Evidence for Association of the E23K Variant of KCNJ11 Gene with Type 2 Diabetes in Tunisian Population: Population-Based Study and Meta-Analysis.

Khaled Lasram (1, 2) , Nizar Ben Halim (1, 2) , Sana Hsouna (1, 2) , Rym Kefi (1, 2) , Imen Arfa (1, 2) , Welid Ghazouani (1, 2) , Henda Jamoussi (1, 3) , Houda Benrahma (4) , Najla Kharrat (5) , Ahmed-Riadh Rebai (5) , Slim Ben Ammar (2, 6) , Sonia Bahri (6, 2) , Abdelhamid Barakat (4) , Abdelmajid Abid (1, 2) , Sonia Abdelhak (1, 2)

1 LR11IPT05 - Laboratoire de Génomique Biomédicale et Oncogénétique - Biomedical Genomics and Oncogenetics Laboratory
2 UTM - Université de Tunis El Manar
3 National Institute of Nutrition and Food Technology, Department of External Consultation, 11 rue Jebel Lakhdar, Bab Saadoun, 1007 Tunis, Tunisia.
4 Institut Pasteur du Maroc
5 CBS - Centre de Biotechnologie de Sfax
6 Laboratoire central de biologie médicale, Institut Pasteur de Tunis

Aims. Genetic association studies have reported the E23K variant of KCNJ11 gene to be associated with Type 2 diabetes. In Arab populations, only four studies have investigated the role of this variant. We aimed to replicate and validate the association between the E23K variant and Type 2 diabetes in Tunisian and Arab populations. Methods. We have performed a case-control association study including 250 Tunisian patients with Type 2 diabetes and 267 controls. Allelic association has also been evaluated by 2 meta-analyses including all population-based studies among Tunisians and Arabs (2 and 5 populations, resp.). Results. A significant association between the E23K variant and Type 2 diabetes was found (OR = 1.6, 95% CI = 1.14-2.27, and P = 0.007). Furthermore, our meta-analysis has confirmed the significant role of the E23K variant in susceptibility of Type 2 diabetes in Tunisian and Arab populations (OR = 1.29, 95% CI = 1.15-1.46, and P < 10(-3) and OR = 1.33, 95% CI = 1.13-1.56, and P = 0.001, resp.). Conclusion. Both case-control and meta-analyses results revealed the significant association between the E23K variant of KCNJ11 and Type 2 diabetes among Tunisians and Arabs.

Domaines: Sciences du Vivant [q-bio]

Khaled Lasram, Nizar Ben Halim, Sana Hsouna, Rym Kefi, Imen Arfa, et al.. Evidence for Association of the E23K Variant of KCNJ11 Gene with Type 2 Diabetes in Tunisian Population: Population-Based Study and Meta-Analysis.. BioMed Research International , 2014, 2014, pp.265274. ⟨10.1155/2014/265274⟩. ⟨pasteur-01059829⟩