI : 10.1371/journal.pntd.0000389.s001

M. Solignat, Replication cycle of chikungunya: A re-emerging arbovirus, Virology, vol.393, issue.2, pp.183-197, 2009.
DOI : 10.1016/j.virol.2009.07.024
URL : https://hal.archives-ouvertes.fr/hal-00420502

M. Sourisseau, Characterization of Reemerging Chikungunya Virus, PLoS Pathogens, vol.4, issue.6, p.89, 2007.
DOI : 0889-2229(1988)004[0441:ARASTF]2.0.CO;2
URL : https://hal.archives-ouvertes.fr/pasteur-00161827

J. H. Strauss and E. G. Strauss, The alphaviruses: gene expression, replication, and evolution, Microbiol. Rev, vol.58, pp.491-562, 1994.

K. A. Tsetsarkin, Epistatic Roles of E2 Glycoprotein Mutations in Adaption of Chikungunya Virus to Aedes Albopictus and Ae. Aegypti Mosquitoes, PLoS ONE, vol.9, issue.8, p.6835, 2009.
DOI : 10.1371/journal.pone.0006835.s003

D. L. Vanlandingham, Differential infectivities of o'nyong-nyong and chikungunya virus isolates in anopheles gambiae and Aedes aegypti mosquitoes, Am. J. Trop. Med. Hyg, vol.72, pp.616-621, 2005.

R. Wang and S. Wang, How Does Consensus Scoring Work for Virtual Library Screening? An Idealized Computer Experiment, Journal of Chemical Information and Computer Sciences, vol.41, issue.5, pp.1422-1426, 2001.
DOI : 10.1021/ci010025x