 |
Journal articles
Efficacy of eosin B as a new antimalarial drug in a murine model.
Abstract : The initial success of any adopted anti-infective strategy to malaria is followed by a descent due to the emergence of resistance to it. The search for new drugs and drug targets is a consistent demand in this disease. Eosin B, a common laboratory dye, is reported to have good antiparasitic properties in vitro. It was studied for its antiparasitic effect in vivo on chloroquine-sensitive Plasmodium berghei murine malaria. Eosin B was administered in 2 different doses by either the oral or parenteral route, once or twice daily to mice infected with Plasmodium berghei. Both the doses of eosin B 400 mg/kg and 800 mg/kg gave better results than the controls which were 40 mg/kg chloroquine and 100 mg/kg of arteether with P < 0.005 significance. Percentage suppressive activity by Peter's test of eosin B was better, though at a higher dose than both the controls. Survival rate of mice receiving the higher dose of eosin B was longer than that of the controls. When administered twice daily, the mice were fully cured after 4 days. Eosin B seems to be a promising drug exhibiting good antimalarial effects in the murine model of the disease.
https://hal-riip.archives-ouvertes.fr/pasteur-01057594
Contributor : Zahra Zamani Connect in order to contact the contributor
Submitted on : Sunday, August 24, 2014 - 3:06:37 PM
Last modification on : Wednesday, October 14, 2020 - 3:49:21 AM
Contributor : Zahra Zamani Connect in order to contact the contributor
Submitted on : Sunday, August 24, 2014 - 3:06:37 PM
Last modification on : Wednesday, October 14, 2020 - 3:49:21 AM
Files
381724.pdf
Publisher files allowed on an open archive
- eosin_b.pdf Embargoed until : jamais Files produced by the author(s)